Navigation Links
African-Americans Have A Reduced Response To Hepatitis C Treatment

According to a new study by Duke University Medical Center researchers, African-Americans have a notably lower response in the rate of treatment //for chronic hepatitis C than non-Hispanic whites.

The researchers had reported in the August issue of Gastroenterology, which is the journal for the members of the American Gastroenterological Association (AGA), that the African American patients with hepatitis C (HCV) infections experience a reduced response in the rate in treatment with peginterferon alfa-2a and ribavirin combination treatment than Caucasian Americans. They explained that the so-called racial differences in viral responses might be seen as the fourth week of treatment. It was further explained that pegylated interferon combined with ribavirin is standard therapy for HCV.

Researchers from the Study of Viral Resistance to Antiviral Therapy for Chronic Hepatitis C (Virahep-C), which is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducted the study to determine the potential mechanisms of antiviral resistance among patients who fail to respond to current optimal therapy regimens. While African Americans have a higher prevalence of HCV infection, they have been underrepresented in most therapeutic clinical trials, making it difficult to estimate response rates in these patients.

According to Charles Howell, MD, associate professor of medicine, University of Maryland School of Medicine and chairperson of the Virahep-C Study Group Steering Committee, "The basis for the racial difference in virologic response rates is being addressed by ongoing supplementary studies in genetics, immunology, interferon signaling and pharmacology, and virology. However, our study results indicate that the reduced response rate among African American patients is not caused by the usual predictors such as patient age, gender, pretreatment serum HCV concentrations, amount of fibrosis in the liv er biopsy nor amount of medication taken."

Study results showed that sustained virologic response (SVR), the primary endpoint, was significantly lower in African Americans compared with Caucasians (28 percent vs. 52 percent; P<.0001). Patients with SVR had not shown evidence of HCV RNA in their blood 24 weeks after the end of treatment. At treatment week 24, 46 percent of African Americans compared with 74 percent of Caucasian patients were HCV RNA negative and were eligible to continue on therapy to 48 weeks. While breakthroughs in virologic response during treatment were more common among African Americans than Caucasian patients (13 percent vs. 6 percent), the relapse rates after treatment were comparable (32 percent vs. 25 percent).

Data indicated that the proportion of the total maximum dose taken of both peginterferon and ribavirin during the first 24 weeks of treatment was significantly less in African Americans versus Caucasian patients; 54 percent of African American patients compared with 73 percent of Caucasian patients took at least 80 percent of the maximum doses of both peginterferon and ribavirin (P<.0001). However, this did not account for the racial difference in SVR rates.

African American and Caucasian patients experienced similar serious adverse events, dose reductions and drug discontinuations. Three deaths were included in the serious adverse events for African American patients – two deaths were considered unrelated after therapy had stopped, and one death occurred during therapy, possibly related to the peginterferon treatment.

Study Design Patients were treated for up to 48 weeks with peginterferon alfa-2a (Pegasys?) 180 μg/wk and ribavirin (Copegus?) 1000 or 2000 mg/day based on body weight of 75 kg or less. Patients were monitored at one to two week intervals for the first eight weeks, then every four weeks through the end of the study. Virologic response was assessed at week 24, and treatment was stopped in patients who had a positive test for serum HCV RNA. Responders continued treatment for another 24 weeks and were assessed for sustained virologic response at 24 weeks after treatment completion.

The study enrolled 401 patients (196 African Americans and 205 Caucasian Americans) who were treated at eight U.S. clinical centers between July 2002 and December 2003. Both groups were similar in terms of sex, age, estimated duration of infection, suspected source of infection and alcohol use. African American patients had a higher body weight and were more likely to have a history of diabetes and hypertension. African Americans were also more likely to have genotype 1b and less likely to have genotype 1a.

According to a second study published in the August issue of Gastroenterology, "non-Hispanic black race [is] the important predictor of genotype 1, and among persons infected with subtypes 1a and 1b, older age and non-Hispanic black race were the important predictors of genotype 1b...genotype1 and non-Hispanic black race, have been associated with a reduced response to antiviral therapies."^

Hepatitis C Surveys indicate that 1.3 percent of the U.S. population; approximately 3.2 million Americans have chronic HCV. Chronic HCV is the leading cause of chronic liver disease and the most common indication for liver transplants in the U.S. HCV-related cirrhosis (disruption of normal liver function caused by various chronic progressive conditions) accounts for almost 50 percent of newly diagnosed liver cancers and approximately 10,000 deaths per year.

Source: EurekAler.
'"/>




Related medicine news :

1. African-Americans Pose Less Questions To Treating Doctors
2. African-Americans With Prostate Cancer More Likely to Have Family History
3. Colorectal Cancer Survival Rates Poorer in African-Americans
4. Cancer Death Rates High in African-Americans
5. Reduced POD linked to fatal asthma attacks
6. Reduced fertility in men who mountain bike
7. Reduced Fatigue Boosts Mental Health
8. Rejection Rate for Liver Transplants Patient Reduced
9. Calcium-Vitamin D Combo For Reduced Fracture Risk
10. Heart Disease In Women Can Be Reduced By Eating Grapes
11. Cholesterol; Can Be Reduced By Sunflower Seeds, and Pistachios
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... (PRWEB) , ... May 28, 2016 , ... SuperCloset is ... all too well the day to day issues, struggles and obstacles veterans’ need to ... Helping Veterans Grow Project provides active or retired military veteran(s) with a donated SuperCloset ...
(Date:5/28/2016)... ... May 28, 2016 , ... May 26, 2016- In ... Arts Fighting Challenge with theme event of “K Warriors” on June 4, 2016 at ... , The event is sponsored and hosted by Shaolin Institute and sanctioned by ...
(Date:5/28/2016)... ... May 28, 2016 , ... In a part of the city where’s it’s easy to spot ... Kelowna restaurants is hoping to attract diners with a taste for real food. ... opened the doors to Cornerstone Grill, an urban casual restaurant focusing on dishes made by ...
(Date:5/27/2016)... ... May 27, 2016 , ... Southland Log Homes , designer ... timber frame barn kits, which can be found on its website at SouthlandLogHomes.com. , ... barn plans, and they highlight the craftsmanship of timber post and beam construction. ...
(Date:5/27/2016)... New Hampshire (PRWEB) , ... May 27, 2016 , ... ... skin care products, announced today that it has been recognized as one of the ... entering parenthood. Badger was named as one of nine small businesses providing progressive benefits ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 2016 TARE (Transarterial Radio-embolization) ... Savings and Overall Decreased Use of Hospital ... international specialist healthcare company, has today announced the ... Meeting of ISPOR (International Society for Pharmacoeconomics and ... (HCC) using yttrium-90 glass microspheres is associated with ...
(Date:5/25/2016)... 25, 2016 According to a ... (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), ... (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to 2021", ... Animation Market for the forecast period of 2016 to ... Million by 2021 from USD 117.3 Million in 2016, ...
(Date:5/25/2016)... , May 25, 2016  According to Kalorama ... $381 billion in 2015.  Though these are challenging ... of opportunity for success for companies that remain ... search of new growth prospects medical device companies ... research and development (R&D) than do companies in ...
Breaking Medicine Technology: