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Adenoviruses Could Help Kick Drinking

A single injection of a type of virus known as adenoviruses can help give up the habit of drinking, a study indicates.

Researchers have found that rats bred to crave alcohol were found to drink 50 percent less for more than a month after being injected with engineered adenoviruses.

Many people in East Asia react badly to alcohol because of mutations in the gene for aldehyde dehydrogenase. But these mutations also reduce the risk of succumbing to alcoholism by two-thirds or more.

Aldehyde dehydrogenase is blocked by the drug disulfiram, also known as Antabuse, which is sometimes used to help alcoholics quit the habit, said online edition of New Scientist.

"But you have to take it (disulfiram) every day, so there is a big problem with compliance," says researcher Amalia Sapag at the University of Chile in Santiago.

To provide a longer-lasting effect, scientists engineered adenoviruses to carry an "antisense" version of the aldehyde dehydrogenase gene that blocks the production of enzyme involved in alcohol metabolism.

A single injection reduced the enzyme's activity in rats' livers by 80 percent, Sapag revealed at the American Society of Gene Therapy meeting in Seattle earlier this month.


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