( ology of Colorectal Cancer project whi...)Advancement in Gene Associated With Colon Cancer,Health

ology of Colorectal Cancer project, which for 10 years has searched for clues to colon cancers genetic roots using samples from large numbers of people in Israel with known ancestral heritage. The project is funded by the National Cancer Institute, with additional funding from the Irving Weinstein Foundation.

The researchers compared the genetic makeup and family history of more than 1,800 colorectal cancer patients with that of 1,900 healthy people with the same breakdown of age, gender and ethnicity - either Ashkenazi Jew, Sephardic Jew or Arab/non-Jew.

Samples of tumor tissue from many cancer patients were also tested. The genetic link between the marker and colon cancer was especially strong among patients diagnosed with colon cancer at a young age, under 50 years.

Stephen Gruber, M.D., Ph.D., the co-leader of the Michigan-Israeli team and first author of the new paper, says that the new finding is particularly interesting when considered alongside recent discoveries in the genetics of prostate and breast cancer.

The same genetic region that predisposes to colon cancer has also recently been shown to be an important region predisposing to breast cancer and prostate cancer, he says. The specific genetic cause for this joint susceptibility to three different cancers has not yet been discovered, but several groups are working to close in on the mechanism that might cause these cancers.

Gruber is an associate professor of internal medicine and of human genetics in the U-M Medical School, and of epidemiology in the U-M School of Public Health. He directs the Cancer Genetics program in the U-M Comprehensive Cancer Center, which focuses on inherited cancer risks.

Genetic discovery in Israel through MECC has already proven highly informative. Senior author Gad Rennert M.D., Ph.D., of the Carmel Medical Center and the B. Rappaport Faculty of Medicine at Technion in Haifa, Israel, says The st
'"/>




Page: 1 2 3 4
Related medicine news :

1. Ingenious Biodegradable Heart Stent May Dictate Advancements in Heart Stent Technology
2. Protein Reduction Ceases Alzheimers Advancement in Mice
3. Protein Reduction Ceases Alzheimers Advancement in Mice
4. Advancement in DNA Research may Bring Back Woolly Mammoth
5. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
6. Bayer Voluntarily Withdraws BAYCOL - A Drug Associated With 50 Deaths
7. Associated therapy for multiple myeloma
8. Associated scan for detecting ovarian cancer spread
9. Ginseng Associated with Pregnancy Risks
10. Enzyme Associated with Memory
11. 3 die, 500 sickened in nations largest hepatitis A outbreak Associated Press