Navigation Links
Alzheimer's-associated Enzyme Linked to Seizures

Boffins have found that an enzyme beta-secretase or BACE, involved in the formation of the amyloid-beta protein linked with Alzheimer's disease can also alter neural activity in the brain , whose disruption might lead to seizures.

The study might put light on the high occurrence of seizures in Alzheimer's patients and suggests that treatments that might block this enzyme could lessen the incidences of seizures. Alzheimer's disease is marked by toxic amyloid-beta protein plaques in the brain which are formed when the larger amyloid precursor protein (APP) is clipped by two enzymes, BACE and gamma-secretase, which release the amyloid-beta fragment.

The study was conducted by a team of researchers led by Dora Kovacs at the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND). Earliers studies have shown that the BACE and gamma-secretase enzymes also work on the beta2 subunit of neuronal sodium channels.

Sodium channels comprise an alpha subunit, which forms the channel's body, and one or two beta subunits that checks the activity of the channel. Voltage-gated sodium channels transmit signalling impulses in nerve cells. As part of the study, to test how the processing of the beta2 subunit modify neuronal function, researchers conducted tests using brain tissue from animal models and from Alzheimer's patients after making sure that the beta2 subunit, similar to APP, can be acted on by BACE and gamma-secretase, releasing a portion of the beta2 molecule from the cell membrane.

The study found that increased levels of the free beta2 segment in the cell might increase the formation of the alpha subunits, but those molecules were not integrated into new sodium channels on the cell surface. The resulting scarcity of membrane sodium channels inhibited the path of neuronal signals into and through the cells.

"We have found a molecular pathway by which BACE can modulate the activity of sodium channe ls on neuronal cell membranes," Nature Cell Biology quoted Kovacs, as saying. Researchers suggested that sodium channel metabolism, whose dysfunction is known to cause seizures in both mice and humans is altered in the brains of Alzheimer's patients as compared with non-demented individuals of similar age.

"Our study suggests that the BACE inhibitors currently being developed to reduce amyloid-beta generation in Alzheimer's disease patients may also help prevent seizures by alleviating disrupted neural activity," Kovacs said.


'"/>




Related medicine news :

1. Enzyme may be target for obesity drugs
2. Researchers trick Alzheimers Enzyme
3. Enzyme stimulates growth of adult stem cells
4. Enzyme may aid hold back disease
5. Enzyme help destroy cancer cell
6. Enzyme Associated with Memory
7. Enzyme Associated With Memory
8. Brain Enzyme Found To Regulate Weight
9. New Enzyme Identified For Arthritis
10. Enzyme for treatment of arthritis
11. An Enzyme That Turns a One –time Experience into a long-time Memor
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
(Date:6/24/2016)... Washington, D.C. (PRWEB) , ... June 24, 2016 , ... ... Pro-Am Heroes Golf Classic Tournament held on June 20th at the Woodmont Country ... local charity, Luke’s Wings, an organization dedicated to helping service members that have been ...
(Date:6/24/2016)... ... 2016 , ... Advanced Plastic Surgery Institute ( http://www.advancedplasticsurgeryinstitute.com ), ... official Medspa Sponsor. Dr. Josh Olson, a board-certified plastic surgeon, owns the practice, ... says the decision to support the pageant in an official capacity is a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
Breaking Medicine Technology: