Navigation Links
Alzheimer's-linked apolipoprotein E produced by neurons, Gladstone study

underlying apoE4-related neurodegenerative disorders.’

‘ApoE expression can be detected with unprecedented sensitivity and resolution in these mice,’ explains Qin Xu, PhD, a Gladstone postdoctoral scholar and first author of the paper. ‘This mouse model, known as the 'EGFP knock-in,' is a new and extremely promising approach to monitor gene expression in vivo.’ ‘Our EGFPapoE reporter mice can be used to track apoE expression in any tissue at any stage of development,’ adds Huang. ‘They will be a valuable tool for investigating the normal functions of apoE and the regulatory mechanisms that govern its expression.’

Still to be determined is the exact mechanism by which apoE4 wreaks havoc on the brain, playing roles not only in Alzheimer's disease but also in a number of other neurological diseases. Studies in Huang's lab have revealed a possible scenario. It appears that apoE in neurons is subject to processing by an enzyme that clips off a portion of the protein, resulting in toxic fragments that escape the secretory pathway and enter the cytosol (the fluid portion of a cell's cytoplasm). Studies now underway at Gladstone and elsewhere indicate that those fragments may interfere with glucose metabolism in the mitochondria (small intracellular organelles responsible for energy production, among other functions), leading to mitochondrial dysfunction and neuronal cell death.

The paper, ‘Profile and Regulation of Apolipoprotein (Apo) E Expression in Central Nervous System in Mice with Targeting of Green Fluorescent Protein Gene to the apoE Locus,’ was authored by Aubrey Bernardo, David Walker, and Tiffany Kanegawa of the Gladstone Institute of Neurological Disease, Gladstone Institutes President Robert W. Mahley, and Xu and Huang. This work was supported in part by grants from the National Institutes of Heath and a postdoctoral fellowship from the John Douglas French Alzheimer's Foundation.

Soure: Eurekalert
'"/>




Page: 1 2

Related medicine news :

1. Three dimensional structure of apolipoprotein revealed
2. Anthrax vaccine produced
3. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
4. New drug for breast cancer prevention produced by Arimidex
5. Tamiflu substrate produced from Bioengineered Bacteria
6. Foods produced organically have better health value
7. Chicken produced in Oman is cheap, safe and nutritious
8. A new study surpasses Gene Therapy Hurdle
9. A question on study of Adult Stem Cell
10. Marijuana gateway theory strengthened by study of twins
11. Old theory of adaptation confirmed by new study
Post Your Comments:
(Date:7/26/2014)... (PRWEB) July 26, 2014 ... recently updated by Vkool.com, this is a ... safe methods for treating all types of ...     Tinnitus due to Ménière's ... ,     Nerve pathway tinnitus , ...
(Date:7/26/2014)... The U.S. Food & Drug Administration (FDA) has released ... guide for AndroGel to include blood clots in the legs ... low testosterone medication, notes Wright & Schulte LLC. The ... low testosterone theapy drug, has also updated the official AndroGel ... signs of a blood clot in the leg and difficulty ...
(Date:7/26/2014)... 2014 According to the "Get Rid ... is a comprehensive guide that provides readers with safe ... This book also teaches them how to fade dark ... in their own home for drastic results. , ... Naturally" book includes step-by-step tutorials and product recommendations for ...
(Date:7/25/2014)... 2014 Deep Research Report ... Industry” is a professional and in-depth research ... Permeation Chromatography market. The report provides basic ... Chromatography definition, classification, application, and industry chain ... research covers the international market analysis, including ...
(Date:7/25/2014)... York, New York (PRWEB) July 25, 2014 ... dismissal and summary judgment in two DePuy Pinnacle hip ... paving the way for the claims to go before ... reports. In an opinion rendered on July 18th, U.S. ... Texas, ruled that the two Plaintiffs’ claims may proceed ...
Breaking Medicine News(10 mins):Health News:Tinnitus Miracle Book Review Exposes Thomas Coleman's Guide for Treating Tinnitus – Vkool.com 2Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 2Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 3Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 4Health News:FDA Updates AndroGel Risks to Include Blood Clots In Legs and Lungs as Testosterone Treatment Lawsuits Move Forward 5Health News:"Get Rid Tattoo Naturally" Book Review Exposes Jason Carter's Tattoo Removal Guide – Vkool.com 2Health News:"Get Rid Tattoo Naturally" Book Review Exposes Jason Carter's Tattoo Removal Guide – Vkool.com 3Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 2Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 2Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 4
... ... for their innovative solutions for reducing stress and improving health and well-being, is offering ... can be given as gifts. Their Beautiful Heart Award is expected to be very ... corner. , ...
... Feb. 4   When Mary Gill went to bed ... even Mary. She was thin and 42 years old. She exercised regularly, ... recipe for turning a young mom into a tragic statistic. , "Heart ... that night with an upset stomach, I wasn,t thinking heart attack." , ...
... , LACHEN, ... Octapharma USA will accept applications until ... , which supports clinical or pre-clinical research focused on human protein therapies ... reviewed in April. , Octapharma AG , one of the largest ...
... discovered unexpected properties for a precursor to melatonin, the ... from the neurotransmitter serotonin in a daily rhythm that ... previously thought to have effects separate from those of ... shown that N-acetylserotonin can stimulate the same circuits in ...
... National Heart, Lung, and Blood Institute (NHLBI), part of ... totaling $23.6 million to begin preclinical testing of devices ... those who develop heart failure. The four-year program is ... Each year in the United States, nearly 1,800 infants ...
... ... its Cryopak subsidiary in Maromme, France. Officially starting operations in March of 2009, Cryopak, ... scale to companies across Europe. , ... Edison, NJ (PRWEB) February 4, 2010 -- www.cryopak-europe.com-- TCP Reliable has ...
Cached Medicine News:Health News:HeartMath Offers Free Certificates that Celebrate Love and the Heart 2Health News:HeartMath Offers Free Certificates that Celebrate Love and the Heart 3Health News:Texas Health Dallas Launches Screening Program for Female Heart Disease 2Health News:Texas Health Dallas Launches Screening Program for Female Heart Disease 3Health News:Octapharma Accepting Applications for Research Grants Through March 31 2Health News:Octapharma Accepting Applications for Research Grants Through March 31 3Health News:Octapharma Accepting Applications for Research Grants Through March 31 4Health News:Melatonin precursor stimulates growth factor circuits in brain 2Health News:NHLBI funds preclinical tests on devices for infants and children with congenital heart defects 2Health News:NHLBI funds preclinical tests on devices for infants and children with congenital heart defects 3Health News:Cryopak France Opening Signifies New Vision for Global Manufacturing for the Cold Chain Industry 2
(Date:7/25/2014)... DIEGO , July 25, 2014  Arena Pharmaceuticals, ... will provide a corporate update and report second quarter ... opens on Friday, August 1, 2014. That same day, ... 8:30 a.m. Eastern Time (5:30 a.m. Pacific Time). ... dialing 877.643.7155 for domestic callers and 914.495.8552 for international ...
(Date:7/24/2014)... 2014  PTC Therapeutics, Inc. (NASDAQ: PTCT ... webcast conference call to report its second quarter 2014 ... business and outlook on Thursday, August 7, 2014 at ... The call can be accessed by ... minutes prior to the start of the call and ...
(Date:7/24/2014)... 2014  Uroplasty, Inc. (NASDAQ: UPI ), ... markets innovative proprietary products to treat voiding dysfunctions, ... first quarter ended June 30, 2014.  Global ... System grew 19% to $4.1 million, as compared ... the prior year.  Total revenue for the fiscal ...
Breaking Medicine Technology:Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3Uroplasty Reports Fiscal First Quarter Results 2Uroplasty Reports Fiscal First Quarter Results 3Uroplasty Reports Fiscal First Quarter Results 4Uroplasty Reports Fiscal First Quarter Results 5Uroplasty Reports Fiscal First Quarter Results 6Uroplasty Reports Fiscal First Quarter Results 7Uroplasty Reports Fiscal First Quarter Results 8Uroplasty Reports Fiscal First Quarter Results 9Uroplasty Reports Fiscal First Quarter Results 10Uroplasty Reports Fiscal First Quarter Results 11
... , REDWOOD CITY, Calif. , Jan. 28 Cardica, ... second quarter and six months ended December 31, 2009 . Cardica,s ... to discuss the financial results and provide an update on the ... sales model for our cardiac anastomosis products from a direct sales force ...
... , PLEASANTON, Calif. , Jan. 28 Thoratec ... support therapies to save, support and restore failing hearts, said today that ... 2009 led to a 19 percent increase in total 2009 revenues versus ... 2, 2010 , revenues were $373.9 million versus $313.6 ...
Cached Medicine Technology:Cardica Announces Fiscal 2010 Second Quarter Financial Results 2Cardica Announces Fiscal 2010 Second Quarter Financial Results 3Cardica Announces Fiscal 2010 Second Quarter Financial Results 4Cardica Announces Fiscal 2010 Second Quarter Financial Results 5Cardica Announces Fiscal 2010 Second Quarter Financial Results 6Cardica Announces Fiscal 2010 Second Quarter Financial Results 7Cardica Announces Fiscal 2010 Second Quarter Financial Results 8Cardica Announces Fiscal 2010 Second Quarter Financial Results 9Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 2Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 3Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 4Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 5Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 6Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 7Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 8Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 9Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 10Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 11Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 12Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 13Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 14Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 15Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 16Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 17Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 18Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 19Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 20Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 21Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 22Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 23Thoratec Reports a 19 Percent Increase in Annual Revenues as Cardiovascular Division Revenues Increase 30 Percent in 2009 24
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... panel mounted system that offers several unique design ... heath care professional using the system. It ... dual action lever that allows the system to ... pole. Similarly, it features a unique squeeze-lok(tm) ...
Stylish, comfortable and attractive, the new Keeler Sport frame is available in a choice of bright colors. The Keeler Sport frame can be worn over your own glasses, or your prescription can be incorp...
Medicine Products: