Navigation Links
Anti-Epileptic Drug Intake May Result In Children With Mental Retardation

According to American scientists, women who took an epilepsy drug during their pregnancy are at greater risk of having children// with lower IQ.

In question is the drug valproate (already at the center of a British court action after claims that it has damaged children). Valproate seems to double the chance that the woman's child will be born with mental retardation.

Around 140 British families claim that their children are suffering from fetal anti-convulsant syndrome because their mothers took valproate during pregnancy. The syndrome includes a range of neural, behavioral and physical disorders such as cleft palate and spina bifida, learning difficulties, behavioral problems and abnormalities in movement, speech, vision and hearing.

Many mothers were prescribed the brand Epilim, made by Sanofi-Synthelabo, though the drug is also available in generic forms. As of now, Sanofi is the only company involved in the court action, with a trial date set for October 2008.

Lead researcher Kimford Meador, of the University of Florida in Gainesville, looked at IQ results of 187 children born to mothers who had taken the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate during pregnancy.

The results, presented yesterday at the American Academy of Neurology's annual meeting in Boston, showed that 24 percent of the children of mothers who took valproate had an IQ low enough to be defined as mentally retarded. This was against 12 percent for carbamazepine, 9 percent for lamotrigine, and 12 percent for phenytoin.

The results are published in the journal Neurology.

Children whose mothers took carbamazepine scored an average of 93 points on the IQ tests, those on phenytoin 93, lamotrigine 96, and 84 for valproate.

Says Meador: "Our findings are consistent with other studies, which have shown valproate poses an increased risk for fetal death and birth defect.”

Yet, Ingrid Burns of the British Epilepsy Association adopts a middle path: "We believe there should be a balance struck between the potential effects of seizures on the developing brain of fetuses and the effects of valproate. While this is very concerning, it has to be said that valproate is a highly effective anti-epileptic drug."

Meador urges doctors to talk to their patients about the risks associated with valproate. "Valproate should not be used as the drug of first choice for women of child bearing potential, and when used, its dosage should be limited if possible."

Ms Burns agrees that women with epilepsy should be counseled before embarking on a pregnancy: "What we don't want is to scare people to stop people taking this drug suddenly because that can result in seizures and, potentially, deaths."

A Sanofi-Synthelabo spokeswoman was quoted: " The appropriate treatment of epilepsy during pregnancy is a highly complex area and Sanofi-Synthelabo . would urge patients not to make sudden changes to their medication without first discussing them with their doctor."
ANN/B
'"/>




Related medicine news :

1. Dangers of Low Calcium Intake
2. Caffeine Intake May reduce Insulin Sensitivity
3. Robo-Dog To Monitor Your Calorie Intake
4. Intake Of Processed Meat And Fat Associated With Pancreatic Cancer
5. Excess Intake of Alcohol Results in Permanent DNA Damage.
6. Intake of a healthy and balanced diet: miracle for old people.
7. Newborns Affected By Antidepressant Intake Of Mothers
8. Salt & Its Intake Causes a Strong debate In UK
9. Pre-eclampsia Pronounced With Intake of Vitamins in Large Doses
10. Viewing TV During Lunch Affects Childrens Food Intake
11. TV Viewing Increases Intake of Junk Food
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health ... technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing ... form that can be easily incorporated into liquid products, while reducing costs to end ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
Breaking Medicine Technology: