Navigation Links
Alzheimer's-associated Enzyme Linked to Seizures

Boffins have found that an enzyme beta-secretase or BACE, involved in the formation of the amyloid-beta protein linked with Alzheimer's disease can also alter neural activity in the brain , whose disruption might lead to seizures.

The study might put light on the high occurrence of seizures in Alzheimer's patients and suggests that treatments that might block this enzyme could lessen the incidences of seizures. Alzheimer's disease is marked by toxic amyloid-beta protein plaques in the brain which are formed when the larger amyloid precursor protein (APP) is clipped by two enzymes, BACE and gamma-secretase, which release the amyloid-beta fragment.

The study was conducted by a team of researchers led by Dora Kovacs at the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND). Earliers studies have shown that the BACE and gamma-secretase enzymes also work on the beta2 subunit of neuronal sodium channels.

Sodium channels comprise an alpha subunit, which forms the channel's body, and one or two beta subunits that checks the activity of the channel. Voltage-gated sodium channels transmit signalling impulses in nerve cells. As part of the study, to test how the processing of the beta2 subunit modify neuronal function, researchers conducted tests using brain tissue from animal models and from Alzheimer's patients after making sure that the beta2 subunit, similar to APP, can be acted on by BACE and gamma-secretase, releasing a portion of the beta2 molecule from the cell membrane.

The study found that increased levels of the free beta2 segment in the cell might increase the formation of the alpha subunits, but those molecules were not integrated into new sodium channels on the cell surface. The resulting scarcity of membrane sodium channels inhibited the path of neuronal signals into and through the cells.

"We have found a molecular pathway by which BACE can modulate the activity of sodium channe ls on neuronal cell membranes," Nature Cell Biology quoted Kovacs, as saying. Researchers suggested that sodium channel metabolism, whose dysfunction is known to cause seizures in both mice and humans is altered in the brains of Alzheimer's patients as compared with non-demented individuals of similar age.

"Our study suggests that the BACE inhibitors currently being developed to reduce amyloid-beta generation in Alzheimer's disease patients may also help prevent seizures by alleviating disrupted neural activity," Kovacs said.


Related medicine news :

1. Enzyme may be target for obesity drugs
2. Researchers trick Alzheimers Enzyme
3. Enzyme stimulates growth of adult stem cells
4. Enzyme may aid hold back disease
5. Enzyme help destroy cancer cell
6. Enzyme Associated with Memory
7. Enzyme Associated With Memory
8. Brain Enzyme Found To Regulate Weight
9. New Enzyme Identified For Arthritis
10. Enzyme for treatment of arthritis
11. An Enzyme That Turns a One –time Experience into a long-time Memor
Post Your Comments:

(Date:11/24/2015)... Peoria, IL (PRWEB) , ... November 24, 2015 , ... Dr. Rodney E. Willey ... His new venture, Koala Center for Sleep Disorders, provides treatment for snoring and ... dentists who have opened a Koala Center for Sleep Disorders in the US, one of ...
(Date:11/24/2015)... ... November 24, 2015 , ... Bibliomotion is thrilled to ... Me about Reinvention and Diversity by Nancy M. Schlichting, Chief Executive Officer ... failing to adequately address the needs of patients and their families, shaped my desire ...
(Date:11/24/2015)... ... November 24, 2015 , ... World Patent ... Blending, a household invention that revolutionizes the vending machine industry by providing healthy ... is worth $2 billion," says Scott Cooper, CEO and Creative Director of World ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... announces Fragrance by Marcelle, a cosmetic invention which offers a combination of natural ... Market in the US is worth $3 billion annually," says Scott Cooper, CEO ...
(Date:11/24/2015)... ... , ... “I am so thrilled, as a newbie here, to leave a mark for the ... School Lounge Makeover® from California Casualty . Stephanie is in her fifth year teaching ... longer tenure. , “This is such an amazing school and we deserve a space where ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 2015 Sectra (STO: SECT B) ... into a multi-year agreement to deploy Breast Imaging ... provide the Breast Center a future-proof platform capable of ... SECT B) announces that Breast Center of Acadiana ... Breast Imaging PACS in its two freestanding imaging centers. This ...
(Date:11/24/2015)... 24, 2015  Ascendant Solutions, Inc. (Pink Sheets: ASDS ... of Directors has declared a special 1 percent stock dividend ... payable December 14, 2015, to shareholders of record December 7, ... additional shares of common stock. --> ... a strong endorsement of our confidence in Ascendant,s growth strategy ...
(Date:11/24/2015)... 2015 iRhythm Technologies, Inc. , a leading digital ... that it will participate in the 27th Annual Piper Jaffray Healthcare ... York, NY . Kevin King , Chief Executive ... 2015 at 8:50am ET. --> ... --> . --> iRhythm is a ...
Breaking Medicine Technology: