Navigation Links
Angioplasty Reduces Long-term Cardiac Risk in Heart Patients With 'silent' Ischemia

When compared with intensive drug therapy, percutaneous coronary intervention (PCI, angioplasty) was more beneficial in reducing the long-term risk of major cardiac events among heart attack survivors with 'silent ischemia', according to a study.

Cardiac ischemia is caused by insufficient blood flow to the heart muscle tissue. Silent ischemia can occur without accompanying signs or symptoms of angina (chest pain due to inadequate supply of oxygen to the heart muscle), but can be detected by electrocardiogram (ECG) and other techniques.

Silent ischemia has been shown to predict adverse prognosis in patients after myocardial infarction (MI, heart attack), coronary artery bypass graft surgery, and PCI, with or without stenting, according to background information in the article. However, the effect of PCI on the long-term prognosis of patients with silent ischemia after a heart attack is not known.

Paul Erne, M.D., of the Division of Cardiology, Kantonsspital Luzern, Luzern, Switzerland, and colleagues conducted a randomized, unblinded, controlled trial from May 2, 1991, to February 25, 1997, to determine whether PCI compared with drug therapy improves long-term outcome of asymptomatic patients with silent ischemia after a heart attack.

A total of 201 patients with a recent heart attack, silent myocardial ischemia verified by stress imaging, and one- or two-vessel coronary artery disease took part in the study. Ninety-six patients underwent PCI, and 105 patients received intensive anti-ischemic drug therapy. All patients received 100 mg. per day of aspirin and a statin (cholesterol-lowering) drug. Follow-up ended on May 23, 2006.

Patients in the PCI group experienced 27 major adverse cardiac events during an average follow-up of 10.2 years. During the same period, 67 adverse cardiac events occurred in the anti-ischemic drug group. This corresponds to an absolute event reduction of 6.3 percent per ye ar. The rate of ischemia among patients in the PCI group was 11.6 percent at the final follow-up, compared with 28.9 percent among patients in the drug therapy group, despite fewer drugs.

'We found a persistent benefit of PCI compared with optimized drug therapy,' the authors report. 'This benefit became apparent only after two years of observation, with survival curves continuously diverging up to the final follow-up after ten years.'

'This is the first, to our knowledge, long-term outcome study of an invasive therapy compared with an intensive anti-ischemic drug therapy in asymptomatic patients with silent ischemia after a recent MI,' the authors write.

'Our findings argue for an ischemic-targeted approach to PCI among asymptomatic survivors of MI,' they conclude.


'"/>




Related medicine news :

1. Cholesterol Drug Helps After Angioplasty
2. Angioplasty Should be the Standard
3. The Success Rate Of Angioplasty In Female Patients Low
4. Angioplasty The Much Preferred Treatment Of Choice For Heart Attacks
5. Angioplasty death risk reduced by doubling drug dose
6. Angioplasty death risk reduced by doubling drug dose
7. A ray of hope in Angioplasty dilemma
8. Angioplasty plus stenting better than thrombolysis for elderly patients with AMI
9. Patients Fare Better With Doctors Who Do More Angioplasty Procedures
10. Researchers Begin Study To Find Out If Angioplasty Can Be Safely Done In Smaller Hospitals
11. Drug-Coated Stents Work Better In Diabetic Patients After Angioplasty
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals plc ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, ... of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ... (Eastern Daylight Time). As previously announced on ... a definitive merger agreement under which Jazz Pharmaceuticals has ...
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
Breaking Medicine Technology: