Navigation Links
Alzheimer's-linked apolipoprotein E produced by neurons, Gladstone study

underlying apoE4-related neurodegenerative disorders.’

‘ApoE expression can be detected with unprecedented sensitivity and resolution in these mice,’ explains Qin Xu, PhD, a Gladstone postdoctoral scholar and first author of the paper. ‘This mouse model, known as the 'EGFP knock-in,' is a new and extremely promising approach to monitor gene expression in vivo.’ ‘Our EGFPapoE reporter mice can be used to track apoE expression in any tissue at any stage of development,’ adds Huang. ‘They will be a valuable tool for investigating the normal functions of apoE and the regulatory mechanisms that govern its expression.’

Still to be determined is the exact mechanism by which apoE4 wreaks havoc on the brain, playing roles not only in Alzheimer's disease but also in a number of other neurological diseases. Studies in Huang's lab have revealed a possible scenario. It appears that apoE in neurons is subject to processing by an enzyme that clips off a portion of the protein, resulting in toxic fragments that escape the secretory pathway and enter the cytosol (the fluid portion of a cell's cytoplasm). Studies now underway at Gladstone and elsewhere indicate that those fragments may interfere with glucose metabolism in the mitochondria (small intracellular organelles responsible for energy production, among other functions), leading to mitochondrial dysfunction and neuronal cell death.

The paper, ‘Profile and Regulation of Apolipoprotein (Apo) E Expression in Central Nervous System in Mice with Targeting of Green Fluorescent Protein Gene to the apoE Locus,’ was authored by Aubrey Bernardo, David Walker, and Tiffany Kanegawa of the Gladstone Institute of Neurological Disease, Gladstone Institutes President Robert W. Mahley, and Xu and Huang. This work was supported in part by grants from the National Institutes of Heath and a postdoctoral fellowship from the John Douglas French Alzheimer's Foundation.

Soure: Eurekalert
'"/>




Page: 1 2

Related medicine news :

1. Three dimensional structure of apolipoprotein revealed
2. Anthrax vaccine produced
3. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
4. New drug for breast cancer prevention produced by Arimidex
5. Tamiflu substrate produced from Bioengineered Bacteria
6. Foods produced organically have better health value
7. Chicken produced in Oman is cheap, safe and nutritious
8. A new study surpasses Gene Therapy Hurdle
9. A question on study of Adult Stem Cell
10. Marijuana gateway theory strengthened by study of twins
11. Old theory of adaptation confirmed by new study
Post Your Comments:
(Date:8/1/2014)... According to the Suspension Revolution 2.0 PDF review recently updated ... women who want to get ripped abdominals within a few ... intense workouts that help blast fat and gain muscle fast. ... Revolution 2.0 program provides users with easy tips and advice ... that help keep fit and stay healthy . ...
(Date:8/1/2014)... Seattle, Wa (PRWEB) August 01, 2014 ... Sores Fast book review recently updated by Vkool.com, ... remedies for relieving symptoms of cold sores ... in the neck ,     A sore throat ... ,     Eating, drinking, and sleeping are uncomfortable ...
(Date:8/1/2014)... August 01, 2014 Over 20,000 entrepreneurs ... for the 2014 Market America | SHOP.COM International Convention ... 2014. The annual event will introduce new products, technology, ... into earning, and also feature a who’s who of ... America | SHOP.COM Executive Team, successful entrepreneurs and celebrity ...
(Date:8/1/2014)... The Journal of Neurosurgery is pleased ... the August issue entitled "Race Against the Clock: ... Hemorrhage." Authored by Peter Le Roux, MD, Charles ... and Alisa Schaefer, PhD, the 20-page supplement covers ... and methods in use for management of the ...
(Date:8/1/2014)... August 01, 2014 Fitness is something most ... effort. From walking around the block to biking ten or ... and easy to maintain throughout the year. The Forbes ... forward series which will feature special guests, tips to get ... in shape. The series will air on most popular cable ...
Breaking Medicine News(10 mins):Health News:Suspension Revolution 2.0 PDF Review Exposes Dan Long's Program For Building Muscle – Vkool.com 2Health News:Suspension Revolution 2.0 PDF Review Exposes Dan Long's Program For Building Muscle – Vkool.com 3Health News:Get Rid Of Cold Sores Fast Book Review Exposes Ellie Gadsby's Guide For Treating Fever Blisters – Vkool.com 2Health News:Get Rid Of Cold Sores Fast Book Review Exposes Ellie Gadsby's Guide For Treating Fever Blisters – Vkool.com 3Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 2Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 3Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 4Health News:Market America | SHOP.COM Set to Unveil Technology Enhancements and New Products at the 2014 International Convention 5Health News:Management of anticoagulant-associated intracerebral hemorrhage 2Health News:Management of anticoagulant-associated intracerebral hemorrhage 3Health News:Forbes Living to Air Fitness Forward Series 2
... London has developed a flat computer keyboard that it ... aureus (MRSA), one of a number of hospital-acquired infections ... ,MRSA, which is transmitted mainly by touch, is ... has developed antibiotic resistance to most penicillins. , ...
... diabetics feel the government could do a lot more to ... of people in the ivory tower to pressing healthcare issues, ... fifteen thousand syringes, a measure of the number of injections ... 10 years of life. ,Almost one hundred children ...
... the anger of children with behavioural problems, says a new ... of 28 boys (10 to 16 years old) studying at ... had fewer violent outbursts while taking daily doses of the ... ,In the six months prior to the trial, students ...
... the size of your paunch is directly related to the ... conducted by a medical expert of Indian origin. ,According ... Leicester, obesity has now become a worldwide epidemic. Its prevalence ... half of women and two-thirds of men in Britain are ...
... and Red Crescent Societies revealed their plan to expand ... Southern Africa to fight the dreaded disease. // ... expand its anti-AIDS drive. ,"With just a fraction ... Africa currently accessing prevention, care and treatment services, the ...
... suspected to be behind the Salmonella outbreak that has sickened ... fingerprinting has identified Salmonella enterica serotype Typhimurium as the cause ... Centers for Disease Control and Prevention (CDC), in a press ... non bloody diarrhea that may extend up to a week. ...
Cached Medicine News:Health News:New Flat Keyboard To Tackle Hospital Super Bug 2Health News:Massive expansion of Anti-AIDS programme in Southern Africa 2Health News:Tomatoes: Culprits of Salmonella outbreak 2
(Date:7/31/2014)... DIEGO, July 31, 2014 Tandem Diabetes Care®, Inc. ... manufacturer of the t:slim® Insulin Pump, today reported its financial ... In comparing the second quarter of 2014 to the ... to $10.3 million from $5.5 million , t:slim Pump ... In comparing six months ended June 30, 2014 ...
(Date:7/31/2014)... July 31, 2014 Nektar Therapeutics (Nasdaq: ... quarter ended June 30, 2014. Cash and ... million as compared to $309.1 million at March 31, 2014."The ... Nektar as we look forward to significant milestones for a ... President and Chief Executive Officer of Nektar. "The first of ...
(Date:7/31/2014)... , July 31, 2014 Rock Creek Pharmaceuticals, ... it has initiated the development of its lead molecule, ... that it has selected Quotient Clinical, The Translational Pharmaceutics ... (UK) to run its early development programs. ... Application (CTA) by the end of the third quarter ...
Breaking Medicine Technology:Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 2Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 3Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 4Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 5Tandem Diabetes Care Reports Second Quarter 2014 Financial Results 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 2Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 3Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 4Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 5Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 7Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 8Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 9Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 10Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 11Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 12Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 13Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 14Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 2Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 4
... SUNNYVALE, Calif., Feb. 28, 2011 /PRNewswire/ ... company developing innovative technologies in diabetes management, announced that ... Silicon Valley Bank and ... used to help complete clinical trials and commercialize POGO™, ...
... Feb. 28, 2011 Advanced Cell Diagnostics, Inc. ... study utilizing RNAscope™ technology to detect human papillomavirus ... head and neck cancer. HPV status determined by ... patient outcome and highly concordant with that determined ...
Cached Medicine Technology:Intuity Medical Secures $20M Credit Facility From Silicon Valley Bank and Oxford Finance Corporation 2Intuity Medical Secures $20M Credit Facility From Silicon Valley Bank and Oxford Finance Corporation 3ACD Announces Clinical Study Results Using its RNAscope™ Technology 2ACD Announces Clinical Study Results Using its RNAscope™ Technology 3
Icefire has ice crystals on the top of a cool blue iris....
This design features a solid red iris....
This pattern transform your pupils into narrow slits surrounded by eye stopping yellow. Works well with kitty-cat costumes....
This camouflaging lens features the solid black stripes of the lightning fast African zebra, on a white iris background....
Medicine Products: