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Animal Research Uncovers Another Mechanism of Cholesterol Lowering Drug

that are stored in the gallbladder. Normally, most of biliary cholesterol is secreted from the body in the feces. However, when the bile contains too much cholesterol, gallstones can result. These hardened pieces of cholesterol can block the passageway from the gallbladder to the intestine, resulting in severe abdominal pain, liver damage and nutrient malabsorption.

The fact that Zetia works in two locations is positive because it makes it more effective as a cholesterol-lowering drug, said Temel. But our research suggests the potential for having too much cholesterol in the bile, which could possibly cause gallstones.

The researchers hope to study the question in monkeys and said more research is needed to see if the drug increases gallstone formation in some people. Until more research is done in animal models that naturally express the protein, it is difficult to say whether this would apply to humans, said Yu.


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