Navigation Links
Anti Inflammatory Evaluation Of Plumeria Acuminata Leaves

Department of Pharmaceutical Technology, Jadavpur University, Kolkata and Department of Pharmaceutical Chemistry, ASN Pharmacy College, Andhra Pradesh done a// study on Plumeria Acuminata leaves. The objective of the present study was to evaluate the anti-inflammatory activity of methanol extract of leaves of Plumeria Acuminata on carrageenan, dextran, histamine and serotonin-induced inflammation in rat hind paw oedema models.

Plumeria Acuminata belongs to the family of Apocynaceae, which is commonly known as 'perungalli' in Tamil and is widely distributed throughout the Southern parts of India. In traditional medicinal system different parts of the plant have been mentioned to be useful in a variety of diseases. The plant material is widely used as a purgative, remedy for diarrhoea and cure for itch. The milky juice is employed for the treatment of inflammation and rheumatism. The bark has been reported to be useful in hard tumors, diarrhoea and gonorrhoea.

Methods

Acute and chronic inflammation models were used to evaluate the anti-inflammatory activity of the extract. Wistar albino rats of either sex weighing 180a€“200 g were used. In acute model carrageenan, dextran, histamine and serotonin models were used to induce inflammation in rat hind paw and cotton pellet-induced granuloma method was used for chronic inflammation model. In each model four groups of six animals were used. In all the models Group I served as control (0.9% normal saline, 5 mlkg-1 b.w) and group IV as standard (Indomethacin 10 mgkg-1 b.w). Group II and III received extract at the doses of 250 and 500 mgkg-1 b.w respectively.

Results

The methanol extract of Plumeria acuminata exhibited significant anti-inflammatory activity on the tested experimental animal models. The extract (500 mgkg-1 b.w) exhibited maximum anti-inflammatory effect i.e., 30.51, 47.06, 34.48 and 32.50% (P< 0.001) at the end of 3 h with carrageenan, dextra n, histamine and serotonin respectively. Administration of MEPA (500 mgkg-1 b.w) and indomethacin (10 mgkg-1 b.w) significantly reduced the formation of granuloma tissue induced by cotton pellet method at a rate of 45.06 and 51.57% respectively. The effect produced by the extract was comparable to that of indomethacin a prototype of a nonsteroidal anti-inflammatory agent.

Conclusion

The results obtained in this study indicated that the methanol extract of Plumeria Acuminata possess potent anti-inflammatory activity in both acute and chronic models.
SRI
'"/>




Related medicine news :

1. The Usage Of Anti-Inflammatory Drugs Questioned
2. Hope For Patients With Inflammatory Bowel Disease
3. FDA to bring about changes in Marketed Non-Steroidal Anti-Inflammatory Drugs
4. Inflammatory bowel disease linked to genetic abnormality
5. Elevated Insulin Levels To Influence Levels Of Inflammatory Markers
6. Cannabinoids - Antidepressant And Inflammatory Bowel Disease Treatment
7. Ambiguous Efficacy Of Opioid Drugs In Chronic Inflammatory Joint Pain Relief
8. A Component In Milk May Help Control Inflammatory Diseases
9. Five New Anti-Inflammatory Compounds Produced By Indian Scientists
10. Australian Scientists Develop Novel Drug To Combat Inflammatory Diseases
11. Inflammatory Bowel Diseases Cured By Parasitic Worms
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: