Navigation Links
Acute Toxicity Of Nano-Scale Zinc Powder: Severe Renal Damage And Anemia

Zinc finds wide use in brass, bronze, die casting metal, alloys, rubber, and paints, etc. In recent years, nanoscale metal powders, because of their unique properties, are being widely used //in the traditional industries, such as dyes, paints, medical diagnosis, sunscreens and cosmetics. Nano Zn powder is used as highly reactive catalyst in organic hydrogen reaction, automobile tail gas disposal, environmental protection, paints, pigment, metallurgy additives.

Although zinc is an essential metal needed by mammals and commonly found in nutritional supplements, acute, high-dose oral exposure to zinc and its compounds generally results in gastrointestinal damage, with symptoms including nausea, vomiting, abdominal cramps, and diarrhea. According to the U.S. Department of Health and Human Services, 2003, ingesting high levels of zinc for several months may cause anemia, pancreas damage, and decrease the level of HDL- cholesterol.

Recently a study, to be published in Toxicology Letters, (available online 13 September 2005), was conducted in China to evaluate the acute toxicity of oral exposure to nanoscale zinc powder in mice.

The healthy adult male and female mice were gastrointestinally administered with two size particles, nanoscale zinc (N-Zn) and microscale zinc (M-Zn) powder, while one group mice treated with sodium carboxy methyl cellulose was used as the control.

The symptoms and mortality after zinc powder treatment were recorded. The effects of particles on the blood-element, the serum biochemical level and the blood coagulation were studied after 2 weeks of administration.

In the experiment, severe symptoms of lethargy, vomiting, and diarrhea were observed in the mice after an acute toxic dose oral administration of N-Zn powders. The N-Zn mice exhibit significant growth retardation compared with the M-Zn and the control mice in the first 3 days after treatment. Two deaths caused by the N-Zn administration indi cated that the N-Zn was probably easily causing intestinal obstruction than the M-Zn particles.

Since nanoscale particles have large specific surface area, it is found that their biological effects are mainly dependent on their surface area rather than particle mass. The authors concluded that N-Zn could induce heavy renal damage and anemia. However, they suggest that further research upon different exposure routes, especially inhalation exposure is required and long-term low level effect caused by nanoscale materials is now carried out in their laboratory.
'"/>




Related medicine news :

1. Acute Measles Supresses HIV Replication
2. Severe Acute respiratory Syndrome (SARS)
3. WHO Travel Advice to prevent spread of "Severe Acute Respiratory Syndrome (SARS)
4. Acute Pancreatitis On The Rise Due To Alcohol Consumption
5. Promised Drug Doesnt Help Acute Heart Failure
6. Gene Fusion Test to screen children’s with Acute Lymphoblastic Leukemi
7. Acute Gastroenteritis Responds To Treatment With Either Gatorade Or Pedialyte
8. Acute Shortage Of Neurosurgeons In India: One Surgeon For Every 1 Million!
9. Acute Shortage Of Dentists in UK: Oral Care for Elders To Suffer A Setback
10. Acute Lymphoblastic Leukemia May Attain a 90% Cure Rate
11. Women Health : Acute Stress, A Shot in The Arm For Flu?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... 12, 2017 , ... Vohra Chief Medical Officer Dr. Shark ... skilled nursing facility medical directors and other clinicians at various events in October. ... "At many of these conferences we get to educate other physicians, facility nurses, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... 2017   Montrium , an industry leader ... the IQPC Trial Master Files & Inspection Readiness ... EastHORN Clinical Services has selected eTMF Connect ... management. EastHORN, a leading European contract research organization ... transparency to enable greater collaboration with sponsors, improve ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
Breaking Medicine Technology: