Navigation Links
Alzheimer's a new type of diabetes: Study

Recent research demonstrates that Alzheimer's disease represents a neuro-endocrine disorder that resembles a unique form of diabetes mellitus and progresses // with severity of neuro-degeneration.

In their study, to be published in the Journal of Alzheimer's Disease, researchers demonstrate that insulin and its receptors drop significantly in the brain during the early stages of Alzheimer's disease, and that levels decline progressively as the disease becomes more severe, leading to further evidence that Alzheimer's is a new type of diabetes.

Previous studies have shown that reduced glucose utilization and energy metabolism occur early in the course of Alzheimer's disease (AD) and correlate with impaired cognition. Glucose utilization and energy metabolism are regulated by insulin and insulin-like growth factor I (IGF-I), and correspondingly, studies have shown that cognitive impairment may be improved by glucose or insulin administration.

Researchers from the Rhode Island Hospital and Brown Medical School analyzed postmortem brain tissue of 45 patients with a diagnosis of either normal aging or different degrees of Alzheimer's neurodegeneration, termed "Braak Stages."

The study mainly characterizes the abnormalities in insulin and IGF gene expression and receptor binding in brains with different Braak stage severities of AD.

Researchers analyzed insulin and insulin receptor function in the frontal cortex, a major area affected by Alzheimer's, and discovered that with increasing severity of the disease, levels of insulin receptors and the brain's ability to respond to insulin decreased markedly.

The two parallel abnormalities related to insulin in Alzheimer's found were that insulin levels decline as the disease progresses, and, that insulin and its related protein IGF-I lose their ability to bind to corresponding cell receptors, creating a resistance to the growth factors and thus causing cells t o malfunction and eventually die.

The authors stress that this could have important implications for treatment of this disease, and that being able to target the disease early, further loss of neurons could be prevented. However, they add that the resistance of its receptors in the brain, along with the loss of insulin will have to be targeted.

The researchers also found that acetylcholine deficiency, a hallmark of the disease, that is also associated with dementia, is linked directly to the loss of insulin and IGF-I function in the brain.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Decrease in testosterone levels lead to Alzheimers
3. Smokers are prone to Alzheimers
4. Over-The-Counter Drugs May Prevent Alzheimers
5. Alzheimers followed by head injury
6. Vitamin E useful for Alzheimers
7. Staying mentally energitic prevents Alzheimers
8. Researchers trick Alzheimers Enzyme
9. Drug Offers Hope for Alzheimers disease
10. Alzheimers with psychosis runs in families
11. Blood test may aid foretell Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2017)... ... ... Viewers likely know Rob Lowe from such 80s hits as St. Elmo’s Fire and ... The West Wing and Parks and Recreation. But recently, Lowe’s leant his talents to ... on important modern-day issues that face today’s society. One of the most recent episodes ...
(Date:5/27/2017)... ... May 27, 2017 , ... Hate visiting the dentist? You should go twice per ... take care of your teeth at home. Here are some dental tips to help out: ... a small toothbrush in your work desk or a locker at school for a quick ...
(Date:5/27/2017)... ... May 27, 2017 , ... From May 21-23, hearing healthcare ... three-day event was held at the Marriott Syracuse Downtown Hotel in Syracuse, New York. ... and network of independent hearing healthcare providers to help them stay ahead in the ...
(Date:5/26/2017)... ... ... Mediaplanet is proud to announce the launch of its newest edition of ... on how to take care of all aspects of their skin. , On the ... with the Stars professional, Witney Carson, shares her journey with the disease that nearly ...
(Date:5/26/2017)... ... 26, 2017 , ... Leading CEOs from biotech, pharmaceutical, and ... 31st at The Four Seasons Hotel Boston. , The Boston CEO Conference ... exclusive access to key decision makers who influence deal making and investment. Attendees ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... CSSi, the global leader in patient recruitment, ... is proud to announce the launch of its newly ... both enriched content and a customized layout that provides ... already well-established position as the top global patient recruitment ... months of hard work, we are delighted to officially ...
(Date:5/9/2017)... 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... company focused on the development of oral drug ... Property Office has granted Oramed a patent titled, ... The patent covers Oramed,s invention of an oral ... an incretin hormone that stimulates the secretion of ...
(Date:5/8/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO)., has completed its acquisition ... care service center company based in Chantilly, ... management programs for leading pharmaceutical manufacturers and health care ... will join Envoy Health Management, LLC , as ... firms, and other service companies. Together, WRB and EnvoyHealth ...
Breaking Medicine Technology: