Navigation Links
Angioplasty may Damage Kidneys

Researchers from Wake Forest University Baptist Medical Center and colleagues has found that angioplasty-the most common procedure for clearing blocked kidney arteries can also release thousands of tiny particles into the bloodstream that can impair kidney function.

This is the first data in humans to show that debris released during angioplasty and stenting of the kidney arteries can be harmful to kidney function, said Matthew Edwards, M.D., M.S., lead researcher and an assistant professor of surgery. It raises important questions about how to most safely perform this very common procedure.

Edwards said that understanding more about potential complications from the procedure can lead to improved treatments. The study, reported in the current issue of the Journal for Vascular Surgery, suggests that having patients stop aspirin use before the procedure may lead to worse results.

It also shows that stent size is important and raises questions about whether blocking or filtering out the debris, known as emboli, may be effective in improving results.

New devices exist that may prevent the passage of this debris into the kidney and may lead to better patient outcomes, said Edwards. We are currently conducting a clinical trial to explore this question.

As many as 3.5 million Americans over age 65 years have blocked kidney arteries that can lead to severe high blood pressure and kidney failure. These patients have a greater risk of having heart attacks or strokes, becoming dependent on dialysis, or dying.

In some cases, blockages are cleared by inflating a balloon-like device inside the vessel (angioplasty) and inserting a stent to keep the vessel open. The procedure is performed on about 40,000 to 80,000 people a year. Bypass surgery on the arteries is also an option, but few centers offer the complex surgery.

Based on laboratory studies, researchers have suspected that ang ioplasty releases particles into the bloodstream presumably made up of bits of clot and fatty plaque material from the blockage. The goal of the current study was to count the particles and determine if they are associated with impaired kidney function after the procedure.

In 28 angioplasty cases, researchers used a protection device to temporarily block the vessel at the site of the angioplasty and stenting. After the procedure, and while the protection system was still in place, researchers took a small sample of blood trapped by the protection device. The artery was then aspirated and flushed out to remove any remaining particles.

Laboratory analyses found a mean of 2,000 particles captured per blood sample many of them large enough to block the small vessels in the kidney.

The more particles collected from a patient, the worse their kidney function, said Edwards. Patients with higher levels of particles in their blood were more likely to have decreased kidney function after the procedure. Poor kidney function after kidney artery stenting has been previously demonstrated by our group to be associated with increased risk of heart attack, stroke or death in the future.

The results raise an important question: since the protection device was in place for the procedures, and it is designed to remove particles from the vessel, why did patients who had high particle counts before the artery was flushed also have worse kidney function afterwards"

The researchers theorize that some blockages are more prone to releasing particles than others and that just putting the protection device in place releases particles that reach the kidneys.

The study raises many questions, including how well the protection device works and can we predict which plaques are more prone to release debris, said Edwards. We are currently conducting a clinical trial to try and answer these questions.

T he new study, funded by the National Institutes of Health, will compare results in procedures performed with and without a protection device. The goal of the research is to determine the best way to conduct angioplasty so that results are comparable to or better than surgery. The current research was supported by the National Institutes of Health.


Related medicine news :

1. Cholesterol Drug Helps After Angioplasty
2. Angioplasty Should be the Standard
3. The Success Rate Of Angioplasty In Female Patients Low
4. Angioplasty The Much Preferred Treatment Of Choice For Heart Attacks
5. Angioplasty death risk reduced by doubling drug dose
6. Angioplasty death risk reduced by doubling drug dose
7. A ray of hope in Angioplasty dilemma
8. Angioplasty plus stenting better than thrombolysis for elderly patients with AMI
9. Patients Fare Better With Doctors Who Do More Angioplasty Procedures
10. Researchers Begin Study To Find Out If Angioplasty Can Be Safely Done In Smaller Hospitals
11. Drug-Coated Stents Work Better In Diabetic Patients After Angioplasty
Post Your Comments:

(Date:11/30/2015)... , ... November 30, 2015 , ... MOSI recently added ... Sea along with Back to the Jurassic to their collection of interactive exhibits within ... created dynamic worlds that will allow guests to get closer than ever to a ...
(Date:11/30/2015)... ... 2015 , ... The world of hair transplants and restoration is filled with ... and procedures have been in use for many years and are among the most ... M.D. has utilized many of these methods over the years, he also keeps an ...
(Date:11/30/2015)... ... November 30, 2015 , ... On Saturday, October 24th, 2015, at the Mill ... fundraising event, a 5K walk known as “Making Strides Against Breast Cancer”. Patients and ... is also located in Battle Creek, joined in for this campaign that sought to ...
(Date:11/30/2015)... CA (PRWEB) , ... November 30, 2015 , ... The ... matters of personal styling. So why is it a national news story when Donald ... to Parsa Mohebi, M.D., because appearances count more than anyone wants to admit when ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to an article published November ... slightly unusual choice to show her Instagram followers that the praise that they were ... pre-mature. Saying that she didn’t “want to mislead any mommy's who just had babies ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015   Royal Philips ... the launch of Radiology Solutions, a fully integrated, ... Solutions comprises customized, data-driven practice management approaches that ... help radiology practices improve care delivery and reduce ... Radiological Society of North America Annual Meeting (RSNA) ...
(Date:11/30/2015)... , Nov. 30, 2015  IBA Molecular North ... and distribution of radiopharmaceuticals, announced that as of January ... Inc. (Zevacor Pharma). The decision to rebrand the company ... firm as well as its close relationship with Zevacor ... Illinois Health and Science (IHS). Peter ...
(Date:11/30/2015)... BOCA RATON, Fla. , Nov. 30, 2015 ... Public Research (the Institute) announced today that it ... a medical device start-up company with technology developed at ... based on publicly-funded research, and bridges early funding gaps ... -based universities and research institutions. ...
Breaking Medicine Technology: