Navigation Links
Alzheimer's a new type of diabetes: Study

Recent research demonstrates that Alzheimer's disease represents a neuro-endocrine disorder that resembles a unique form of diabetes mellitus and progresses // with severity of neuro-degeneration.

In their study, to be published in the Journal of Alzheimer's Disease, researchers demonstrate that insulin and its receptors drop significantly in the brain during the early stages of Alzheimer's disease, and that levels decline progressively as the disease becomes more severe, leading to further evidence that Alzheimer's is a new type of diabetes.

Previous studies have shown that reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's disease (AD) and correlate with impaired cognition. Glucose utilization and energy metabolism are regulated by insulin and insulin-like growth factor I (IGF-I), and correspondingly, studies have shown that cognitive impairment may be improved by glucose or insulin administration.

Researchers from the Rhode Island Hospital and Brown Medical School analyzed postmortem brain tissue of 45 patients with a diagnosis of either normal aging or different degrees of Alzheimer's neurodegeneration, termed "Braak Stages."

The study mainly characterizes the abnormalities in insulin and IGF gene expression and receptor binding in brains with different Braak stage severities of AD.

Researchers analyzed insulin and insulin receptor function in the frontal cortex, a major area affected by Alzheimer's, and discovered that with increasing severity of the disease, levels of insulin receptors and the brain's ability to respond to insulin decreased markedly.

The two parallel abnormalities related to insulin in Alzheimer's found were that insulin levels decline as the disease progresses, and, that insulin and its related protein IGF-I lose their ability to bind to corresponding cell receptors, creating a resistance to the growth factors and thus causing cells t o malfunction and eventually die.

The authors stress that this could have important implications for treatment of this disease, and that being able to target the disease early, further loss of neurons could be prevented. However, they add that the resistance of its receptors in the brain, along with the loss of insulin will have to be targeted.

The researchers also found that acetylcholine deficiency, a hallmark of the disease, that is also associated with dementia, is linked directly to the loss of insulin and IGF-I function in the brain.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Decrease in testosterone levels lead to Alzheimers
3. Smokers are prone to Alzheimers
4. Over-The-Counter Drugs May Prevent Alzheimers
5. Alzheimers followed by head injury
6. Vitamin E useful for Alzheimers
7. Staying mentally energitic prevents Alzheimers
8. Researchers trick Alzheimers Enzyme
9. Drug Offers Hope for Alzheimers disease
10. Alzheimers with psychosis runs in families
11. Blood test may aid foretell Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/25/2017)... ... July 25, 2017 , ... Creative ... their partnership to provide the Pharmacist eCare Plan to Computer-Rx pharmacies ... country with the ability to develop the Pharmacist eCare Plan, a shared document ...
(Date:7/25/2017)... ... July 25, 2017 , ... Nautilus ... United States, today announced its partnership with financial technology company, Automated Transaction Delivery ... of the solution lies within Hyosung’s superior ATMs, assisted self-service devices and associated ...
(Date:7/25/2017)... , ... July 25, 2017 , ... SignatureCare Emergency Center ... the Austin, TX area 24 Hours a day. , The Emergency Room ... , “We’ve been open four months now and things are running smoothly,” said ...
(Date:7/24/2017)... ... ... SignatureCare Emergency Center is looking to award their 2017 Fall Scholarship. ... student. Get your applications in now as the deadline is approaching fast. ... a nursing student at Prairie View A&M University with a 3.45 GPA. Castillo was ...
(Date:7/24/2017)... ... July 24, 2017 , ... A four alarm ... construction site and threatened numerous homes and businesses nearby, causing some 700 individuals ... NBCLosAngeles.com. Los Angeles Area consulting firm Fire Protection Group, Inc. notes that the ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... , July 10, 2017  The tenth annual ... Boston, MA at the Sheraton Boston Hotel, ... unparalleled access to global decision makers and innovative biotech ... life science leaders during two impactful days. BioPharm America ... delegates with additional networking opportunities with 4,500+ life science ...
(Date:7/5/2017)... England , July 5, 2017 Wolfmet ... perfect answer as physics and manufacturing combine to progress molecular ... thyroid, existing SPECT systems are unable to accurately quantify the ... only limited information regarding the success of this radiotherapy treatment ... ...
(Date:7/5/2017)... 5, 2017   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade cell and tissue ... ("BioLife"), today announced that it has reached an agreement ... largest shareholder, to modify its existing credit facility effective ... modification, WAVI agreed to exchange its existing $4.25 million ...
Breaking Medicine Technology: