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ABCB6 Is Key to Production of Heme in Hemoglobin

e cell by altering levels of heme or porphyrins,' Schuetz said.

Armed with this new information, researchers will be better able to study certain diseases at the molecular level and learn more about their causes and perhaps how to prevent or treat them. One such group of diseases is cutaneous porphyria, a buildup of porphyrins that causes the skin to blister and swell in sunlight; and acute porphoryia, a nerve problem that triggers pain in the chest, abdomen, limbs or back, as well as paralysis, cramping and personality changes or mental disorders. 'Also, people with porphyria can suffer sudden, acute attacks if they take certain tranquilizers and other drugs that interfere with this system,' Schuetz said. 'So our work contributes to the overall picture of how disruption of the biochemical pathway of heme production can cause a variety of serious diseases.'

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