Navigation Links
Adalimumab Proves Effective for Children with Juvenile Rheumatoid Arthritis

Adalimumab, an injectable anti-TNF therapy that has FDA approval for treating rheumatoid arthritis in adults, has proven effective in children with juvenile rheumatoid// arthritis, according to research presented this week at the American College of Rheumatology Annual Scientific Meeting in Washington, DC.

The immunosuppressant adalimumab, currently used to treat adults with moderate to severe rheumatoid arthritis, targets inflammation by blocking TNF (tumor necrosis factor) proteins in the body. Following studies that demonstrated safety and effectiveness in adults with rheumatoid arthritis, this study in children with juvenile rheumatoid arthritis was performed. Juvenile rheumatoid arthritis affects an estimated 285,000 children in the U.S. The disease, which starts before they reach age 16, can cause joint stiffness, reluctance or refusal to use arms or legs, reduced activity levels, persistent pain and joint swelling. If not effectively treated, it can result in joint damage, growth delay and decreased bone mineralization.

To assess the long-term effectiveness and safety of adalimumab in a younger population, researchers conducted a 48-week randomized study on 171 children, ages 4 to 17, with five or more swollen joints and three or more joints with limited range of motion at the outset of the study. The subjects were categorized as those taking and not taking methotrexate at the beginning of the study. The dose of methotrexate and all other arthritis medications remained stable throughout the trial. Adalimumab doses were based on the child’s size, with participants receiving 24 mg/M2 BSA, maximum of 40 mg, given as a subcutaneous injection every 2 weeks over a 16-week period. At the end of the 16 weeks, the 83% (142) of the subjects who met the definition of “responder” for this study were randomized into a double-blind study and assigned to either continue adalimumab or switch to a placebo for the next 32 weeks or until disease flare-u
'"/>




Page: 1 2

Related medicine news :

1. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
2. Study Proves That MMR Vaccine Is Not Connected To Autistic Babies
3. Pilot Study Proves Home Abortions ‘Safe’
4. Many Nonprescription Cough Medicines Proves Ineffective
5. Less Invasive By Pass Surgery Proves Economical In The Long Run
6. Epidural Mistakes Proves To Be Fatal Blunders
7. Combined Anti-Fever Drug Therapy Proves Unsafe for Childhood Fever
8. Drug Trial Proves Nightmare for British Indian Student
9. Naturopathic Care Proves Beneficial for TMD Pain
10. Medtronic Device Proves Effective in Parkinson’s Diseas
11. Large Community Spirometry Screening Proves Successful
Post Your Comments:
(Date:9/16/2014)... (PRWEB) September 16, 2014 ... information media site, launches their new site today. ... additional features aimed at making information easier to ... sift, we distill into one-page, easy-to-read pages the ... should know!” says Virginia Downie, retired college professor ...
(Date:9/16/2014)... 2014 The Living Ethics lecture series ... Reflecting on what it means to live in an ... unique and thought-provoking topics. , “The Museum’s job is ... look at their world differently. The Living Ethics ... for truly enlightening dialogue,” says Richard Conti, Chief Wonder ...
(Date:9/16/2014)... Banish headaches forever with the newest ... device for chronic migraine relief and treatment. Cefaly was ... States. Until now, US patients would directly place their ... and wait 2-3 weeks for their device to arrive. ... and once prescription and payment is received, the Cefaly ...
(Date:9/16/2014)... Recently, BamboofloorChina.com, a famous online supplier of bamboo products, ... bamboo panels . The firm is now offering ... its high quality items. Please note that the big ... 2014. , According to the company’s chief executive ... should visit BamboofloorChina.com before September 28. BamboofloorChina.com is offering ...
(Date:9/15/2014)... 16, 2014 Career Step, an ... training, is pleased to announce that Panacea Healthcare ... PCS comprehensive skill assessments and the ICD-10-CM and ... and Panacea’s consulting division. , “We are excited ... ICD-10 to our clients,” said Suzanne Lappen, Panacea ...
Breaking Medicine News(10 mins):Health News:JustThoughtYouShouldKnow.org Debuts New Website 2Health News:Expanding Community Vision at the Science Museum of Virginia 2Health News:Cefaly Migraine Treatment Device Now Readily Available For Widespread Purchase in United States 2Health News:Cheap Bamboo Panels Unveiled By Famous Online Supplier BamboofloorChina.com 2Health News:Panacea Healthcare Solutions to Resell Career Step’s ICD-10-CM and PCS Assessments and Case Studies 2Health News:Panacea Healthcare Solutions to Resell Career Step’s ICD-10-CM and PCS Assessments and Case Studies 3
... more attention be paid after hospital discharge, , , MONDAY, ... the veterans treated in Veterans Affairs hospitals suffer from ... suicide than non-depressed veterans, University of Michigan researchers report. ... and might it be related to their use of ...
... conjunction with its fourth quarter 2008 earnings release (expected to be issued after ... is pleased to invite you to listen to its quarterly investor conference call ... at 9:00 a.m. ET., What: Covance Fourth ... Presentation, When: ...
... Outdoor Recreation Participation StudyFindings include increase in overall ... The Outdoor Foundation today announced the ... Report, the only detailed study of its ... The findings highlighted in the report are areas ...
... Club is hosting a,Pharmacy Challenge and Savings Checkup in ... check prices on their prescriptions and,over-the-counter medications against other ... on branded prescriptions. Membership is not,required to use ... "Your Healthy Year" promotes a variety of ways consumers ...
... FRANCISCO, Jan. 12 Within health care, dermatology,professionals play ... , The Dermatology Nurses, Association ... practice in a variety,of learning formats and the opportunity ... annual conference slated for March,4-7 at the Hilton San ...
... CYBX ) today announced that Milton ... Research and Development, effective on January 12, 2009. ... company,s development programs. Dr. Morris joins Cyberonics from ... company in North Carolina, where he has served ...
Cached Medicine News:Health News:With Depression, Vets Face Higher Suicide Risk 2Health News:With Depression, Vets Face Higher Suicide Risk 3Health News:As Childhood Obesity Rates Rise, Youth Outdoor Participation Declines 2Health News:As Childhood Obesity Rates Rise, Youth Outdoor Participation Declines 3Health News:Sam's Club(R) Hosts Pharmacy Challenge 2Health News:Hop the Trolley for DNA's 27th Annual Conference 2Health News:Cyberonics Names Milton M. Morris, Ph.D. Vice President, Research & Development 2Health News:Cyberonics Names Milton M. Morris, Ph.D. Vice President, Research & Development 3Health News:Cyberonics Names Milton M. Morris, Ph.D. Vice President, Research & Development 4
(Date:9/15/2014)... , Sept. 15, 2014 /PRNewswire-iReach/ -- MedicOne Medical Response, ... services, has been selected by Inc. Magazine as ... America. Photo - http://photos.prnewswire.com/prnh/20140914/145997 ... list identifies successful, privately-held companies with the largest ... Response, one of only two ambulance companies to ...
(Date:9/15/2014)... /PRNewswire-iReach/ -- CaPtivate Pharmaceuticals LLC, a ... (CaP)-based nanoparticle drug and vaccine delivery technologies, announced ... Agreement with Immunotope Inc., another Pennsylvania ... the treatment and prevention of viral infections and ... the agreement, Immunotope is granted a non-exclusive world-wide ...
(Date:9/15/2014)... The Society of Corporate Compliance and ... than 4,500 compliance and ethics professionals from across ... corporate fines and settlements.  The SCALENDAR is designed ... ready reference to demonstrate to employees the consequences ... to help compliance and ethics officers looking for ...
Breaking Medicine Technology:MedicOne Medical Response Named to 2014 Inc. 5000 Fastest Growing Companies List 2MedicOne Medical Response Named to 2014 Inc. 5000 Fastest Growing Companies List 3CaPtivate Pharmaceuticals Enters License Agreement With Immunotope 2CaPtivate Pharmaceuticals Enters License Agreement With Immunotope 3More than $55 billion in fines and settlements added by SCCE to its 2015 Corporate Scandal Calendar 2
... , WAYNE, N.J. and EMERYVILLE, Calif., Dec. ... Inc. (Nasdaq: ONXX ) today announced results ... 2 trials were presented at the 32nd Annual ... of these studies evaluated Nexavar® (sorafenib) tablets in ...
... , BATESVILLE, Ind., Dec. 11 Hill-Rom (NYSE: ... use in medical-surgical areas of hospitals and care facilities. The new bed ... to use a variety of care surfaces as needed. , "Hill-Rom ... the best features of Hill-Rom,s long-time leader, the Advanta bed, with many ...
Cached Medicine Technology:Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 2Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 3Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 4Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 5Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 6Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies 7Hill-Rom Introduces Innovative Smart Bed for Medical-Surgical Settings 2Hill-Rom Introduces Innovative Smart Bed for Medical-Surgical Settings 3Hill-Rom Introduces Innovative Smart Bed for Medical-Surgical Settings 4
Optipress II Automated Blood Component Extractor for the standardized separation of whole blood into high purity individual components...
The Eppendorf Maxipettor is a continuously adjustable pipette for precise pipetting of volumes up to 10 ml (in 10 l increments). Even liquids with a high vapor pressure or viscosity can be pipetted w...
eValuator fixed-curve diagnostic electrophysiology catheters offer an effective balance between clinical performance and cost....
... Two high performance technologies - Quantum™ ... shaft platform - unite in the ... a high dilatation force balloon with ... Laser bonded Maverick® shaft technology improves ...
Medicine Products: