Navigation Links
A Step Towards Unraveling The Schizophrenia And Depression Mystery

In what can be considered as an important breakthrough in our still limited understanding of major mental illness, researchers have identified a new gene linked to major mental illness // that links back to a previously discovered gene known to increase the risk of schizophrenia and depression.

Scientists from the Universities of Edinburgh and Glasgow, together with scientists from the pharmaceutical company Merck, Sharp & Dohme Limited, report the discovery of the second gene, phosphodiesterase 4B (PDE4B) in the Nov. 18 issue of the prestigious journal Science. Their discoveries could lead to the eventual development of new drugs to treat mental health problems.

In 2000, researchers at the University of Edinburgh identified a gene they called Disrupted in Schizophrenia 1 (DISC1), which was found to increase the chances of people developing schizophrenia, bipolar disorder (manic depression) and major clinical depression.

Now, new research by the two Universities and by scientists from the pharmaceutical company Merck Sharpe and Dohme reveals that damage to the gene PDE4B is also seen to increase the risk of developing mental illness.

PDE4B was already known to play an important role in how the brain thinks and builds memories, but had not previously been linked to mental disorder. In addition, researchers have discovered that DISC1 acts as a regulator for PDE4B, creating a 'pathway' between the two genes.

"It is now clear that the DISC1 gene plays an important role in the risk of developing schizophrenia or bipolar affective disorder. The new genetic link we have made to PDE4B and how that links back to DISC1 sheds much needed light on these debilitating disorders. It also suggests a new way of thinking about developing better and effective medicines."

According to Professor Miles Houslay of the University of Glasgow, "This new research has the potential for developing novel ways of diagnosing and treating this debilitating disease."

Peter Hutson, the Neuroscience Research Centre, Merck Sharp & Dohme, said: "Mental illness remains a scourge of society. Our insights into the important role that the proteins PDE4B and DISC1 may play in the mis-function of the brain that leads to schizophrenia will lead our thinking in the development of new treatments for this disorder"

The new discovery may in the future lead to the eventual development of new drugs to treat mental health problems, the researchers said.


'"/>




Related medicine news :

1. Looking Towards More Effective Leukemia Treatment
2. Attitude Towards AIDS Patients – Time For A Change
3. Scientists Awarded Appropriately For Contribution Towards Medical Research
4. Are Women Not Hearty Enough Towards Seeking Heart Care?
5. RPB grants $7.9 Million Towards Research
6. Blood Transfusion May Have Contributed Towards Hepatitis C
7. ViroPharma Shares Fall As FDA Moves Towards Generic Vancocin
8. Bird Flu Spreading Towards Madhya Pradesh
9. Madhya Pradesh Shows Indifferent Attitude Towards Infant Mortality
10. Mother’s Attitude Towards Immunisation Makes it Inaccessible to Childre
11. BreastScreen Australia Is Being Sued Towards Medical Negligence
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: