Navigation Links
A new recovery for heart attacks,,

Researchers form Australia have correlated a molecular 'switch' that helps our body's cells make up when oxygen levels fall, a finding that could provide the basis for future drugs to help in recovery from stroke and heart attack. //

A team from the University of Adelaide's Molecular Biosciences department and CSIRO Health Sciences and Nutrition report their findings in this week's issue of Science.It is known that certain genes are energized in low-oxygen conditions. These genes help increase delivery of oxygen by making more red blood cells and blood vessels. They also reduce the body's reliance on oxygen by switching to a form of energy production not dependent on oxygen, called glycolysis (which uses glycogen from the liver).

Previous research has found that a protein known as Hypoxia Inducible Factor (HIF) responds to low oxygen levels and switches on the genes. However, the nuts and bolts of how it does that have to date only been partially understood.HIF was identified as having two segments that were involved in the switching process. One segment had been found to be reliable for increasing the amount of HIF in the cell. Under normal circumstances HIF is constantly made and broken down. However researchers have found that under low-oxygen levels, HIF loses a hydroxyl (oxygen and hydrogen) group from a proline amino acid on this domain. This changes the shape of the protein and makes it less likely to be degraded.

The other domain of HIF was known to be responsible for the actual activation of genes that helped cells adapt to low oxygen, however the molecular switch for that has to date been unknown.Dr Whitelaw and colleagues found under low-oxygen levels, HIF loses a hydroxyl molecule from an asparagine amino acid on this other domain. This changes the shape of the protein and allows it to activate the genes.

"The finding has implications for treating heart diseases in which tissues are deprived of oxygen because th e blood vessels are not functioning correctly," Dr Whitelaw said.He said his findings could be used to help develop drugs that enhance cells' adaptation to low-oxygen conditions. These drugs would prevent the binding of hydroxyl groups to the HIF protein and in turn boost the amount of the protein around to improve oxygen delivery.

The researchers have patented the asparagine-hydroxyl part of the HIF protein as a possible target for drugs, and will now look for other oxygen-controlled proteins that could be involved in the body's response to low oxygen levels.


'"/>




Related medicine news :

1. Thyroid hormone treatment hastens recovery after cardiac surgery
2. Frozen Canadian baby stages miraculous recovery
3. New point scale to ascertain the stroke recovery
4. New Drug, Pleconaril speeds recovery from common cold
5. Use of Statin can help in recovery from stroke
6. Making operation and recovery time shorter
7. Lessening operation and recovery time
8. An unlikely contender for speedy surgery recovery: Chewing gum
9. Television soaps showing unrealistic coma survival and recovery
10. Starvation in pregnant women can cause heart disease to their children
11. Individuals with sleep related breathing disorders more prone to heart disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... ... February 10, 2016 , ... LaserShip, a regional parcel carrier that services ... of Eastern Michigan last Friday in order to aid in the Flint water crisis. ... include a facility located in Clio, only 15 miles away from Flint. , “We ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... (VRI) within Healthcare, recently partnered with Heart City Health Center to ... nearly 23 years, Heart City Health Center has provided the Elkhart community with ...
(Date:2/10/2016)... ... 2016 , ... 10 Best Water is excited to announce a ... owners that topped the list as a result of their commitment to offering clients ... was Tibet 5100, a top notch water company that specializes in providing the public ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... organization, welcomes S.S. Nesbitt as the latest addition to its growing list of ... other locations throughout the Southeast, from Orlando to Huntsville and in between. , ...
(Date:2/10/2016)... ... February 10, 2016 , ... Pediatric therapists are challenged ... Research shows that the Goal Attainment Scale (GAS) captures 20% more change in ... learn more about the Goal Attainment Scale, Education Resources Inc. is offering a ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)...  Fotona, based in the U.S. and Europe ... PRO Lightwalker dental laser at the upcoming 151 st ... 2016 in booth #4815. The ST PRO is a full ... the features of the award winning, industry leading Lightwalker ATS. At ... will be very attractive to many dentists hesitating to incorporate ...
(Date:2/10/2016)... Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ... fourth quarter and full year ended December 31, 2015. ... was a transformational year for Vanda with the continued ... market approval of HETLIOZ for Non-24," said Mihael H. ... Fanapt to our U.S. product portfolio builds on this ...
(Date:2/10/2016)... A new report from business intelligence provider GBI Research ... Alzheimer,s disease market will more than double from just under $5 billion in ... Rate (CAGR) of 11%. Canada , France ... Spain , the UK, and Japan , and ... --> Canada , France , ...
Breaking Medicine Technology: