Navigation Links
A high BMI may not determine obesity, researchers say

Body mass index (BMI), which is the ratio of height and weight, has been in use to depict the clinical weight of patients. A lower BMI is associated with a lesser weight// and a leaner person as against a high BMI, which is associated with obesity and its allied health risks.

But the BMI has come under scrutiny lately, and other techniques that measure how the weight is distributed on the body are thought to provide a better way to assess risk. Now a study in mice by scientists at The Jackson Laboratory indicates that the usefulness of the BMI is suspect even at the genetic level.

In research published in PLoS Genetics, the investigators from Jackson and the J.L. Pettis VA Medical Center and led by Dr. Gary Churchill of Jackson used a combination of computational, molecular and genetic tools to identify locations on the mouse genome that influence adiposity (amount of body fat), overall body size and bone structure. Applying an analytical technique called "structural equation modeling" to the genetic and physical characteristics of mouse inbred crosses, the scientists went beyond the one-gene, one-trait approach to reveal the networks of effects created by the influence of multiple genes.

"We found that the genetic network affecting adiposity is separate from that affecting overall body size," Churchill says, "providing strong evidence that a high weight is not necessarily directly associated with a high percentage of fat."

At the clinical level, the research suggests that more refined measurements are needed to distinguish individuals with a large body mass from those who are truly obese and consequently at high risk for diabetes, heart disease and other disorders.

Churchill and colleagues at Jackson recently received a 5-year, $15.1 million National Institute of General Medical Sciences grant to form an interdisciplinary Center for Genome Dynamics to study complex biomedical problems. "The most comm on diseases and health disorders, including obesity as well as heart disease, diabetes and cancer, result from an interaction of multiple genes and environmental factors that add up to a dauntingly complex mix of variables," Churchill says. "We're working to unravel those factors to lay the groundwork for improved treatments."

Source : Eureka Alert


'"/>




Related medicine news :

1. Breast cancer treatment to be determined by gene test
2. How to determine allergies?
3. Hormone regimen and how recently used may determine cancer risk
4. Watch out those of you planning for a predetermined Cesarean Section
5. Age of first alcoholic drink determined by tendency to cheat
6. Viscosity of Women cervix determines sex of child
7. HIV Type determines turn-out of the disease.
8. Crucial to regulate your body pH, key determiner for good health
9. Gene determines pain threshold...
10. Genes determine the capacity to fight HIV in early stages
11. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2017)... , ... January 24, 2017 , ... Bellus Medical, a ... team of medical experts. In his new role Dr. Dobke will provide physician oversight ... Dr. Dobke is the Head of Plastic Surgery and Associate Professor of Surgery at ...
(Date:1/24/2017)... Iowa City, IA (PRWEB) , ... January 24, 2017 , ... ... in the country, has taken great care to design a program that provides teachers ... language abroad and domestically. This online teaching certificate is ideal for post-baccalaureate students and ...
(Date:1/24/2017)... Pass, OR (PRWEB) , ... January 24, 2017 ... ... Gerald H. Pollack, Ph.D., http://www.faculty.washington.edu/ghp , Sharon Kleyne, the nation’s foremost ... of Water, Global Climate Change and Your Health on Voice America, once again ...
(Date:1/24/2017)... ... January 24, 2017 , ... TopConsumerReviews.com ... for relieving premenstrual syndrome, or PMS . , Most women of child-bearing ... can include cramps, constipation, irritability, headaches, fatigue, and other discomfort. For some ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Spiritual Vitamins: A ... connection with God. “Spiritual Vitamins: A Spiritual Energy Booster” is the creation of ... Publishing, Mathai Yohannan’s new book engages the mind and spirit in a quest ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... 2017 Sherpa Clinical Packaging ( www.sherpaclinical.com ... is pleased to announce the appointment of Kevin Rosenthal as ... Sherpa team to lead Sherpa,s Operations group and ... excellence. Kevin is not new to ... He has extensive experience working for leading pharma ...
(Date:1/24/2017)... YORK , January 24, 2017 ... the fastest growing industries in the United States ... medicinal use in 2016. In addition, Proposition 64, the California ... for and 42.87% against on November 8, 2016. This outcome ... allowed to use and to grow a certain amount of ...
(Date:1/24/2017)... 24, 2017   Keneric Healthcare , a ... effective patient care products, today announced their partnership ... the reach of both companies by leveraging their ... Angelini Pharma Inc . ... include Keneric Healthcare,s RTD™ Wound Dressing (antibacterial/antifungal).  RTD™ ...
Breaking Medicine Technology: