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Alternative Treatments for Arthritis

ort to be inaccurate and misleading.

The author points out that trials by pharmaceutical companies are designed to avoid the influence of confounders that could distort the true effect of the product being tested, and they are of a high quality since they must adhere to high standards in terms of study design, analysis and reporting. He also maintains that heterogeneity is common in meta-analyses of drug trials in OA, and is usually handled by subgrouping the trials based on common characteristics, which was not done in the Vlad study.

Regarding the studies that showed no effects, the author notes that they used unknown formulations of the dietary supplement glucosamine, whose inconsistency is well recognized. He notes that an analysis of three pivotal Rottapharm studies (two of which were performed by Reginster and his colleagues) showed results that were consistent and as clinically valid as other OA treatments.

Scientists should be careful when interpreting studies such as the one by Vlad and colleagues, Reginster concludes, adding that all forms of conflict by pharmaceutical companies and independent investigators should be assessed.


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