Navigation Links
Anti-Epileptic Drug Intake May Result In Children With Mental Retardation

According to American scientists, women who took an epilepsy drug during their pregnancy are at greater risk of having children with lower IQ.

In question is the drug valproate (already at the center of a British court action after claims that it has damaged children). Valproate seems to double the chance that the woman's child will be born with mental retardation.

Around 140 British families claim that their children are suffering from fetal anti-convulsant syndrome because their mothers took valproate during pregnancy. The syndrome includes a range of neural, behavioral and physical disorders such as cleft palate and spina bifida, learning difficulties, behavioral problems and abnormalities in movement, speech, vision and hearing.

Many mothers were prescribed the brand Epilim, made by Sanofi-Synthelabo, though the drug is also available in generic forms. As of now, Sanofi is the only company involved in the court action, with a trial date set for October 2008.

Lead researcher Kimford Meador, of the University of Florida in Gainesville, looked at IQ results of 187 children born to mothers who had taken the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate during pregnancy.

The results, presented yesterday at the American Academy of Neurology's annual meeting in Boston, showed that 24 percent of the children of mothers who took valproate had an IQ low enough to be defined as mentally retarded. This was against 12 percent for carbamazepine, 9 percent for lamotrigine, and 12 percent for phenytoin.

The results are published in the journal Neurology.

Children whose mothers took carbamazepine scored an average of 93 points on the IQ tests, those on phenytoin 93, lamotrigine 96, and 84 for valproate.

Says Meador: "Our findings are consistent with other studies, which have shown valproate poses an increased risk for fetal death and birth defect.

Yet, Ingrid Burn s of the British Epilepsy Association adopts a middle path: "We believe there should be a balance struck between the potential effects of seizures on the developing brain of fetuses and the effects of valproate. While this is very concerning, it has to be said that valproate is a highly effective anti-epileptic drug."

Meador urges doctors to talk to their patients about the risks associated with valproate. "Valproate should not be used as the drug of first choice for women of child bearing potential, and when used, its dosage should be limited if possible."

Ms Burns agrees that women with epilepsy should be counseled before embarking on a pregnancy: "What we don't want is to scare people to stop people taking this drug suddenly because that can result in seizures and, potentially, deaths."

A Sanofi-Synthelabo spokeswoman was quoted: " The appropriate treatment of epilepsy during pregnancy is a highly complex area and Sanofi-Synthelabo . would urge patients not to make sudden changes to their medication without first discussing them with their doctor."


'"/>




Related medicine news :

1. Anti-Epileptic Drug Intake May Result In Children With Mental Retardation
2. Dangers of Low Calcium Intake
3. Caffeine Intake May reduce Insulin Sensitivity
4. Robo-Dog To Monitor Your Calorie Intake
5. Intake Of Processed Meat And Fat Associated With Pancreatic Cancer
6. Excess Intake of Alcohol Results in Permanent DNA Damage.
7. Intake of a healthy and balanced diet: miracle for old people.
8. Newborns Affected By Antidepressant Intake Of Mothers
9. Salt & Its Intake Causes a Strong debate In UK
10. Pre-eclampsia Pronounced With Intake of Vitamins in Large Doses
11. Viewing TV During Lunch Affects Childrens Food Intake
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... Silver Spring, MD (PRWEB) , ... January 18, 2017 , ... ... and financial consultations to families and business owners in central Maryland and the DC ... community. , Heart disease kills 787,000 people nationally every year, making it the #1 ...
(Date:1/18/2017)... N.J. (PRWEB) , ... January 18, 2017 , ... ... delivery technologies and development solutions for drugs, biologics and consumer health products, today ... will be presenting at the upcoming WCBP Conference, to be held at the ...
(Date:1/18/2017)... Hills, CA (PRWEB) , ... January 18, 2017 ... ... of dental problems ranging from gum disease to enamel erosion, and those dental ... the Massachusetts Department of Public Health, many pregnant women are failing to get ...
(Date:1/17/2017)... ... January 17, 2017 , ... Gym Source, America’s leading retailer of ... at South Dixie Hwy in Miami, FL. , “We are elated to be opening ... innovative in-store concept is designed to give clients a seamless and motivating shopping experience.” ...
(Date:1/17/2017)... Phoenix, AZ (PRWEB) , ... January 17, 2017 ... ... new and improved supplement, Healthful-Flex. , The company, owned and operated by ... the public at a reasonable price with the highest level of customer service. ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... After the recent election cycle, it is clear ... for medical and recreational purposes are shifting. The evidence shows ... of cannabis, but the focus is coming from both the ... North American legal cannabis market posted $6.7 billion in revenue ... projects sales will grow at a compound annual growth rate ...
(Date:1/17/2017)... , Jan. 17, 2017 Precision medicine ... for the treatment of disease. The approach allows ... to a therapy. The approach studies the individual ... lifestyle and environment. In January 2015, Precision Medicine ... to all diseases with more than one million ...
(Date:1/17/2017)... , Jan. 17, 2017 EU5 Glucose Monitoring ... new report, "EU5 Glucose Monitoring Market Outlook to 2022", ... market. The report provides value, in millions of US ... market segments - Blood Glucose Meters, Blood Glucose Test ... shares and distribution shares data for each of these ...
Breaking Medicine Technology: