Navigation Links
Anti-Epileptic Drug Intake May Result In Children With Mental Retardation

According to American scientists, women who took an epilepsy drug during their pregnancy are at greater risk of having children// with lower IQ.

In question is the drug valproate (already at the center of a British court action after claims that it has damaged children). Valproate seems to double the chance that the woman's child will be born with mental retardation.

Around 140 British families claim that their children are suffering from fetal anti-convulsant syndrome because their mothers took valproate during pregnancy. The syndrome includes a range of neural, behavioral and physical disorders such as cleft palate and spina bifida, learning difficulties, behavioral problems and abnormalities in movement, speech, vision and hearing.

Many mothers were prescribed the brand Epilim, made by Sanofi-Synthelabo, though the drug is also available in generic forms. As of now, Sanofi is the only company involved in the court action, with a trial date set for October 2008.

Lead researcher Kimford Meador, of the University of Florida in Gainesville, looked at IQ results of 187 children born to mothers who had taken the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate during pregnancy.

The results, presented yesterday at the American Academy of Neurology's annual meeting in Boston, showed that 24 percent of the children of mothers who took valproate had an IQ low enough to be defined as mentally retarded. This was against 12 percent for carbamazepine, 9 percent for lamotrigine, and 12 percent for phenytoin.

The results are published in the journal Neurology.

Children whose mothers took carbamazepine scored an average of 93 points on the IQ tests, those on phenytoin 93, lamotrigine 96, and 84 for valproate.

Says Meador: "Our findings are consistent with other studies, which have shown valproate poses an increased risk for fetal death and birth defect.”

Yet, Ingrid Burns of the British Epilepsy Association adopts a middle path: "We believe there should be a balance struck between the potential effects of seizures on the developing brain of fetuses and the effects of valproate. While this is very concerning, it has to be said that valproate is a highly effective anti-epileptic drug."

Meador urges doctors to talk to their patients about the risks associated with valproate. "Valproate should not be used as the drug of first choice for women of child bearing potential, and when used, its dosage should be limited if possible."

Ms Burns agrees that women with epilepsy should be counseled before embarking on a pregnancy: "What we don't want is to scare people to stop people taking this drug suddenly because that can result in seizures and, potentially, deaths."

A Sanofi-Synthelabo spokeswoman was quoted: " The appropriate treatment of epilepsy during pregnancy is a highly complex area and Sanofi-Synthelabo . would urge patients not to make sudden changes to their medication without first discussing them with their doctor."
ANN/B
'"/>




Related medicine news :

1. Dangers of Low Calcium Intake
2. Caffeine Intake May reduce Insulin Sensitivity
3. Robo-Dog To Monitor Your Calorie Intake
4. Intake Of Processed Meat And Fat Associated With Pancreatic Cancer
5. Excess Intake of Alcohol Results in Permanent DNA Damage.
6. Intake of a healthy and balanced diet: miracle for old people.
7. Newborns Affected By Antidepressant Intake Of Mothers
8. Salt & Its Intake Causes a Strong debate In UK
9. Pre-eclampsia Pronounced With Intake of Vitamins in Large Doses
10. Viewing TV During Lunch Affects Childrens Food Intake
11. TV Viewing Increases Intake of Junk Food
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... Facing medical ... father Ezra Clark is taking advantage of a new benefit for employees that is ... means a lot that the company supports me and other employees as new parents. ...
(Date:7/24/2017)... ... July 24, 2017 , ... ...      (407) 916-7235, kklaproth(at)robinsmorton(dot)com , Robins & Morton, Perkins Will, ... celebrate the structural topping out of the new Destination Medical Building located ...
(Date:7/24/2017)... TX (PRWEB) , ... July 24, 2017 , ... ... under the federal Substance Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted ... of California Department of Health Care Services, will facilitate the development of a ...
(Date:7/24/2017)... ... ... The International Essential Tremor Foundation (IETF) will host a free educational forum in ... take place on Saturday, Aug. 26 at the Embassy Suites by Hilton Cleveland Rockside ... a.m. to 12 p.m., with check-in beginning at 8 a.m. The event is sponsored ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... already work hand-in-hand on an Innovation Collaboration program, have signed a five-year agreement ... and cost of the care members and patients receive. The agreement also signifies ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... GAITHERSBURG, Md. , July 10, 2017 ... in non-animal test methods, is the recipient of a ... by the PETA International Science Consortium. The device, which ... be used to expose human lung cells to airborne ... lung. IIVS will use the VITROCELL® system for testing ...
(Date:7/10/2017)... July 10, 2017 Locus Biosciences Inc. today ... support the development of CRISPR-Cas3 antimicrobial therapeutics. Financing for ... leading Chinese Internet services provider, and joined by the ... infectious disease product programs targeting antibiotic resistant infections and ... Founded by Dr. Rodolphe Barrangou and Dr. ...
(Date:7/5/2017)... , July 5, 2017 ... www.oramed.com ), a clinical-stage pharmaceutical company focused ... that it has received approval from the Israel Securities Authority ... Exchange (TASE). Oramed common stock will commence trading on the ... on the current market capitalization of the Company, it is ...
Breaking Medicine Technology: