Navigation Links
An Exploration into Erectile Dysfunction in Diabetics

An over-supply of a simple blood sugar could be a major cause of erectile dysfunction in diabetic men according to a new study. It has been found that one particular simple sugar, present in increased levels //in diabetics O-GlcNAc, interferes with the chain of events needed to achieve and maintain erection and can lead to permanent penile impairment over time.

The findings could have valuable implications for new types of erectile dysfunction treatments targeting this mechanism of erection. The present study was targeted at finding whether high glucose in diabetes mellitus modifies the endothelial nitric oxide synthase (eNOS) enzyme, which is responsible for the achievement and maintenance of erection.

Erectile dysfunction is a common problem for more than half of men with diabetes and about 50 percent to 75 percent of diabetic men have erectile dysfunction to some degree, [a rate] about threefold higher than in non-diabetic men. This is not the same type of erectile dysfunction seen in non-diabetics, and it is less effectively treated with conventional drugs like Viagra.

A study on rats has revealed that erection begins when a sexual stimulus activates the enzyme neuronal nitric oxide synthase (nNOS) that causes short-term release of nitric oxide (NO) at the nerve endings in the penis. This initial release of NO causes rapid and short-term increases in penile blood flow and short-term relaxation of the penile smooth muscle, initiating an erection.

The resulting expansion of penile blood vessels and smooth-muscle relaxation allows more blood to flow into the penis. This increased blood flow (shear stress) activates the eNOS in penile blood vessels causing sustained NO release, continued relaxation and full erection.

O-GlcNAc hinders this normal chain of events by inhibiting the activation of eNOS, and consequently reducing the release of NO and preventing the smooth muscle in the penis from relaxing. Witho ut this relaxation, there is no shear stress to stoke the production of more NO and therefore, no normal, sustained erection.

This information not only asserts the physiological relevance of hyperglycemia and how it affects erection but also provides insights into vascular disease using erection as a model.


'"/>




Related medicine news :

1. Erectile dysfunction (ED) signals vascular disease
2. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
3. Erectile Dysfunction Drug Viagra Launched In India By Pfizer
4. Cardiovascular Disease More Common Among Erectile Dysfunction Patients
5. Erectile Dysfunction Connected To Heart Disease
6. Statins For Erectile Dysfunction- An Alternative To Viagra?
7. Erectile Dysfunction Can Be Rectified By Healthy Way Of Life
8. Host of Benefits from Erectile Dysfunction Drugs
9. Erectile Dysfunction Linked with Smoking and Obesity – Study Report
10. South Africans Turn to Natural Remedies for Treating Erectile Dysfunction
11. HIV and Erectile Medications - No Link Found
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
Breaking Medicine Technology: