Navigation Links
Anti-Epileptic Drug Intake May Result In Children With Mental Retardation

According to American scientists, women who took an epilepsy drug during their pregnancy are at greater risk of having children with lower IQ.

In question is the drug valproate (already at the center of a British court action after claims that it has damaged children). Valproate seems to double the chance that the woman's child will be born with mental retardation.

Around 140 British families claim that their children are suffering from fetal anti-convulsant syndrome because their mothers took valproate during pregnancy. The syndrome includes a range of neural, behavioral and physical disorders such as cleft palate and spina bifida, learning difficulties, behavioral problems and abnormalities in movement, speech, vision and hearing.

Many mothers were prescribed the brand Epilim, made by Sanofi-Synthelabo, though the drug is also available in generic forms. As of now, Sanofi is the only company involved in the court action, with a trial date set for October 2008.

Lead researcher Kimford Meador, of the University of Florida in Gainesville, looked at IQ results of 187 children born to mothers who had taken the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate during pregnancy.

The results, presented yesterday at the American Academy of Neurology's annual meeting in Boston, showed that 24 percent of the children of mothers who took valproate had an IQ low enough to be defined as mentally retarded. This was against 12 percent for carbamazepine, 9 percent for lamotrigine, and 12 percent for phenytoin.

The results are published in the journal Neurology.

Children whose mothers took carbamazepine scored an average of 93 points on the IQ tests, those on phenytoin 93, lamotrigine 96, and 84 for valproate.

Says Meador: "Our findings are consistent with other studies, which have shown valproate poses an increased risk for fetal death and birth defect.

Yet, Ingrid Burn s of the British Epilepsy Association adopts a middle path: "We believe there should be a balance struck between the potential effects of seizures on the developing brain of fetuses and the effects of valproate. While this is very concerning, it has to be said that valproate is a highly effective anti-epileptic drug."

Meador urges doctors to talk to their patients about the risks associated with valproate. "Valproate should not be used as the drug of first choice for women of child bearing potential, and when used, its dosage should be limited if possible."

Ms Burns agrees that women with epilepsy should be counseled before embarking on a pregnancy: "What we don't want is to scare people to stop people taking this drug suddenly because that can result in seizures and, potentially, deaths."

A Sanofi-Synthelabo spokeswoman was quoted: " The appropriate treatment of epilepsy during pregnancy is a highly complex area and Sanofi-Synthelabo . would urge patients not to make sudden changes to their medication without first discussing them with their doctor."


'"/>




Related medicine news :

1. Anti-Epileptic Drug Intake May Result In Children With Mental Retardation
2. Dangers of Low Calcium Intake
3. Caffeine Intake May reduce Insulin Sensitivity
4. Robo-Dog To Monitor Your Calorie Intake
5. Intake Of Processed Meat And Fat Associated With Pancreatic Cancer
6. Excess Intake of Alcohol Results in Permanent DNA Damage.
7. Intake of a healthy and balanced diet: miracle for old people.
8. Newborns Affected By Antidepressant Intake Of Mothers
9. Salt & Its Intake Causes a Strong debate In UK
10. Pre-eclampsia Pronounced With Intake of Vitamins in Large Doses
11. Viewing TV During Lunch Affects Childrens Food Intake
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... ... autologous fat (adipose) transfer systems announces the issuance of United States Patent Number ... for its adipose filtration technology. The '398 and '324 patents cover methods ...
(Date:7/24/2017)... Georgia (PRWEB) , ... July 24, 2017 , ... ... comprehensive sleep management solution focused on delivering end-to-end sleep health care ... program. , Recent literature shows that adherence rates for positive airway pressure (PAP) ...
(Date:7/24/2017)... ... July 24, 2017 , ... Committed to ... have enrolled over 100,000 children in their treatment program. Clubfoot is a pervasive ... areas where treatment is limited or non-existent. Without intervention, these children are destined ...
(Date:7/24/2017)... Shandong Province (PRWEB) , ... July 24, 2017 ... ... Chinese Medicine's "Chinese Medicine Clinical Vitiligo Hospital" was set up, and the awarding ... Administration of traditional Chinese medicine, the head of the army's health system, and ...
(Date:7/24/2017)... ... 24, 2017 , ... “A Short Walk to the Mailbox”: a remarkable memoir ... of published author, Ed Clark. Ed Clark is a church music director and ... a minister of music and worship leader for over fifty years. He has ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ... the development of oral drug delivery systems, announced today ... agreed to schedule an End-of-Phase II meeting with Oramed ... oral insulin capsule ORMD-0801 in the treatment of type ... secondary endpoints by indicating a statistically significant lowering of ...
(Date:7/10/2017)... , July 10, 2017  BDI Group ... and patient support services organization serving specialty pharmacies, ... the launch of four significant, value-added member programs ... insights, better manage reimbursement and improve access and ... factor therapies. ...
(Date:7/6/2017)... ThriveRx, the nutrition division of Diplomat Specialty Infusion Group, is celebrating a ... To celebrate its anniversary, ThriveRx recently launched a redesigned website ... with improved organization to create the best user experience for consumers and ... ... "We,ve made several great strides throughout the ...
Breaking Medicine Technology: