Navigation Links
A Study Finds VENs Devastated in FTD

The official journal of the American Neurological Association, examined brain tissue acquired at autopsy and found that VENs were devastated in FTD//.

Von Economo neurons (VENs) are uniquely shaped brain cells that seem to have evolved in a select group of socially complex species: great apes, humans, and, as reported last month, whales. Across species, VENs are localized to frontal brain regions associated with cognition, emotion and social behavior. Frontotemporal dementia (FTD), a common neurodegenerative condition, is characterized by early breakdown in social and emotional awareness and is accompanied by atrophy and dysfunction in the brain areas where VENs are located. A new study published in the December 2006 issue of Annals of Neurology.

Led by William W. Seeley, M.D., of the Department of Neurology at the University of California, San Francisco, researchers quantified anterior cingulate cortex VENs in seven patients with FTD, five with Alzheimer’s disease (AD), and seven control subjects who were not demented. All FTD patients had prominent changes in social behavior and emotion, sometimes accompanied by deficits in cognitive function.

In contrast, AD patients had an array of cognitive symptoms, including memory and language impairment, with little change in social behavior. The researchers found early, severe, and selective loss of VENs in FTD, which showed a 69% reduction compared to AD and controls after controlling for overall neuronal loss.

"Our findings suggest that selective VEN loss is a defining feature of FTD but does not apply to AD," the researchers state, adding that future research should explore how VEN loss relates to specific social/behavioral deficits in FTD and other disorders where such deficits are a defining feature.

VENs receive chemical signals from dopamine, serotonin, and vasopressin systems that play important roles in social and emotional bonding. These functions are disrupt ed early in FTD but spared in AD, the authors note. While drugs aimed at preserving VEN function may help curtail FTD symptoms, basic studies of VEN biophysical and molecular properties are needed to clarify the mechanisms that cause VENs to degenerate in FTD.

"Distinctive functions of these unique cells may prove invaluable in health, yet may also expose us to specific forms of developmental or later-life illness," the authors conclude. "The link forged here between VENs and FTD should spawn further studies of how human brain evolution relates to human brain disease."

Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/22/2017)... ST. PAUL, Minn. (PRWEB) , ... May 22, 2017 , ... ... one young man’s experience learning to live with Bipolar 1. Donald Rodriguez takes readers ... icy mountain in Alaska in the dead of winter and to a dark place ...
(Date:5/21/2017)... , ... May 19, 2017 , ... Chris Cornell, 52, was found dead on the ... one of the most respected lead singers in the rock industry would take his own ... mental illness. FindaTopDoc investigates how mental illness played a role in the death of ...
(Date:5/21/2017)... ... May 21, 2017 , ... ... together a cross-disciplinary group of scholars, policymakers, and activists wanting to address equity ... Equity is the third book from a recent series of from this ...
(Date:5/19/2017)... Delaware (PRWEB) , ... May 19, 2017 , ... In ... home, PlushBeds , a luxury online mattress company that specializes in natural and ... (the nation’s leading grassroots autism organization) for every unique share their recent viral ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Hill Agencies, a family managed ... throughout the California Central Valley, is announcing a joint charity initiative with the Boys ... a local kid’s camp event. , The Boys and Girls Club of Kern County ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 10, 2017 Hologic, Inc. (Nasdaq: ... the fiscal second quarter ended April 1, 2017 . ... increased 666.7% compared to the prior year period as ... a significant gain, while non-GAAP diluted EPS of $0.50 ... 3.8% in constant currency terms.  Excluding the effects of ...
(Date:5/9/2017)... May 9, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, today announced it has earned a spot on ... list. The Company was ranked among 500 U.S. employers ... and Healthcare Equipment and Services. The annual ... an anonymous, independent survey of over 30,000 employees across ...
(Date:5/8/2017)... , May 8, 2017  Diplomat Pharmacy, Inc. ... Communications, Inc. ("WRB"), a health care service center ... WRB specializes in relationship management programs for ... WRB will join ... commercialization support services for manufacturers, biotech firms, and other ...
Breaking Medicine Technology: