Navigation Links
Age-Dependent Alterations Not Specific For Alzheimers Disease

Alzheimers disease (AD) has lately been suggested to be a systemic disorder, not confined only to the brain. An increasing volume of evidence indicates that AD is also associated with peripheral vascular changes //that might be important markers in tests of given pathophysiological hypotheses.

Researchers from the Faculty of Medicine, University of Szeged, Hungary, hypothesized that the onset of AD affects cholinergic microcirculatory patterns, and set out to compare the levels of spontaneous forehead and forearm flow motion in different age groups and to establish whether aging influences the rhythmic oscillation of the microvasculature. AD-specific alterations were also sought.

A total of 99 individuals were enrolled in the study. Oscillations in laser Doppler signals derived from the forehead and forearm skin were analyzed in 77 healthy probands from 4 various age groups (ranging between 15 and 77 years) and 22 late-onset sporadic AD patients.

A characteristic pattern of oscillations in the microcirculatory blood flux was observed in the forehead skin, the occurrence of which correlated inversely with age. The occurrence of forehead vasomotion pattern was 100% in the teenagers, whereas it was significantly less in the elderly control subjects (32%) and in the AD patients (18%).

Forearm reactive hyperemia was provoked by 1-min occlusion of the brachial artery, and the vascular reactivity was calculated. This phenomenon also proved to be age-dependent, but the process was not related to AD. Results indicate that the lack of forehead vasomotion reflects aging better than does the forearm vasomotion. Both of these functions are preserved in AD.

The novel findings from this study, which appears in the journal Microvascular Research (available online 14 October 2005) are that the forehead flow motion displays an age-dependent pattern. Also, under resting conditions, low-frequency oscillation in the forearm microcirculat ion was found in one-third of the subjects examined and no age-dependence was observed and occlusion of the brachial artery provokes flow motion in young, but not in elderly subjects. In addition, results indicate that the level of vascular reactivity decreases with aging, and there is no characteristic difference in the different flow motion patterns examined for AD patients.

Data from this study indicate that the oscillations in the microcirculation exhibit an age-dependent pattern, which is more pronounced in the forehead than in the forearm. These results furnish additional information characterizing the aging of the skin.
'"/>




Related medicine news :

1. Continual Fear Linked to Genetic Alterations in the Brain
2. Ape Humans? Alterations in Proteins Affects Genes.
3. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
4. Heart Drug Also Effective In Preventing Specific Causes Of Death
5. Specific Changes In A Particular Gene Found To Increase The Risk of Alzheimer’s Diseas
6. New Race –Specific drug
7. Developing Specific Skills Ensure Better Grades In US Kids
8. Specific Immune Mechanism against DNA viruses
9. The Publication Of Surgeon Specific Death Rates Raises Controversy
10. Timing of Food Consumption Activates Genes in Specific Brain Area
11. By Targeting Specific Germs, Hospital Hopes to Improve Pneumonia Treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is pleased ... Building 2. The clinic is the group’s second in New Braunfels and 22nd in ... second New Braunfels location brings things full circle for the group, “It’s crazy to ...
(Date:3/23/2017)... ... ... are unaware of the dangers that infectious bacteria play in mouth disease, while 1 out ... that dentists recommend. The ramifications of improper oral upkeep go far beyond bad breath and ... hours of work each year due to dental issues. That is why Mediaplanet is proud ...
(Date:3/23/2017)... ... March 23, 2017 , ... The StayWell Company announced ... The accreditation covers StayWell’s asthma, coronary artery disease, congestive heart failure, chronic obstructive ... that have excellent programs for the delivery and improvement of disease management and ...
(Date:3/23/2017)... ... March 23, 2017 , ... Michael Lanteri Agency, ... greater Fort Collins area, has unveiled a collaboration with nonprofit Big Bones Canine ... to this worthy cause may now be made at http://bigbonescaninerescue.com/ . , ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ?This conference will prominently feature 150+ Hospital and ... and Director, AMN Healthcare: Susan Salka , 43rd President of the United States ... Big Fight My Life In and Out of the Ring: Sugar Ray Leonard , ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017 CENTRO DE IMAGEM DIAGNOSTICOS ... paragraph 4 of Law 6,404/76 and Instruction 358/02 of ... its shareholders and the market in general that it ... Centro de Diagnosticos por Imagem Ltda. (" CDI "), ... in RADIOLOGISTAS ASSOCIADOS LTDA. (" Partnership " and " ...
(Date:3/23/2017)... , March 23, 2017  The goal ... system to identify and track prescription drugs as they ... , in response to requirements from US FDA to ... of potentially dangerous medicines. Blockchain startup ... cryptographic identity chips and blockchain technology and recently raised ...
(Date:3/23/2017)... , March 23, 2017  Cornerstone Pharmaceuticals, ... a major milestone today.  Following successful End-of-Phase ... U.S. Food and Drug Administration (FDA), the ... and regulatory path forward to conduct pivotal ... patients with acute myeloid leukemia (AML) and ...
Breaking Medicine Technology: