Navigation Links
A Study Finds VENs Devastated in FTD

The official journal of the American Neurological Association, examined brain tissue acquired at autopsy and found that VENs were devastated in FTD//.

Von Economo neurons (VENs) are uniquely shaped brain cells that seem to have evolved in a select group of socially complex species: great apes, humans, and, as reported last month, whales. Across species, VENs are localized to frontal brain regions associated with cognition, emotion and social behavior. Frontotemporal dementia (FTD), a common neurodegenerative condition, is characterized by early breakdown in social and emotional awareness and is accompanied by atrophy and dysfunction in the brain areas where VENs are located. A new study published in the December 2006 issue of Annals of Neurology.

Led by William W. Seeley, M.D., of the Department of Neurology at the University of California, San Francisco, researchers quantified anterior cingulate cortex VENs in seven patients with FTD, five with Alzheimer’s disease (AD), and seven control subjects who were not demented. All FTD patients had prominent changes in social behavior and emotion, sometimes accompanied by deficits in cognitive function.

In contrast, AD patients had an array of cognitive symptoms, including memory and language impairment, with little change in social behavior. The researchers found early, severe, and selective loss of VENs in FTD, which showed a 69% reduction compared to AD and controls after controlling for overall neuronal loss.

"Our findings suggest that selective VEN loss is a defining feature of FTD but does not apply to AD," the researchers state, adding that future research should explore how VEN loss relates to specific social/behavioral deficits in FTD and other disorders where such deficits are a defining feature.

VENs receive chemical signals from dopamine, serotonin, and vasopressin systems that play important roles in social and emotional bonding. These functions are disrupt ed early in FTD but spared in AD, the authors note. While drugs aimed at preserving VEN function may help curtail FTD symptoms, basic studies of VEN biophysical and molecular properties are needed to clarify the mechanisms that cause VENs to degenerate in FTD.

"Distinctive functions of these unique cells may prove invaluable in health, yet may also expose us to specific forms of developmental or later-life illness," the authors conclude. "The link forged here between VENs and FTD should spawn further studies of how human brain evolution relates to human brain disease."

Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company ... of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every ... meet the highest standard. , These products are also: Gluten Free, Non-GMO, ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
(Date:9/12/2017)...  Consumer reviews on the independent review site Consumer Affairs ... company for hearing aids, ranking it higher than Miracle Ear ... ... For Hearing Aids ... online store that provides high performance, state-of-the-art, German-engineered hearing aids directly ...
Breaking Medicine Technology: