Navigation Links
Altered Sodium Channel Function Linked to Heart Failure

The results of a study, using mice and heart muscle cells from rabbits, by researchers from Georg-August-University G?ttingen, Germany, have provided// a potential molecular explanation for the abnormally rapid heartbeats known as ventricular tachyarrhythmias (VTs) that can cause the sudden death associated with heart failure.

Individuals who inherit mutations in genes regulating the influx of sodium ions (Na+) into the muscle cells of the heart through Na+ channels are predisposed to life-threatening VTs. So, because a protein known as calmodulin regulates Na+ channel function, and expression and activity of the calmodulin effector CaMKII is upregulated in humans with heart failure, Maier and colleagues investigated the effect of CaMKII on Na+ channel function. In this study, which appears online on November 22 in advance of publication in the December print issue of the Journal of Clinical Investigation, it was shown that overexpression of CaMKII in cultured heart muscle cells from rabbits and as a transgene in mice altered Na+ channel function. CaMKII mediated these effects by binding Na+ channel components and phosphorylating them. Importantly, mice overexpressing CaMKII were more susceptible to VTs than normal mice. These data lead the authors to suggest that CaMKII regulation of Na+ channel function might be a contributing factor to the onset of the potentially life-threatening VTs that are associated with heart failure.

Source-Eurekalert
'"/>




Page: 1

Related medicine news :

1. Women With Anorexia Have Altered Brain Activity
2. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
3. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
4. Schizophrenia Complicates With Altered Receptor Activity
5. The Immune System May Be Altered By Certain Chemicals
6. Gene-Altered Foods ? Still Not Sure
7. Gene-Altered Foods -Still Not Sure
8. Genetically Altered Cells Prevent Lethal Infections in Substituted Skin
9. Sodium nitrite salt intake found to increases blood flow
10. Americans Consume Far Too Much Salt and Sodium
11. Helicobacter pylori effectively killed by Sodium nitrite
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... Las Vegas, Nevada (PRWEB) , ... June 24, ... ... their Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and ... The Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
Breaking Medicine Technology: