Navigation Links
Anthrax Attack - Greater Potential Threat Than Thought

A newly published study shows that more people were at risk of anthrax infection in the Oct. 2001 attack on U.S. Sen. Tom Daschle's office than previously known//. On the other hand, the study shows, prompt intervention with antibiotics and vaccination appeared to be highly effective against the disease.

The study results were published in the January 15 issue of The Journal of Infectious Diseases, now available online.

In October of 2001, a letter containing spores of Bacillus anthracis, the bacterium that causes the deadly disease anthrax, was opened in Daschle's office at the Hart Senate Office Building in Washington, DC. Those in or near Daschle's office, judged likely to have been exposed to the spores, received antibiotics or a vaccine, as did others within or outside the building, and no deaths resulted from this act of bioterrorism.

According to the new study of the event, however, people in areas assumed to be at minimal risk of exposure showed immune responses suggesting they had been exposed.

The researchers, Denise L. Doolan, PhD, MPH, Daniel A. Freilich, MD, and coworkers of the Naval Medical Research Center, Silver Spring, MD, and elsewhere, prospectively studied clinical outcomes and immune responses in 123 subjects including 83 people who were nearby when the letter containing the anthrax spores was opened; 20 who were outside the building and presumed to be unexposed; and, for comparison, six individuals vaccinated against B. anthracis, two confirmed to have had anthrax, and 12 with no known B. anthracis exposure.

The results: Immune responses occurred not only in subjects in or near the Daschle office but also in those elsewhere in the Hart building, or even outside the building; the extent of exposure was thus greater than predicted. No associations were seen between exposure levels and immune responses or symptoms, but the most-exposed subjects were the only ones to have high-magnitude responses .

Low-level exposure did not appear to trigger an antibody response, but did induce a response by cells of the immune system, Intermediate exposure induced both. Finally, cellular immune responses declined with post-exposure use of antibiotics, suggesting that the intervention impeded spore germination and implying that it may reduce the incidence of both subclinical and clinical B. anthracis infection.

In an accompanying editorial, James L. Hadler, MD, MPH, of the Infectious Diseases Section of the Connecticut Department of Public Health, commented that the study by Doolan and coworkers is "one of the few studies of the immune response to high-level, naturally occurring anthrax exposure in humans, and may be the first to describe cell-mediated responses to this pathogen."

Dr. Hadler said that the study's data suggest that cell-mediated responses in B. anthracis infection may be more sensitive than antibody responses, and he recommended that future studies of anthrax vaccines investigate cellular immunity's role in inhibiting the pathogen.

Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Anthrax drug doxycycline could stunt fetal growth
2. Drugs For Anthrax May Interfere With Oral Contraceptives
3. Cipro Has Cheaper Cousins to Treat Anthrax
4. Panacea Biotech To Market Anthrax Vaccine
5. Anthrax vaccine produced
6. Prototype Detector detects Anthrax Quickly
7. Effective And Economical Agent For Anthrax
8. Anthrax hammers immune system
9. Identifying Predictors Of Anthrax
10. New Inhalation Anthrax Vaccine
11. Anthrax Scare In Tamil Nadu State of India
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... 2016 , ... The medical profession is well aware that heart attacks do ... analyzing heart attacks among 138,602 people recorded a 35% higher number of heart attacks ... agree of course–no time of year is a good time for a heart attack! ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... 2016 BOC Business Brilliance Awards under the Best New Product Launch category. Gensuite’s ... achieved through user experience. , BOC Global Events & Training Group is a ...
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen McLaughlin, LA.c., a certified ... Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years of experience with fertility ... patients realize their family building goals. Acupuncture helps fertility patients by ...
(Date:12/7/2016)... ... December 07, 2016 , ... “Tomorrow Trump Goes To Washington”: a brief ... the presidency and to America. “Tomorrow Trump Goes To Washington” is the creation of ... can for this country. , Nancy attributes her patriotic nature to her WWII veteran ...
(Date:12/7/2016)... ... ... “Fred Rides a Train” allows readers to tag along on a special ... Train” is the creation of published author, Janet Morrison, who has been writing mostly ... "Fred, the Dog" series is her first attempt at writing for children. Janet, Fred, ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Inc. (NASDAQ: IONS ), the leader in antisense therapeutics, ... BMO Capital Markets Prescriptions for Success Healthcare Conference on Wednesday, December ... A live webcast of the presentation will be available on the ... be available within 48 hours and will be archived for a ... , , ...
(Date:12/7/2016)... PHILADELPHIA , Dec. 7, 2016  Lannett Company, Inc. (NYSE: ... at the BMO Capital Markets 2016 Prescription for Success Healthcare Conference ... Barclay hotel in New York City . ... investors participating at the Guggenheim Securities 4 th Annual Boston ... Boston hotel. ...
(Date:12/6/2016)... 2016  Alopexx Oncology, LLC announced data from a ... protein (immunocytokine) composed of interleukin-2 and a CD20-targeting monoclonal ... B cells as Rituxan and maintains the activities of ... involved in tumor targeting, engagement of the immune system, ... of the study (abstract #95954) were presented at the ...
Breaking Medicine Technology: