Navigation Links
Alzheimer's-associated Enzyme Linked to Seizures

Boffins have found that an enzyme beta-secretase or BACE, involved in the formation of the amyloid-beta protein linked with Alzheimer's disease can also alter neural activity in the brain , whose disruption might lead to seizures.

The study might put light on the high occurrence of seizures in Alzheimer's patients and suggests that treatments that might block this enzyme could lessen the incidences of seizures. Alzheimer's disease is marked by toxic amyloid-beta protein plaques in the brain which are formed when the larger amyloid precursor protein (APP) is clipped by two enzymes, BACE and gamma-secretase, which release the amyloid-beta fragment.

The study was conducted by a team of researchers led by Dora Kovacs at the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND). Earliers studies have shown that the BACE and gamma-secretase enzymes also work on the beta2 subunit of neuronal sodium channels.

Sodium channels comprise an alpha subunit, which forms the channel's body, and one or two beta subunits that checks the activity of the channel. Voltage-gated sodium channels transmit signalling impulses in nerve cells. As part of the study, to test how the processing of the beta2 subunit modify neuronal function, researchers conducted tests using brain tissue from animal models and from Alzheimer's patients after making sure that the beta2 subunit, similar to APP, can be acted on by BACE and gamma-secretase, releasing a portion of the beta2 molecule from the cell membrane.

The study found that increased levels of the free beta2 segment in the cell might increase the formation of the alpha subunits, but those molecules were not integrated into new sodium channels on the cell surface. The resulting scarcity of membrane sodium channels inhibited the path of neuronal signals into and through the cells.

"We have found a molecular pathway by which BACE can modulate the activity of sodium channe ls on neuronal cell membranes," Nature Cell Biology quoted Kovacs, as saying. Researchers suggested that sodium channel metabolism, whose dysfunction is known to cause seizures in both mice and humans is altered in the brains of Alzheimer's patients as compared with non-demented individuals of similar age.

"Our study suggests that the BACE inhibitors currently being developed to reduce amyloid-beta generation in Alzheimer's disease patients may also help prevent seizures by alleviating disrupted neural activity," Kovacs said.


'"/>




Related medicine news :

1. Enzyme may be target for obesity drugs
2. Researchers trick Alzheimers Enzyme
3. Enzyme stimulates growth of adult stem cells
4. Enzyme may aid hold back disease
5. Enzyme help destroy cancer cell
6. Enzyme Associated with Memory
7. Enzyme Associated With Memory
8. Brain Enzyme Found To Regulate Weight
9. New Enzyme Identified For Arthritis
10. Enzyme for treatment of arthritis
11. An Enzyme That Turns a One –time Experience into a long-time Memor
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... one of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. ... awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 10, 2017   West Pharmaceutical Services, Inc. ... injectable drug administration, today shared the results of a ... improving the intradermal administration of polio vaccines. The study ... in May 2017 by Dr. Ondrej Mach , ... Health Organization (WHO), and recently published in the journal ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
Breaking Medicine Technology: