Navigation Links
Anti Inflammatory Evaluation Of Plumeria Acuminata Leaves

Department of Pharmaceutical Technology, Jadavpur University, Kolkata and Department of Pharmaceutical Chemistry, ASN Pharmacy College, Andhra Pradesh done a// study on Plumeria Acuminata leaves. The objective of the present study was to evaluate the anti-inflammatory activity of methanol extract of leaves of Plumeria Acuminata on carrageenan, dextran, histamine and serotonin-induced inflammation in rat hind paw oedema models.

Plumeria Acuminata belongs to the family of Apocynaceae, which is commonly known as 'perungalli' in Tamil and is widely distributed throughout the Southern parts of India. In traditional medicinal system different parts of the plant have been mentioned to be useful in a variety of diseases. The plant material is widely used as a purgative, remedy for diarrhoea and cure for itch. The milky juice is employed for the treatment of inflammation and rheumatism. The bark has been reported to be useful in hard tumors, diarrhoea and gonorrhoea.

Methods

Acute and chronic inflammation models were used to evaluate the anti-inflammatory activity of the extract. Wistar albino rats of either sex weighing 180a€“200 g were used. In acute model carrageenan, dextran, histamine and serotonin models were used to induce inflammation in rat hind paw and cotton pellet-induced granuloma method was used for chronic inflammation model. In each model four groups of six animals were used. In all the models Group I served as control (0.9% normal saline, 5 mlkg-1 b.w) and group IV as standard (Indomethacin 10 mgkg-1 b.w). Group II and III received extract at the doses of 250 and 500 mgkg-1 b.w respectively.

Results

The methanol extract of Plumeria acuminata exhibited significant anti-inflammatory activity on the tested experimental animal models. The extract (500 mgkg-1 b.w) exhibited maximum anti-inflammatory effect i.e., 30.51, 47.06, 34.48 and 32.50% (P< 0.001) at the end of 3 h with carrageenan, dextra n, histamine and serotonin respectively. Administration of MEPA (500 mgkg-1 b.w) and indomethacin (10 mgkg-1 b.w) significantly reduced the formation of granuloma tissue induced by cotton pellet method at a rate of 45.06 and 51.57% respectively. The effect produced by the extract was comparable to that of indomethacin a prototype of a nonsteroidal anti-inflammatory agent.

Conclusion

The results obtained in this study indicated that the methanol extract of Plumeria Acuminata possess potent anti-inflammatory activity in both acute and chronic models.
SRI
'"/>




Related medicine news :

1. The Usage Of Anti-Inflammatory Drugs Questioned
2. Hope For Patients With Inflammatory Bowel Disease
3. FDA to bring about changes in Marketed Non-Steroidal Anti-Inflammatory Drugs
4. Inflammatory bowel disease linked to genetic abnormality
5. Elevated Insulin Levels To Influence Levels Of Inflammatory Markers
6. Cannabinoids - Antidepressant And Inflammatory Bowel Disease Treatment
7. Ambiguous Efficacy Of Opioid Drugs In Chronic Inflammatory Joint Pain Relief
8. A Component In Milk May Help Control Inflammatory Diseases
9. Five New Anti-Inflammatory Compounds Produced By Indian Scientists
10. Australian Scientists Develop Novel Drug To Combat Inflammatory Diseases
11. Inflammatory Bowel Diseases Cured By Parasitic Worms
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... ... September 20, 2017 , ... Demand generation pioneer ... East-coast edition of MarTech: The Marketing Tech Conference October 2–4, at the Hynes ... 40 speakers — representing such thought-leading companies as JP Morgan Chase, GE ...
(Date:9/20/2017)... ... September 20, 2017 , ... Compliancy ... industry-leading compliance software, The Guard®, has helped another long-time client pass their Department ... and properly satisfy the law. , Thanks to the help of the Compliancy ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... campaign, “Humans With Vaginas.” The goal is to ignite conversation via social media ... care products. The brand has declared September “Humans with Vaginas” month, releasing a ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... millions of older Americans at risk of price gouging for their prescription drugs, ... League (TSCL) . “Because Medicare isn’t negotiating on our behalf, there’s no consistency ...
(Date:9/20/2017)... ... ... “The Trials I Face to Receive God’s Grace”: a mesmerizing take on one ... better one’s life through God. “The Trials I Face to Receive God’s Grace” is ... found a love for writing. Green feels that expressing his feelings through prayer will ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... clinical grade cell and tissue hypothermic storage and ... Rice , President and CEO, will be presenting at two ... & Renshaw 19 th Annual Global Investment Conference on ... Pacific time). The conference is being held at the New ...
(Date:9/6/2017)... , Sept. 6, 2017  Medical professionals ... and skills while treating their patients. Medical ... experience without involving patients. Simulation provides a ... can carry out procedures, refine techniques and ... Integration of new technology, such as augmented ...
(Date:9/6/2017)... -- NeuroRx, a clinical stage biopharma company developing the first ... been granted Fast Track status by the US Food and ... followed by NRX-101 (D-cycloserine + lurasidone). The company will shortly ... therapy targeting patients who are admitted to Emergency Departments with ... ...
Breaking Medicine Technology: