Navigation Links
An Exploration into Erectile Dysfunction in Diabetics

An over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men according to a new study. It has been found that one particular simple sugar, present in increased levels //in diabetics O-GlcNAc, interferes with the chain of events needed to achieve and maintain erection and can lead to permanent penile impairment over time.

The findings could have valuable implications for new types of erectile dysfunction treatments targeting this mechanism of erection. The present study was targeted at finding whether high glucose in diabetes mellitus modifies the endothelial nitric oxide synthase (eNOS) enzyme, which is responsible for the achievement and maintenance of erection.

Erectile dysfunction is a common problem for more than half of men with diabetes and about 50 percent to 75 percent of diabetic men have erectile dysfunction to some degree, [a rate] about threefold higher than in non-diabetic men. This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra.

A study on rats has revealed that erection begins when a sexual stimulus activates the enzyme neuronal nitric oxide synthase (nNOS) that causes short-term release of nitric oxide (NO) at the nerve endings in the penis. This initial release of NO causes rapid and short-term increases in penile blood flow and short-term relaxation of the penile smooth muscle, initiating an erection.

The resulting expansion of penile blood vessels and smooth-muscle relaxation allows more blood to flow into the penis. This increased blood flow (shear stress) activates the eNOS in penile blood vessels causing sustained NO release, continued relaxation and full erection.

O-GlcNAc hinders this normal chain of events by inhibiting the activation of eNOS, and consequently reducing the release of NO and preventing the smooth muscle in the penis from relaxing. Witho ut this relaxation, there is no shear stress to stoke the production of more NO and therefore, no normal, sustained erection.

This information not only asserts the physiological relevance of hyperglycemia and how it affects erection but also provides insights into vascular disease using erection as a model.


'"/>




Related medicine news :

1. Erectile dysfunction (ED) signals vascular disease
2. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
3. Erectile Dysfunction Drug Viagra Launched In India By Pfizer
4. Cardiovascular Disease More Common Among Erectile Dysfunction Patients
5. Erectile Dysfunction Connected To Heart Disease
6. Statins For Erectile Dysfunction- An Alternative To Viagra?
7. Erectile Dysfunction Can Be Rectified By Healthy Way Of Life
8. Host of Benefits from Erectile Dysfunction Drugs
9. Erectile Dysfunction Linked with Smoking and Obesity – Study Report
10. South Africans Turn to Natural Remedies for Treating Erectile Dysfunction
11. HIV and Erectile Medications - No Link Found
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “The Journey: ... faced every danger possible to save lost souls in the Philippines. “The Journey: From ... Carole is a dedicated teacher of the Bible. She has taught all ages and ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
Breaking Medicine Technology: