Navigation Links
Abnormalities in Eye Movements and Attention can Predict Schizophrenia

A Binghamton University researcher has established a new framework to help determine whether individuals might be at risk// for schizophrenia.

In a study published in this month’s Journal of Abnormal Psychology, Mark F. Lenzenweger, a professor of clinical science, neuroscience and cognitive psychology at Binghamton University, State University of New York (SUNY), is the first to have found that abnormalities in eye movements and attention can be used to divide people into two groups in relation to schizophrenia-related risk.

“Schizophrenia affects one in every 100 people,” said Lenzenweger, who considers it the costliest form of mental illness known to humankind. It has a strong genetic component; about 80 percent of what determines schizophrenia is related to genetic influences.

“Not only does it impair people’s cognitive, emotional, social and occupational functioning when it’s going in full symptomatic form,” he said, “it stays with people across the lifespan. Schizophrenia starts early in life, beginning anywhere from 15 to 30, and continues onward. What you have is a person who is impaired, has been removed from the workforce, as well as requires lifelong care and there are immense costs attached to their illness.”

According to Lezenweger, prior studies started with someone who had the illness and then backtracked to find deficits, such as eye tracking and sustained attention problems.

“What I said we needed to do was to go into the general population and measure those traits – those neurocognitive processes – and see whether impairment in those processes predicts schizotypic features. So I really turned the whole question on its head,” said Lezenweger.

The study, funded by a $100,000 Distinguished Investigator Award from the National Alliance for Research on Schizophrenia and Depression, or NARSAD, involved 300 adults drawn from the general population. The findings suggests that the manne r in which the eyes can follow a target and how well one can pay attention to a task together help to pinpoint risk factors related to schizophrenia.

“I was able to integrate several threads of work that I had been developing over the prior 15 or 20 years,” he said. “I proposed the study in a way that tied together several methodological and theoretical threads in the way I would want to do it ideally, and they supported it. It was a high-risk funding decision, and I am grateful to NARSAD for getting behind the study.”

Lenzenweger collaborated with Geoff McLachlan at the University of Queensland in Australia and Donald B. Rubin of Harvard University, both leaders in the application of new statistical methods to health-related problems. They applied a technique called finite mixture modeling to separate the research subjects into the two groups.

For years, debate in the field has centered on whether risk for schizophrenia was graded or more binary in nature. Lenzenweger and his colleagues showed that people could be divided into two groups, those at risk and those not at risk.

In the new study, the smaller of the two groups contained individuals who displayed dilute forms of schizophrenia-like symptoms even though they had never had the illness. Study of these people revealed actual schizophrenia in their biological family members, but not other psychiatric illnesses.

“What was very exciting for us is that this method allows you to assign a probability to every person in the sample with respect to likelihood of risk for schizophrenia liability,” Lenzenweger said. “By doing this, one can generate very precise estimates of where individuals fall on the risk dimension.”

A second, mathematically independent model called taxometric analysis generated the same clean partitioning of the two groups, Lenzenweger noted.

Although the risk predictions can be made now, they are not yet ready for c linical applications by practicing therapists. Lenzenweger envisions using the new model as a way to choose schizotypic individuals – people who are at risk for the illness but do not have it – for more intense genomic study. That sort of research may help scientists pinpoint the gene or genes that cause schizophrenia.

“The study of schizotypic individuals offers a unique perspective on what might cause the illness,” Lenzenweger explained. “It provides a clearer window on the likely underpinnings of the illness prior to the devastating impact of the clinical illness.
Source-Newswise
SRM
'"/>




Related medicine news :

1. Early Detection Of Facial Abnormalities in a Fetus
2. Detecting Brain Abnormalities in Babies Using New Brain Scanners.
3. Brain Abnormalities Raise the Risk of PTSD
4. Medication Abuse In Chronic Migraine May Cause Hormonal Abnormalities
5. Pre Mature Babies Face the Risk Developmental Abnormalities
6. Seroxat Heart Abnormalities Risk Doubted
7. Structural Abnormalities in Brains of William Syndrome Patients
8. Blocking Glucocorticoid Prevents Stress-Induced Skin Abnormalities
9. Girls Born With HIV Infection at Higher Risk for Cervical Abnormalities
10. Brain Controlled Movements Are Studied Using Robotic- Joystick
11. The Best Way To Get Your Childs Attention
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... ... ... Louisans are well-aware of the following facts at present:, Flu ... having no effect on keeping this particularly bad strain of the flu away , ... or sniffling , These facts are well-known among the team at Woodard! ...
(Date:1/16/2017)... , ... January 16, 2017 , ... ... to provide first-quality education and high-level training standards to an international multidisciplinary group ... eating disorder problems. As a way to further its mission at the grassroots ...
(Date:1/16/2017)... ... 16, 2017 , ... Vixiar Medical, Inc. announced ... device company, effective immediately. , “This is perfect timing for Kevin to come ... record in medical device market development and revenue growth, particularly in building new ...
(Date:1/15/2017)... (PRWEB) , ... January 15, 2017 , ... ... Gensuite’s Community Outreach is a program that strives to better communities around the ... global locations’ community. It also provides the opportunity for team members to become ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... PUNE, India , January 16, 2017 ... titled, "Vital Signs Monitoring Devices Market by Type and End ... the global vital signs monitoring devices market size was worth ... million by 2022, growing at a CAGR of 5.8% from ... the leading regional market in global vital signs monitoring devices ...
(Date:1/16/2017)... and PUNE, India , January ... new report published by Allied Market Research, titled, "Sterilization ... Analysis and Industry Forecast, 2014-2022," the global sterilization technologies ... from $5,768 million in 2015, growing at a CAGR ... gas sterilization segment dominated the market in 2015, with ...
(Date:1/16/2017)... PORTLAND, Oregon and PUNE, India , January 16, ... Market Research, titled, "Antioxidants Market by Type - Global Opportunity Analysis and Industry ... and is expected to reach $4,531 million by 2022, registering a CAGR of ... accounted for more than one-third share of the global volume in 2015. ... ...
Breaking Medicine Technology: