Navigation Links
Angioplasty Reduces Long-term Cardiac Risk in Heart Patients With 'silent' Ischemia

When compared with intensive drug therapy, percutaneous coronary intervention (PCI, angioplasty) was more beneficial in reducing the long-term risk of major cardiac events among heart attack survivors with 'silent ischemia', according to a study.

Cardiac ischemia is caused by insufficient blood flow to the heart muscle tissue. Silent ischemia can occur without accompanying signs or symptoms of angina (chest pain due to inadequate supply of oxygen to the heart muscle), but can be detected by electrocardiogram (ECG) and other techniques.

Silent ischemia has been shown to predict adverse prognosis in patients after myocardial infarction (MI, heart attack), coronary artery bypass graft surgery, and PCI, with or without stenting, according to background information in the article. However, the effect of PCI on the long-term prognosis of patients with silent ischemia after a heart attack is not known.

Paul Erne, M.D., of the Division of Cardiology, Kantonsspital Luzern, Luzern, Switzerland, and colleagues conducted a randomized, unblinded, controlled trial from May 2, 1991, to February 25, 1997, to determine whether PCI compared with drug therapy improves long-term outcome of asymptomatic patients with silent ischemia after a heart attack.

A total of 201 patients with a recent heart attack, silent myocardial ischemia verified by stress imaging, and one- or two-vessel coronary artery disease took part in the study. Ninety-six patients underwent PCI, and 105 patients received intensive anti-ischemic drug therapy. All patients received 100 mg. per day of aspirin and a statin (cholesterol-lowering) drug. Follow-up ended on May 23, 2006.

Patients in the PCI group experienced 27 major adverse cardiac events during an average follow-up of 10.2 years. During the same period, 67 adverse cardiac events occurred in the anti-ischemic drug group. This corresponds to an absolute event reduction of 6.3 percent per ye ar. The rate of ischemia among patients in the PCI group was 11.6 percent at the final follow-up, compared with 28.9 percent among patients in the drug therapy group, despite fewer drugs.

'We found a persistent benefit of PCI compared with optimized drug therapy,' the authors report. 'This benefit became apparent only after two years of observation, with survival curves continuously diverging up to the final follow-up after ten years.'

'This is the first, to our knowledge, long-term outcome study of an invasive therapy compared with an intensive anti-ischemic drug therapy in asymptomatic patients with silent ischemia after a recent MI,' the authors write.

'Our findings argue for an ischemic-targeted approach to PCI among asymptomatic survivors of MI,' they conclude.


'"/>




Related medicine news :

1. Cholesterol Drug Helps After Angioplasty
2. Angioplasty Should be the Standard
3. The Success Rate Of Angioplasty In Female Patients Low
4. Angioplasty The Much Preferred Treatment Of Choice For Heart Attacks
5. Angioplasty death risk reduced by doubling drug dose
6. Angioplasty death risk reduced by doubling drug dose
7. A ray of hope in Angioplasty dilemma
8. Angioplasty plus stenting better than thrombolysis for elderly patients with AMI
9. Patients Fare Better With Doctors Who Do More Angioplasty Procedures
10. Researchers Begin Study To Find Out If Angioplasty Can Be Safely Done In Smaller Hospitals
11. Drug-Coated Stents Work Better In Diabetic Patients After Angioplasty
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... 2017 , ... “The Communion of Saints: A Pastor’s Potpourri ... congregations across the United States. “The Communion of Saints” is the creation ... served congregations in seven states throughout his long career of devotion to the ...
(Date:3/23/2017)... Houston, Texas (PRWEB) , ... March 23, 2017 , ... ... their 3rd location in the greater Houston Area. The new location is located at ... St. Luke’s Hospital in Springwoods Village. This newest location will provide patients living in ...
(Date:3/23/2017)... ... 2017 , ... The IoT (Internet of Things) is revolutionizing the way the ... on businesses and individual consumers alike. Laboratories can maximize their profit margin by ... from $4 trillion to $11 trillion dollars by the year 2025. McKinsey expects the ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... March is ... that pack a punch when it comes to maintaining good health. Every day, two ... minutes, your kidneys filter every drop of your blood, eliminating waste, regulating fluid levels ...
(Date:3/23/2017)... PA (PRWEB) , ... March 23, 2017 , ... ... comprehensive educational training program owned and organized by HMP Communications Holdings, LLC, today ... program for physicians within its nationwide network of wound centers interested in becoming ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... - Industry Forecast to 2025" report to their offering. ... The Global Cryostat ... over the next decade to reach approximately $3.5 billion by 2025. ... for all the given segments on global as well as regional ...
(Date:3/23/2017)... DUBLIN , Mar. 23, 2017 Research ... Valve Devices Market: Analysis By Procedure, Replacement Procedure By Technique, Repair ... their offering. ... Global Heart Valve Devices Market is forecasted to grow at a ... heart valve devices is driven by rising aging population, growth in ...
(Date:3/23/2017)... and INDIANAPOLIS , March ... LLY ) and the William Sansum Diabetes Center ... of Latino people affected by diabetes through enhanced research, ... of diabetes and cardiovascular disease bears a disproportionate weight ... ," said David Kerr , M.D., FRCPE, ...
Breaking Medicine Technology: