Navigation Links
A new recovery for heart attacks,,

Researchers form Australia have correlated a molecular 'switch' that helps our body's cells make up when oxygen levels fall, a finding that could provide the basis for future drugs to help in recovery from stroke and heart attack. //

A team from the University of Adelaide's Molecular Biosciences department and CSIRO Health Sciences and Nutrition report their findings in this week's issue of Science.It is known that certain genes are energized in low-oxygen conditions. These genes help increase delivery of oxygen by making more red blood cells and blood vessels. They also reduce the body's reliance on oxygen by switching to a form of energy production not dependent on oxygen, called glycolysis (which uses glycogen from the liver).

Previous research has found that a protein known as Hypoxia Inducible Factor (HIF) responds to low oxygen levels and switches on the genes. However, the nuts and bolts of how it does that have to date only been partially understood.HIF was identified as having two segments that were involved in the switching process. One segment had been found to be reliable for increasing the amount of HIF in the cell. Under normal circumstances HIF is constantly made and broken down. However researchers have found that under low-oxygen levels, HIF loses a hydroxyl (oxygen and hydrogen) group from a proline amino acid on this domain. This changes the shape of the protein and makes it less likely to be degraded.

The other domain of HIF was known to be responsible for the actual activation of genes that helped cells adapt to low oxygen, however the molecular switch for that has to date been unknown.Dr Whitelaw and colleagues found under low-oxygen levels, HIF loses a hydroxyl molecule from an asparagine amino acid on this other domain. This changes the shape of the protein and allows it to activate the genes.

"The finding has implications for treating heart diseases in which tissues are deprived of oxygen because th e blood vessels are not functioning correctly," Dr Whitelaw said.He said his findings could be used to help develop drugs that enhance cells' adaptation to low-oxygen conditions. These drugs would prevent the binding of hydroxyl groups to the HIF protein and in turn boost the amount of the protein around to improve oxygen delivery.

The researchers have patented the asparagine-hydroxyl part of the HIF protein as a possible target for drugs, and will now look for other oxygen-controlled proteins that could be involved in the body's response to low oxygen levels.


'"/>




Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Frozen Canadian baby stages miraculous recovery
3. New point scale to ascertain the stroke recovery
4. New Drug, Pleconaril speeds recovery from common cold
5. Use of Statin can help in recovery from stroke
6. Making operation and recovery time shorter
7. Lessening operation and recovery time
8. An unlikely contender for speedy surgery recovery: Chewing gum
9. Television soaps showing unrealistic coma survival and recovery
10. Starvation in pregnant women can cause heart disease to their children
11. Individuals with sleep related breathing disorders more prone to heart disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris ... of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking ... in the field of medical informatics, this prestigious award is presented to an individual ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... Sept. 12, 2017   EcoVadis , the leading platform for environmental, ... first annual edition of its Global CSR Risk and Performance Index. The ... EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points across ... ... ...
Breaking Medicine Technology: