Navigation Links
A question on study of Adult Stem Cell

Two studies may form a tiresome feeling over visions of adult stem cells as a less honestly questionable but nearly equally versatile alternative to embryonic stem cells, whose ability to sprout different cell types has spawned debate between those who think such research destroys a life and those who say it has life-saving potential. The new findings challenge the notion adult stem cells taken from one tissue can directly produce cell types of other tissues and organs.// It may be that this capability, revealed in recent research, may arise from a process of fusion that combines two cells into one, and not from one cell changing into another type. Scientists said that such hybrids have double the normal DNA and possibly carry unknown health consequences.

Researchers feel that, whether the process, observed in mouse brain cells in laboratory experiments, also occurs in animals, including humans, remains to be seen. "This suggests a need for caution with regard to the therapeutic use of adult tissue stem cells. If they only make other tissues by fusing with existing cells rather than producing new cells, their utility for tissue repair and regenerative medicine will be greatly restricted," said Austin Smith of the University of Edinburgh in England, lead author of one of the papers.

"While there is justifiably a great deal of interest in the broader applicability of adult stem cells, our findings illustrate that we are currently very ignorant of their biology," Smith said. "It should be noted that although spontaneous cell fusion has been well documented and this work has been overlooked in the recent reports on tissue stem cells."

Studies have shown adult stem cells from one tissue, such as blood, can generate numerous other cell types, such as nerve and muscle, in a fashion reminiscent of embryonic stem cells but without the ethical concerns. These findings -- which the Nature papers now question -- have challenged the traditional v iew that with the possible exception of those from the brain, adult stem cells are limited to the tissues from which they arise. Many opponents of the creation of stem cells through the removal of an inner cell mass from a 5-to-7-day-old embryo, which is killed in the process, have pointed to adult stem cell research as a viable, less morally offensive alternative to stem cells extracted from embryos. Still in a blank state, embryonic stem cells can turn into any of the cell types in the body.

This morphing power has inspired visions of stem cells one day being used to grow new heart, liver or brain tissue for people whose own organs are damaged, allowing the body to repair itself. Realization of such potential is many years down the road, if ever, scientists cautioned. "There are those who have been expecting a 'quick fix' with stem cells, and these folks will indeed get somewhat of a reality check from these findings," Dr. Arthur Lander, professor and chairman of developmental and cell biology at the University of California, Irvine, told UPI.

The findings -- in separate studies by Smith and team and Naohiro Terada of the University of Florida in Gainesville -- point to an occurrence the previous experiments failed to expose. Adult cells from either the bone marrow or the brain grown in the same dish as embryonic stem cells joined to make hybrid cells able to produce muscle, nerve and other cell types. Studies will be required to confirm that such spontaneous cell fusion between donor and host cells can also take place in animals.

"We decided to publish our rather disappointing discovery about the fusion of stem cells in order to provide very important caution to all scientists now working in this promising area of research," Terada told UPI. "We want the scientific community to know that it is not just important to determine the fact that certain types of stem cells have successfully turned into other types of stem cells -- as a c onsequence of experiments in test tubes and animal models -- but we need to carefully examine the complete identity of the resulting cell types."

"Practically speaking, what these findings do is send those researchers who have claimed great multipotentiality for adult stem cells back to the lab, to test whether the 'transdifferentiation' they have observed is actually due to cell fusion," Lander said. "Now that they have been made aware of what to look for, it should not take too long before such researchers make the necessary observations to resolve this question."

While the studies showed cell fusion in a petri dish is possible, "that's a long way from showing that fused cells happen often, or that they are responsible for the findings of others in which adult stem cells seemed to show multipotency," Lander told UPI. "If indeed that's the only way such adult stem cells become multipotent, then one would indeed have to be concerned that such cells are clearly not 'normal' in the sense of having too many chromosomes. Such abnormality could be totally benign, or it could cause health problems, e.g. susceptibility to cancer; we just don't know."

"This discovery of fusion in a dish is simply another issue in our evolving understanding of stem cell behavior that needs to be considered, examined and evaluated in multiple experimental systems to see whether is it relevant to (animal) biology or a tissue culture phenomenon," Mark Sussman of the Division of Molecular Cardiovascular Biology at The Children's Hospital and Research Foundation in Cincinnati, Ohio, told UPI. "The potential still exists for stem cells -- even hybrid ones -- to have relevant biological activity and provide (medical) benefit."


'"/>




Related medicine news :

1. Use of CT scans to detect lung cancer questioned
2. New study questions consumption of milk for bone growth
3. Terri Schiavo is no more, but the question of Mercy killing is unresolved…
4. New study questions consumption of milk for bone growth
5. The question of who is the actual father
6. Scotland faces shortage of dentists questioning the dental facilities
7. New protein diet program questioned.
8. Glycaemic Index as an index of diet and tool questioned
9. Green tea’s health claims questioned: FD
10. A new study surpasses Gene Therapy Hurdle
11. Marijuana gateway theory strengthened by study of twins
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2017)... ... 24, 2017 , ... The weather is heating up and the days are ... should be aware that the summer months provide more than warmer temperatures that are ... can be negatively affected from direct exposure to the sun. When it comes to ...
(Date:6/23/2017)... , ... June 23, 2017 , ... By scoring 100% ... ninth consecutive four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's work ... 1% of all charities reviewed by Charity Navigator and earns ANRF a spot on ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... plastic surgeon practicing in Newburgh, New York, has recently begun offering three new ... to offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited ...
(Date:6/23/2017)... Hills, CA (PRWEB) , ... June 23, 2017 , ... ... plane facelift . Dr. Talei has come up with a proprietary technique that ... releases and lifts tissues that have dropped. For all ages, patients can expect to ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... MD ... Florida. This is MD Now’s 28th facility overall and marks the urgent care center's ... located one mile North of The Falls shopping mall. The new clinic offers a ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal ... July 28, 2017, beginning at 7:30 a.m. (CDT) / 8:30 ... To participate in the conference call, dial (877) 304-8969 (domestic) ... least 10 minutes prior to the start to allow time ... Webcast: A simultaneous webcast of the ...
(Date:6/16/2017)... , June 16, 2017  Exactly 50 years ago ... off what later became known as the San Francisco "Summer ... ) is unveiling two radical innovations in strategic market research ... This announcement marks the beginning of Northern Light,s "Summer of ... ...
(Date:6/14/2017)... -- In 2016, Embodied Labs took top prize ... came away with $25,000 in seed-fund investment. Embodied Labs ... "entering the life of another" and by the Journal ... medical professionals in an entirely new dimension." Building upon ... for the Department of Education,s EdSimChallenge, where they received ...
Breaking Medicine Technology: