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An Anti-cancer Smart Bomb delivered using a Nanocell

A nanocell that can work like a smart bomb for cancer treatment is to be reported in Nature by MIT. The nanocell will work by penetrating into the tumor, seal the opening and then deliver the lethal dose of anti-cancer toxins like a ‘stealth bimb’.// This will leave the healthy cells unharmed.

The experiments currently done on mice cancer like melanoma and lung cancer have the potential of being a revolutionary form of drug delivery mechanism in cancers. The drugs that can kill cancer cells are available however they cannot be given in a high dose due to their side effects. However the double-acting, drug-packing "nanocell" can prove to be effective and safe and prolong survival of cancers.

This study reported in the July 28 issue of Nature has the following discussion:
"We brought together three elements: cancer biology, pharmacology and engineering," said Ram Sasisekharan, a professor in MIT's Biological Engineering Division and leader of the research team.

"The fundamental challenges in cancer chemotherapy are its toxicity to healthy cells and drug resistance by cancer cells," Sasisekharan said. "So cancer researchers were excited about anti-angiogenesis," the theory that cutting off the blood supply can starve tumors to death. That strategy can backfire, however, because it also starves tumor cells of oxygen, prompting them to create new blood vessels and instigate metastasis and other self-survival activities.

The next obvious solution would be combining chemotherapy and anti-angiogenesis-dropping the bombs while cutting the supply lines. But combination therapy confronted an inherent engineering problem. "You can't deliver chemotherapy to tumors if you have destroyed the vessels that take it there," Sasisekharan said. Also, the two drugs behave differently and are delivered on different schedules: anti-angiogenics over a prolonged period and chemotherapy in cycles.

"We designed the
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