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Acrolein may be the key to halting spinal cord damage

unter acrolein's effects could join the other approaches to treating spinal cord injury under development at Purdue’s Center for Paralysis Research.

"My colleague Richard Borgens and I have already had our hands in developing PEG, a substance that coats damaged spinal cells so that their membranes can heal and also oscillating field stimulator implants that encourage the tissue to regenerate," Shi said. "We are hopeful that detoxifying acrolein will allow doctors to stop the chemical attack cycle as well, adding to the number of treatment methods available."

The center was established in 1987 both to develop and to test promising methods of treatment for spinal cord injuries. The center uses its close affiliation with the Department of Veterinary Clinical Sciences in the College of Veterinary Medicine to move basic laboratory methods into clinically meaningful veterinary testing.

This research was funded in part by the National Institutes of Health and the State of Indiana.

Writer: Chad Boutin, (765) 494-2081, cboutin@purdue.edu

Source: Riyi Shi, (765) 496-3018, riyi@purdue.edu

Purdue News Service: (765) 494-2096; purduenews@urdue.edu
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