( tient's lifespan beyond the 12-month tr...)A cost effective heart failure drug hits the market!,Health

tient's lifespan beyond the 12-month trial period. Even under the most pessimistic assumption that, over time, the drug would no longer provide therapeutic benefits the model predicted that for 95 percent of patients, health care costs would still amount to less than what is considered to be a reasonable threshold for cost-effectiveness.

As another statement by Dr.Angus clarifies, "Using very conservative restrictions, our model suggests that this drug, even if used for lifetime courses over many years, should be very cost-effective. The key will be appropriate patient selection and careful attention to compliance with treatment. Our findings apply to the types of individuals, African-Americans with moderate to severe heart failure, who were enrolled in AHeFT. We do not know whether similar benefits would be found in other groups of patients."

"Because we relied on the actual data regarding health care resource use, our primary findings are likely to be very robust, as robust as the overall clinical trial results from AHeFT," said Dr. Angus.

A-HeFT involved 1,050 African-American patients at 11 sites with New York Heart Association Class III or Class IV failure, which is defined as moderate to severe heart failure resulting in significant limitations to physical activity. AHeFT participants were randomly assigned to receive ISDN/HYD or a placebo in addition to their regular heart failure therapy. The patients' age averaged 56.8 years, and 40 percent of the patients were women. The patients were followed for an average of 12.8 months, and the study ended prematurely when a preliminary analysis showed that patients treated with ISDN/HYD had a significantly lower mortality 6.2 percent compared to 10.2 percent.

This study was aimed at the African –American community only.
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