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Active Lifestyle Reduces Risk of Invasive Breast Cancer

the first period, and tend to have irregular periods and a shortened estrogen-producing phase, which translates in a lower body exposure to estrogen, the researchers say.

Similarly, postmenopausal women who are physically active have also been shown to have lower levels of estrogen. This reduction may explain why increased physical activity reduces the risk of breast cancer, according to Amy Trentham-Dietz assistant professor at the University of Wisconsin-Madison and member of the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center. Other potential mechanisms include prevention of weight gain, regulation of insulin sensitivity and alterations in immune function.

Taking all these factors into consideration, "intervention studies assessing the effect of physical activity on estrogen and other hormone exposure, and other biomarkers of risk would provide valuable insights on the mechanisms of physical activity in reducing breast cancer risk," said Trentham-Dietz.

"Further studies of population subgroups are necessary to gain a better understanding of the relation of physical activity to breast cancer risk, and to identify the groups most likely to gain benefit from it," said Trentham-Dietz. "Future research should also consider household activity in addition to recreational and occupational activities."

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