Anti cancer drugs have been created from blue green algae by scientists with the knowledge of synthetic chemistry techniques//. Besides this, the information on properties and actions of enzymes is also taken into consideration.
This accomplishment is expected to make it possible to produce enough of the promising drugs for use in clinical trials.
In a study featured on the cover of the January issue of the journal ACS Chemical Biology, a scientific team lead by University of Michigan Life Sciences Institute Research Professor David H. Sherman and researcher Zachary Q. Beck found the trick to turning the green gunk into gold—cancer fighting gold.
"It was simply too difficult to use the native blue-green algae for high-level production using traditional fermentation approaches," said Sherman. But the compound, called cryptophycin 1, held so much promise as an anti-cancer drug that organic chemists got busy trying to find ways to make a synthetic form of the compound in large enough quantities for clinical trials.
Developing an efficient synthetic route to natural product compounds and their analogs is often an essential step in drug development. With drugs such as penicillin and tetracycline, it can easily be done, but cryptophycins present more of a challenge. Sherman's team realized that with all cryptophycins, the most difficult step came very late in the synthesis, at the point at which a key part called an epoxide—a highly strained, three-membered ring oxygen-containing group, crucial for the drug's anti-cancer activity—becomes attached to the molecule.
The epoxide group can be attached in two configurations, designated as alpha and beta. Scientists have known for several years that the beta configuration was absolutely required for the anti-cancer properties of the drug, but were unable to devise efficient synthetic strategies that favored that configuration.
Sherman's team accomplished this by isolatiPage: 1 2 Related medicine news :1
. Fibroids unlikely to Turn Cancerous
. Virus Level could Predict Cervical Cancer Risk
. Cancer Doctors Okays Controversial Prostate Therapy4
. Potential New Cancer Gene Identified5
. Consensus on "Combination Therapy" for Breast Cancer
. Cancers of Colon & Rectum linked to Cigarette Smoking7
. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos8
. The Cancer Rumour mill working over time9
. Cancer drugs in development nearly doubled since 199510
. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body11
. Cancer patients turning to Internet for information