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Ancient Ancestors Might Have Had a Clue to HIV

Scientist believe that humans distant ancestors won the battle against the now extinct virus 4 million years ago but it left the human species vulnerable to HIV today. AIDs one of the most dangerous diseases of the present century and one of the most researched one still leaves many questions unanswered about its origin.

Many researchers believe that the answers to the origin could be found in the jungles of central Africa. The understanding to the origin might lead to finding an effective treatment for AIDS.

Studying the antibodies in chimpanzee faeces have suggested that the virus jumped into humans from a Cameroonian population of chimps early in the last century. A separate group of chimps in Cameroon has infected a handful of locals with a nonpandemic version of HIV. Waste from wild gorillas suggests they are probably responsible for a third form of the virus.

Michael Emerman of the Fred Hutchinson Cancer Research Centre, in Seattle, describes how he and his colleagues looked at a different virus ( PtERV1) which was active about a million years after human lineage parted from the chimp one. It appears that ancient hominids successfully evolved immunity to that virus, but in doing so were somehow left defenseless against HIV.

The ancient virus, PtERV1, left relics of itself in the DNA of modern chimpanzees.

All primates make TRIM5alpha, which protects them from viruses in the same broad category as HIV. But each species makes a slightly altered version, making them immune to different combinations of such viruses. The type that rhesus macaques produce, for example, confers complete resistance to HIV; the sort made by baboons slows that viruss replication by 50-fold.

In fact, when geneticists first compared the genomes of humans against those of chimps, the biggest difference is the presence [in nonhuman primates] of this virus, PtERV1.There are about 130 copies in the genomes of ch
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