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African-Americans With Prostate Cancer More Likely to Have Family History

African-American men with prostate cancer were more likely to report a family history of prostate cancer and breast cancer among siblings than men who did not have prostate// cancer, according to researchers at the University of Michigan Comprehensive Cancer Center.

The data were part of the Flint Men’s Health Study, a population-based study of African-American men ages 40-79 who live in Flint, Mich. The Flint Men's Health Study focuses specifically on African-American men as part of an effort to determine why they face a higher risk of prostate cancer than white men.

The findings from this study support previous studies that have found increased risk of prostate cancer among men reporting a brother diagnosed with the disease. Furthermore, breast cancer diagnosed among both sisters and mothers of men with prostate cancer was more often diagnosed at a younger age, suggesting premenopausal breast cancer. Both breast and prostate cancer typically occur in older populations. Results of the study appear in the November issue of Urology.

Some 121 men with prostate cancer completed surveys about their family history of cancer, including prostate cancer among the men in their family and breast cancer among the women. Another 179 control men without prostate cancer were also surveyed.

Men with prostate cancer were 4.8 times more likely to report having a brother diagnosed with prostate cancer and about four times more likely to report a sister diagnosed with breast cancer, the researchers found.

“Previous studies have suggested having a brother with prostate cancer confers higher risk than another relative, such as a father or son. But this is the first time a link has been shown between sisters with breast cancer and prostate cancer risk among African-American men,” says lead study author Jennifer Beebe-Dimmer, MPH, Ph.D., assistant research scientist and lecturer in the Department of Epidemiology at the U-M School
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