( A New diagnosis method to monitor the p...)Abnormal Abeta - Protein Level in Human Brain Trigger Alzheimer's Risk,Health

A New diagnosis method to monitor the production and clearance rates of amyloid beta peptide (Abeta) proved beneficial in tracking human brain disorders. //

Amyloid Beta Peptide (Abeta) protein levels in the central nervous system of humans can now be possibly diagnosed with the new monitoring method developed by the researchers at Washington University School of Medicine in St. Louis.

Media assistance: Michael Purdy (314) 286-0122 Science is now poised to answer an important and longstanding question about the origins of Alzheimer's disease: Do Alzheimer's patients have high levels of a brain protein because they make too much of it or because they can't clear it from their brains quickly enough?

Researchers from the Alzheimer's Disease Research Center (ADRC) at Washington University School of Medicine in St. Louis have developed the first safe and sensitive way to monitor the production and clearance rates of amyloid beta peptide (Abeta) in the human central nervous system. According to the authors, the new testing process opens a valuable window into the genesis of Alzheimer's disease that, in addition to helping scientists better understand the origins of the condition, will likely help them improve its diagnosis and treatment.

The scientists' results will be published online on June 25 by Nature Medicine.

High levels of Abeta in the brain are a hallmark of Alzheimer's disease and believed to be a pivotal cause of the condition. Tests that measure Abeta levels in the cerebrospinal fluid have been available for some time. However, those fixed assessments of Abeta gave no indication of whether the flood of Abeta in patient's brains came from an increase in the mechanisms that make the protein or a reduction in the processes that regularly clear it from the brain.

Because Alzheimer's symptoms take many years to develop, some researchers had assumed that the creation and clearance rates for Abeta were v
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