Navigation Links
Allergic Reactions to Insulin Have Declined

A review of published research from the University of Liege, Belgium, reveals a decline in the number of people experiencing allergic reactions to insulin//. This is largely due to better purification of animal insulin and the introduction of human recombinant insulin.

The review also looks forward to the arrival of newly designed molecules that mimic the action of insulin while avoiding triggering an allergic response. In addition new modes of drug delivery, such as continuous subcutaneous insulin infusion (CSII), may help, and early reports suggest that CSII can help people who have previously had an allergic reaction to insulin.

In the 1950s and 1960s more than half of patients who used insulin experienced some form of allergic reaction. This has reduced considerably, but reports show that 0.1% to 3.0% of people still produce reactions that range from mild irritation to life-threatening incidents.

Originally insulin was harvested from animals, and advanced purification now makes this safer to use.

The gene for human insulin has been sequenced, and the sequence placed in bacteria. These modified organisms then produce the human insulin protein which can then be purified and used for therapy. Fewer people react to this 'recombinant insulin' because this is the human protein.

Now that scientists know the gene sequence, the shape of the insulin molecule, and the shape of the active site of the molecule, they can start to redesign it. The idea is to create a molecule that retains the action of insulin, but does not excite the human immune response system. This way it will be active, but will not cause an allergic reaction.

One potential reason for adverse reaction is that insulin is often injected in sudden doses. This gives unnaturally high peaks and troughs of the hormone. To avoid this variation, pumps have been developed that slowly infuse the hormone throughout the day. Early results on these pump s are promising.

"Our review shows just how much progress has been made in reducing allergic reactions to insulin, but more excitingly it shows that there are definite hopes of improving the situation even further," says lead author Regis Radermecker, who works at the Division of Diabetes, Nutrition and Metabolic Disorders at the University of Li├Ęge, Belgium.


Related medicine news :

1. Diet Can Influence Allergic Skin Reactions
2. New Treatment For People Allergic To Cats
3. Red Color Causes The Allergic Reaction To Strawberries
4. New Insight Gained For Allergic Reactions
5. Anthroposophical Lifestyle Reduces Risk Of Allergic Disease In Children
6. Allergic reaction to DTaP vaccine persists in children
7. Number of Allergic Anaphylaxis Episodes Are Far More Than Those Recorded
8. Eye Drug Macugen Shows Allergic Reactions
9. Allergic to Kisses?
10. Preventive Measures Proved Ineffective in Allergic Children
11. New Cooperative Research Center for Allergic Disease
Post Your Comments:

(Date:11/30/2015)... Juan, Puerto Rico (PRWEB) , ... November 30, 2015 , ... ... an active part of the San Juan Beauty Show held on November 8th and ... event was attended by media personalities, hair artists, renowned beauticians and top of the ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... their strategic partnership at the Radiological Society of North America (RSNA) 2015 ... global providers of cutting-edge dictation and speech-enabled documentation software, announced their partnership ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... announces the Unstoppable Swappables, a household invention that provides an economical and easy ... a year and is growing at 2.6%," says Scott Cooper, CEO and Creative ...
(Date:11/29/2015)... Clarkston, Metamora, Michigan (PRWEB) , ... ... ... Excellence is once again accredited by the American Institute of Ultrasound in ... that allows practices to demonstrate that they meet or exceed nationally recognized ...
(Date:11/29/2015)... ... 2015 , ... Khanna Vision Institute based in Los Angeles, announced that Dr. ... 2015. Peer Certification by the Board is done so the public knows that the ... obtained after the completion of three years of training or Residency in Ophthalmology. This ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... , Nov. 29, 2015   Royal Philips  ... driven radiology solutions at the 2015 Radiological Society of ... 4 at McCormick Place in Chicago ... will experience the company,s broad portfolio of integrated Diagnostic ... solutions to increase clinical performance, improve workflow and create ...
(Date:11/29/2015)... 29, 2015   National Decision Support Company (NDSC) ... base, including notable statewide implementations. As a result, ... ACR Select, more than 1 million times per ... ACR Select provides real-time feedback on the most ... has been implemented at over 100 healthcare systems ...
(Date:11/27/2015)... Nov. 27, 2015  Lannett Company, Inc. (NYSE: ... completed the acquisition of Kremers Urban Pharmaceuticals Inc. ... global biopharmaceuticals company UCB S.A. (Euronext: UCB). ... has acquired KU from UCB for total consideration ... including a customary working capital adjustment, a deduction ...
Breaking Medicine Technology: