( onsequence of experiments in test tubes...)A question on study of Adult Stem Cell,Health

onsequence of experiments in test tubes and animal models -- but we need to carefully examine the complete identity of the resulting cell types."

"Practically speaking, what these findings do is send those researchers who have claimed great multipotentiality for adult stem cells back to the lab, to test whether the 'transdifferentiation' they have observed is actually due to cell fusion," Lander said. "Now that they have been made aware of what to look for, it should not take too long before such researchers make the necessary observations to resolve this question."

While the studies showed cell fusion in a petri dish is possible, "that's a long way from showing that fused cells happen often, or that they are responsible for the findings of others in which adult stem cells seemed to show multipotency," Lander told UPI. "If indeed that's the only way such adult stem cells become multipotent, then one would indeed have to be concerned that such cells are clearly not 'normal' in the sense of having too many chromosomes. Such abnormality could be totally benign, or it could cause health problems, e.g. susceptibility to cancer; we just don't know."

"This discovery of fusion in a dish is simply another issue in our evolving understanding of stem cell behavior that needs to be considered, examined and evaluated in multiple experimental systems to see whether is it relevant to (animal) biology or a tissue culture phenomenon," Mark Sussman of the Division of Molecular Cardiovascular Biology at The Children's Hospital and Research Foundation in Cincinnati, Ohio, told UPI. "The potential still exists for stem cells -- even hybrid ones -- to have relevant biological activity and provide (medical) benefit."


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