Navigation Links
Ambiguous Efficacy Of Opioid Drugs In Chronic Inflammatory Joint Pain Relief

Endomorphins are highly powerful a tool for pain management, just as morphine, a problematic narcotic derived from the opium poppy. It has previously been found that endomorphins are able to sidestep concerns// of side effects by virtue of their hard-wired relationship to the body's own pain control receptors. Such receptors, known as u-opioids, appear to be highly sensitized to endomorphins, selectively drawing the natural analgesic to their target spots throughout the peripheral tissue of joints.

Recently a study, published in the October issue of Arthritis and Rheumatism, was conducted to determine whether peripheral administration of the endogenous - opioid peptide endomorphin 1 could reduce knee joint pain, using animal models of acute and chronic arthritis.

Researchers from the University of Calgary, Alberta, Canada looked at the effect of endomorphin 1 on both acute and chronic arthritis in male lab rats. After inducing inflammation in their right knee joints, the researchers treated the rats with endomorphin 1 at various points following the onset of knee arthritis -- either 48 hours post-inflammation during the acute stage of joint pain, or at the one-week or three-week point during the chronic stage.

At all stages of treatment, the electrical activity, or firings, of knee nerve-endings in response to an exaggerated rotation of the joint were measured. Nerve-ending readings were also taken among rats that did not have arthritic knees but were nonetheless also treated with endomorphin.

The researchers found that endomorphin treatment caused nerve activity -- and presumably any related pain -- to drop off by approximately 75% in both normal rats and those with acute arthritis of the knee. However, when injected one or three weeks after the onset of arthritis, endomorphin had no effect on nerve activity. Subsequent autopsies further revealed that beginning one week after induced knee joint inflamm
'"/>




Page: 1 2

Related medicine news :

1. Efficacy Of Meningitis C Vaccine
2. The Efficacy Of Allergy Shots Questioned
3. The Efficacy Of Newer Stents Questioned
4. The Efficacy Of Hormone Replacement Therapy Studied
5. Efficacy of fish oil supplements in pregnancy.
6. Efficacy of Omega 3 Fatty Acids Needs Wider Perspective
7. Thailand To Test Efficacy Of Stem Cell Technology
8. Efficacy Of Sports-Formulated Jelly Beans In Warding Off Fatigue To Be Studied
9. Indian And Chinese Doctors Join Together To Prove The Efficacy Of Herbal Drugs
10. New Study Shows Efficacy of AROMASIN on Early Breast Cancer
11. KADIAN Efficacy Not Affected by Alcohol Consumption
Post Your Comments:
(Date:12/17/2014)... RI (PRWEB) December 17, 2014 ... recognize private practices that have made outstanding and ... in support and progression of private practice physical ... American Physical Therapy Association. , On behalf of ... OCS, owner and CEO of Performance accepted the ...
(Date:12/17/2014)... Hill, IL (PRWEB) December 17, 2014 ... 2015 Awards celebrate the best of the best in ... The award is only given to communities and agencies ... through the SeniorAdvisor.com site. Of the nearly 100,000 providers ... this award. Winners of the SeniorAdvisor.com Best of 2015 ...
(Date:12/17/2014)... get more fruits and vegetables at school than they do ... is true for students from wealthier families. These findings ... a healthy boost to poor students, diets, according to the ... students all ate a similar amount of fruits and vegetables ... recently in the journal Preventive Medicine . ...
(Date:12/15/2014)... Grants Pass, OR (PRWEB) December 15, 2014 ... factors perceived by United States women as impacting skin ... – the “Four C’s of skin care.” Water and ... the conclusions in a recent article describing the survey ... her experience, every item in every category discussed would ...
(Date:12/15/2014)... December 15, 2014 SIMpalm, a leading ... Connect App” for iPhone for its client, which allows ... is a company, specialized in finding the right wine. ... engine that uses combined sensory, chemistry and wine information. ... a virtual “wine fingerprint.” Those wines that are close ...
Breaking Medicine News(10 mins):Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2
... 31 HEI, Inc. (Nasdaq: HEII ),( ... into an agreement,to sell substantially all of the ... Inc., a wholly-owned subsidiary of Dutch based Smartrac ... substantially all the assets of,the RFID division, including ...
... /PRNewswire-FirstCall/ - MDS Inc. (TSX: MDS; NYSE:,MDZ), a ... global life,sciences markets, announced today that Stephen P. ... at the Thomas Weisel Partners,Healthcare Conference in Boston ... Time. Interested parties may access the live ...
... ARNA ) announced today that the company is ... Conference on September,6, 2007 at 10:00 a.m. Eastern Time ... New York City. Jack Lief, Arena,s President,and Chief Executive ... company and its clinical development and discovery programs. ...
... Aug. 31 World Heart,Corporation (WorldHeart) (Nasdaq: ... support systems, today announced the appointment of,Mr. David ... Officer.,Mr. Richard Juelis, the departing CFO, will provide ... assist with the transition and with certain,specific projects. ...
... way toward screening people at risk for lung cancer ... from the University of Colorado say. , The most ... said researcher Wilbur A. Franklin, M.D., Professor of Pathology ... goal would be to develop screening techniques for lung ...
... reopen around the country, a new study finds that parents ... early as fourth grade. ,A review of national and statewide ... typical 4th graders, 10% have already had more than a ... the past year. While the numbers are small in the ...
Cached Medicine News:Health News:HEI, Inc. Announces Sale of RFID Division Assets 2Health News:Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 2Health News:Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 3Health News:WorldHeart Appoints David Pellone Chief Financial Officer 2Health News:New technique detects specific chromosomal damage, may indicate lung cancer risk 2Health News:Underage drinking starts before adolescence 2Health News:Underage drinking starts before adolescence 3
(Date:12/15/2014)... -- The Government of Ghana has endorsed a ... and Terumo BCT to respond to the emerging Ebola crisis within ... health system capacity to the citizens of Ghana ... Readiness and Resilience Initiative (GERRI) is a multi-agency effort designed to: ... possible arrival of the Ebola epidemic , Provide new blood ...
(Date:12/13/2014)... 2014 Research and Markets ( ... "Drug Injection Devices to 2020" report ... http://photos.prnewswire.com/prnh/20130307/600769 As new drugs become ... of health conditions, drug developers have increasingly pursued ... process and increase the efficiency and reliability with ...
(Date:12/13/2014)... HUNTSVILLE, Ala. , Dec. 12, 2014 /PRNewswire-USNewswire/ ... has purchased the HiSeq X Ten sequencing system ... will enable HudsonAlpha to produce and analyze genomic ... purchase stems from the Institute,s commitment to research ... The HiSeq X Ten provides unprecedented capacity, ...
Breaking Medicine Technology:Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 2Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 4Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 5Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 6Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3
... For the first time, the Integrated ... analytical, and post-analytical solution coupled with ... five major steps a sample undergoes ... between each one - it delivers ...
... four convenient formats to meet all clinical ... draping for any surgical procedure. All blankets ... up. , ,The precision, die-cut holes provide ... is soft against the patient's skin. Paediatric ...
... a more efficient way to control ... battery operated patient warming system, provides ... with a compact and better way ... surgical process. Its unique design combines ...
For use with WarmTouch® Warming Blankets for the prevention or treatment of hypothermia...
Medicine Products: