Navigation Links
A gene related to aggression weakens the brain

National Institutes of Health's (NIH) National Institute of Mental Health (NIMH) researchers have found out that gene previously linked to impulsive violence appears// to weaken brain circuits that regulate impulses, emotional memory and thinking in humans.

It was studied through brain scans that revealed that people with this version of gene – especially males – tended to have relatively smaller emotion-related brain structures, a hyperactive alarm center and under-active impulse control circuitry.

This was reported by NIMH intramural researchers Andreas Meyer-Lindenberg, M.D., Daniel Weinberger, M.D., Ph.D., and colleagues in the Proceedings of the National Academy of Sciences during the week of March 20, 2006.

According to NIH Director Elias A. Zerhouni, M.D., who conducted MRI studies earlier in his career said, "These new findings illustrate the breathtaking power of 'imaging genomics' to study the brain's workings in a way that helps us to understand the circuitry underlying diversity in human temperament. By itself, this gene is likely to contribute only a small amount of risk in interaction with other genetic and psychosocial influences; it won't make people violent. But by studying its effects in a large sample of normal people, we were able to see how this gene variant biases the brain toward impulsive, aggressive behaviour."

The gene is one of two common versions that code for the enzyme monoamine oxydase-A (MAO-A), which breaks down key mood-regulating chemical messengers, most notably serotonin.

Structural MRI in 97 subjects was taken for the study and the results were that those with L showed reductions in gray matter (neurons and their connections) of about 8 percent in brain structures of a mood-regulating circuit (cingulate cortex, amygdala) among other areas. Volume of an area important for motivation and impulse regulation (orbital frontal cortex) was increased by 14 percent in men only. Altho ugh the reasons are unknown, this could reflect deficient pruning – the withering of unused neuronal connections as the brain matures and becomes more efficient, speculates Meyer-Lindenberg.

The researchers then looked at effects on brain activity using functional MRI (fMRI) scans. While performing a task matching emotionally evocative pictures – angry and fearful faces – subjects with L showed higher activity in the fear hub (amygdala). At the same time, decreased activity was observed in higher brain areas that regulate the fear hub (cingulate, orbital frontal, and insular cortices) – essentially the same circuit that was changed in volume.

Daniel Weinberger, M.D., Ph.D. said, "Heightened sensitivity in brain circuits important to cognitive inhibition and memory for negative emotional information may contribute to increased vulnerability of men with L exposed to abuse during childhood. Since only men showed gene effects in several of these circuits, this could lead to a situation where multiple brain control mechanisms are impaired and contribute to manifestly violent behavior, a kind of genetic double jeopardy."
br>
'"/>




Related medicine news :

1. Heart disease in the newborn is related to maternal malnutrition
2. Individuals with sleep related breathing disorders more prone to heart disease
3. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
4. Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
5. Dampness related to asthma
6. Allergies are related to mothers menses
7. Genetic disorder related with sleep patterns
8. Energy intake directly related to portion size
9. Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
10. New Drug Shows Significant Improvement In HIV-related Heart Condition
11. Sleeping Less May be related to Weight Gain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... February 24, 2017 , ... The Smart Machine Age ... Oxford University predict that 47 percent of all jobs in the United States may ... and “successful.” The day of the aggressive know-it-all who steamrolls over colleagues is drawing ...
(Date:2/24/2017)... Texas (PRWEB) , ... February 24, 2017 , ... ... to The Medical Center at Craig Ranch building at 8080 State Highway 121, Suite ... Medical District with easy access to Highway 121. , As the practice has grown, ...
(Date:2/24/2017)... ... , ... The California State University Institute for Palliative Care is ... in palliative care education and research. The Symposium, “Innovate. Investigate. Educate: Advancing Academic ... on Sept. 28 and 29, 2017, on the campus of California State University San ...
(Date:2/24/2017)... ... ... Indiana Fiber Network (IFN) President and CEO Kelly C. Dyer recently announced that he ... of the Management Committee when IFN was originally formed in 2002 where he was ... development of the business plan. He became the first paid employee of IFN ...
(Date:2/24/2017)... CA (PRWEB) , ... February 24, 2017 , ... ... for qualifying into the Senior International Elite division on February 12th. Ms. ... Around divisions at the elite qualifier competition held in Las Vegas, Nevada. Frida ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 23, 2017  Directors from Pharma To Market Pty Ltd and ... forces, resulting in the founding of Pharma To Market Pte Ltd, ... Market are pleased to announce their expansion into Asia ... Singapore . The company are delighted to appoint Joelle ... Singapore based entity. Joelle brings with her ...
(Date:2/24/2017)... YORK , Feb. 23, 2017  The ... 330.6 million by 2021 from USD 275.9 million ... Read the full report: http://www.reportlinker.com/p04718602-summary/view-report.html ... increasing spending on pharmaceutical R&D, and growth in ... driving the market growth for particle counters. On ...
(Date:2/24/2017)... Feb 24, 2017 Research and Markets has ... and Strategies - 2016" report to their offering. ... The latest research Urinary ... data and benchmarks in the global Urinary Incontinence market. The ... are the key drugs marketed for Urinary Incontinence and their clinical ...
Breaking Medicine Technology: