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Amniocentesis Safer for Pregnant Women

cedure-related loss rate after midtrimester amniocentesis using patients who were recruited for aneuploidy screening. A total of 35,003 unselected patients were enrolled between 10 3/7 and 13 6/7 weeks of pregnancy and followed until the end of pregnancy. Two groups were derived- those who did or did not undergo amniocentesis. The rate of fetal loss was compared between these groups and the fetal loss rate less than 6 months of gestation was 1.0% and was not statistically different from the control group.

According to researchers, the procedure related loss rate after amniocentesis was 0.06%. Women undergoing amniocentesis were only 1.1 times more likely to have a spontaneous loss. Researchers concluded that the procedure related loss rate after midtrimester amniocentesis performed on patients in a contemporary clinical trial was 0.06%. There was no significant difference in loss rates between those undergoing amniocentesis and those not undergoing amniocentesis.

Aneuploidy is a chromosomal imbalance of one or a few chromosomes above or below the normal human chromosomal number of 46, which may lead a child to have abnormalities including Down Syndrome. Amniocentesis is the standard prenatal detection procedure for aneuploidy. It has been a standard clinical practice to test women using this procedure who are 35 years or older as well as women who are genetically predisposed for certain disorders.

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