Navigation Links
A Stroke of Bad Luck for Vioxx

The anti-inflammatory drug Vioxx has been in the news for the wrong reasons and now scientists seem to have more clarity regarding Vioxx and the causative agent of the side-//effects. The answer hovers around the vital property of the drug - the blood clotting mechanism, British scientists reveal.

These drugs known as COX-2 inhibitors are most often used to alleviate pain in chronic conditions like arthritis. The drugs achieve its purpose by hampering the function of the COX-2 enzyme, present in the inflamed areas. The medications also halt the COX-1 enzyme, found in the lining of blood vessels.

In 2004, Vioxx was recalled from the market due to perceived health risks. Prof. Jane Mitchell from the National Heart and Lung Institute at Imperial College London and her colleagues are of the opinion that blocking the COX-1 enzyme may result in clotting of blood. And, if the drugs are consumed in regular doses, this could enhance the risk of stroke or heart attack.

'Our new research is exciting because it means we can work on developing better COX-2 inhibitors that don't pose the same risks in terms of heart attacks and strokes,' Mitchell said.

Researchers had all along believed that COX-2 inhibitors caused the blockage of the COX-2 enzyme in the endothelium, triggering the adverse reaction. This study has lent a valuable insight, which is the absence of COX-2 enzyme in the endothelium and the presence of COX-1 enzyme, which is the reason behind the adverse side-effect. Impediments to the COX-1 enzyme could result in clots, that may trigger the adverse reaction, scientists said.
SAV
'"/>




Page: 1

Related medicine news :

1. Amphetamines Help Recovery of Stroke Patients
2. Cough Syrup Ingredient Linked to Stroke
3. Estrogen Does Not Prevent Recurrent Strokes
4. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
5. Triglycerides Linked To Stroke Risk
6. Strokes increased during squatting
7. Drug Combinations May Boost Stroke Risk
8. Stroke and Dementia - a ghastly association
9. Stroke risk might be linked to antibody
10. Stroke Risk and Fish :A factual interconnection
11. Fewer teeth & Increased Ischemic Stroke risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... Tampa to offer patients with non-valvular atrial fibrillation (A-Fib) an alternative to long-term ... Since first offering the procedure in April of 2015, Florida Hospital Pepin Heart ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... use ultraviolet light A (UV-A) for photosynthesis, researchers Juntian Xu and Kunshan Gao ... brown seaweeds. The pair observed that when photosynthetically active radiation (i.e. the white ...
(Date:5/5/2016)... ... ... Derrin Doty Group has unveiled the latest charity campaign in their ongoing ... Seattle. The insurance provider’s caring team has been so moved by the sudden death ... from the flu, that they have decided to extend their original campaign. Compassionate community ...
(Date:5/5/2016)... ... 05, 2016 , ... The University of Western States (UWS) ... 2016 National SACA Leadership Conference on the Portland campus September 23-25. The conference ... come together and develop skills to be future leaders in the profession. ...
(Date:5/5/2016)... ... ... Vitenas Cosmetic Surgery has been named as one of the eight recipients ... and the Academy of Architecture for Health. The building, brainchild of founder Paul Vitenas, ... in October of 2014. , The prestigious Healthcare Design Awards are ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 ... addition of the  "Europe Thalassaemia Market and ... their offering.       (Logo: ... Europe Thalassaemia Market and Competitive Landscape Highlights ... pipeline products, Thalassaemia epidemiology, Thalassaemia market valuations ...
(Date:5/4/2016)... Holdings (NYSE: CODI ) ("CODI," "we," "our" ... businesses, announced today its consolidated operating results for the ... Quarter 2016 Highlights , Generated Cash Flow Available ... $13.6 million for the first quarter of 2016; ... first quarter of 2016; , Paid a first ...
(Date:5/4/2016)...  It,s time for an upgrade. There are many medical recorders on the market ... the illustrious DVMAXX HD  offers unparalleled connectivity and functionality.  Ampronix  is a renowned ... manufacturer of innovative technology.  Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
Breaking Medicine Technology: