Navigation Links
Anaesthetics may Cause Brain Disorder in Elderly

Bhubaneswar: An Indian origin scientist in the US has reiterated that some general anaesthetics used in long operations may cause brain disorders// in elderly patients.

A study led by Pravat Mandal of the University of Pittsburgh Medical School, US, found that halothane and isoflurane - two anaesthetics that are inhaled - and the injected drug propofol cause symptoms of brain disorder.

These anaesthetics encourage the clumping of proteins in the brain that cause Alzheimer's, a progressive brain disorder that gradually destroys a person's memory and ability to reason and make judgments, said Mandal.

"I work on Alzheimer's, Parkinson's and dementia with Lewy body disease using the NMR scan and brain imaging. I do not know in particular what anaesthetics are used in India. However, the gaseous method is popular due to its cost," Mandal told IANS on e-mail.

"They may cause harm to elderly people," said Mandal, who is an assistant professor in the Department of Psychiatry at the university and did his Ph.D from the Indian Institute of Technology (IIT), Madras.

Anaesthetics are used to temporarily reduce or take away sensation so that surgical procedures can be performed without causing pain. They can be induced by drugs injected into a vein or through gases inhaled by the patient. These methods are often combined.

Mandal's study also found that halothane interacts directly with beta amyloid - the major constituent of amyloid plaques in the brains of people afflicted with Alzheimer's - to change its shape and increase the rate at which it binds with nearby proteins.

Just six hours of exposure to halothane was enough to trigger protein clumping similar to that seen in people with Alzheimer's, says the study that involved animals and laboratory tests.

"If the same thing occurs in humans, anaesthetics could lead to more amyloid plaques which may lead to earlier memory prob lems."

For long-term anaesthesia, physicians must pay attention to biophysical (non-clinical) research, he said.

While Parkinson's disease is a degenerative disorder of the central nervous system that often impairs the sufferer's motor skills and speech, dementia is progressive deterioration in intellectual function and other cognitive skills, leading to a decline in the ability to perform activities of daily living.

Similarly Lewy body disease is a kind of dementia caused by damage in the brain. It is similar to Alzheimer's.

The research by Mandal's team has also appeared in the New Scientist magazine.

Source-IANS
'"/>




Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Breast Cancer Surgery Causes Psychological problems
5. Arthritis Drug May Cause Liver Damage
6. Causes of weakness in the aged
7. Gene Mutation Causes Ovarian Failure
8. Does Radiation Cause Lung Cancer?
9. Chronic Diseases said to Cause Falls in the Elderly
10. Vision Loss Due To Diabetic Retinopathy a Major Cause Of Concern
11. Low Testosterone Levels the Cause Of Depression In Men
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
Breaking Medicine Technology: