Navigation Links
A Protein in Brain Cells Controls Obesity: Research

receive those messages as they arrive, SH2B1’s partnership with JAK2 is an important one. In a previous paper, Rui and his former mentor and current colleague Christin Carter-Su, Ph.D., showed that SH2B1 encourages the action and production of JAK2, unlike two other proteins that have been shown by other teams to reduce its activity. Carter-Su is a professor of molecular and integrative physiology and heads the biomedical research division of the Michigan Diabetes Research and Training Center.

In addition to revealing the importance of SH2B1 activity in the brain, the new paper shows that SH2B1 is expressed in four different forms in many tissues of the body, including fat cells known as adipose tissue, as well as the liver, heart, pancreas and muscle.

Rui and his team also explored the role of SH2B1 in fat cells, finding that the knockout mice that lacked the SH2B1 gene stored away much more fat than normal mice, and had much larger fat cells – giving them two-and-a-half times more body fat content than normal mice. The mice that had some of their SH2B1 restored in just their brains by genetic alteration did not experience this – and in fact had less fat than normal mice.

Since these mice lacked the ability to make SH2B1 in their fat cells, the authors suspect that fat-cell SH2B1 encourages the storing of fat. When they tested this theory, they found that SH2B1 appeared to help mouse embryonic cells turn into fat cells, a process called adipogenesis. But, they suspect, the action of SH2B1 in the brain trumps its action in fat tissue, leading to the development of obesity in mice that lack SH2B1 in both locations.

Rui and his team now hope to explore SH2B1's role in the brain and body even further, and hope to translate their findings into clinical research involving humans. They hope that their findings will help lead to better tactics for understanding the causes of obesity and its consequences, including Type 2
'"/>




Page: 1 2 3 4

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein Brain Cells Controls Obesity Research

(Date:8/27/2014)... Washington, DC (PRWEB) August 27, 2014 ... Inc.’s Diplomat University were announced as the winners ... August issue of Atlantic Information Services, ... article penned by the company’s founder and Principal ... companies were commended for meeting the true definition ...
(Date:8/27/2014)... Top10BestSEOHosting.com compares many popular hosting suppliers and ... recommended suppliers for webmasters who want to buy ... GoDaddy provide stellar hosting products and services for ... to provide a wide range of advanced features ... that helps diminish the inherent complexity and learning ...
(Date:8/27/2014)... and Ontario, Canada (PRWEB) August 27, 2014 ... through a huge transformation as was revealed in a ... 2014 survey were not just surprising but astonishing as ... survey carried out online interviewed existing members on the ... Facebook. , According to Kaly, 10yeargap marketing department manager," ...
(Date:8/27/2014)... Discover Leadership Training is the foremost expert in ... comprehensive leadership programs. As the Vice President of Discover ... realm of outcome-focused and benefit-driven choices. Barb Moses is ... series titled, “A Women’s Guide to Making Her Life ... part webinar is titled, “My Current Story” which will ...
(Date:8/27/2014)... August 27, 2014 Overcoming a turbulent past ... found his niche. The Women’s Radio Network, WRNW1, has recently ... continued support and dedication to the WRNW1 family. KC states, ... have such a positive atmosphere.” After KC Armstrong publicly announced ... of the Howard Stern show, “Howard 100 News,” have decided ...
Breaking Medicine News(10 mins):Health News:Specialty Pharmacy Solutions Founder Reveals Winners of Innovation Competition in August Issue of AIS Newsletter 2Health News:Specialty Pharmacy Solutions Founder Reveals Winners of Innovation Competition in August Issue of AIS Newsletter 3Health News:Excellent Hosting Suppliers Recommended By Top10BestSEOHosting.com 2Health News:Survey Reveals Younger Women Dating Older Men 2Health News:Survey Reveals Younger Women Dating Older Men 3Health News:Barb Moses, Vice President of Discover Leadership Training, Announces New Webinar Titled, “A Women’s Guide to Making Her Life Story a Bestseller” 2Health News:The Women's Radio Network, WRNW1, Signs KC Armstrong to a Multi-Million Dollar Contract 2
... Group, Inc. (NYSE Amex: QGP ) ( ... Stock Transfer and Trust Company to act as Transfer Agent ... CEO, commented, "Continental Stock Transfer has been in business for ... as a comprehensive and customer-centric company that can facilitate the ...
... NETworks to get on the map. , ... Washington, ... a worldwide fundraiser challenge today to raise money to send lifesaving ... number one killer of refugees. Supporters are holding hundreds of fundraisers ...
... leading provider of strategic workforce management consulting and implementation services, ... to accommodate the firm,s growing base of healthcare clients striving to ... advanced workforce management solutions. , ... Denver, CO (PRWEB) ...
... holiday fast approaching, tons of chocolate will soon be consumed. Dr. Dave ... chocolate and which is healthier for you. , ... (PRWEB) March 31, ... Easter Bunnies are unleashed on the world; given as sweet treats for ...
... Helps Determine Benefits Included in a New Law and Manages Applicants, ... Company (NYSE: IBM ), today announced that ... Castilla y Leon region in Spain, will be helping its citizens ... through the use of a new system built around IBM ILOG ...
... N.C. A recent discovery by researchers at Wake Forest ... new drug that inhibits tumor growth in cancer patients and ... discovery stems from a study, recently published in the ... United States of America, in which researchers looked at angiogenesis ...
Cached Medicine News:Health News:The Quantum Group Announces Transition to Continental Stock Transfer 2Health News:The Quantum Group Announces Transition to Continental Stock Transfer 3Health News:Nothing But Nets Launches World Malaria Day Fundraising Challenge 2Health News:Nothing But Nets Launches World Malaria Day Fundraising Challenge 3Health News:Director of Healthcare Solutions Appointed to Guide Workforce Management Initiatives for Hospitals and Long Term Care Facilities 2Health News:Director of Healthcare Solutions Appointed to Guide Workforce Management Initiatives for Hospitals and Long Term Care Facilities 3Health News:Poison Dressed as an Easter Bunny 2Health News:Spain's Junta De Castilla y Leon Streamlines Benefits Delivery for Dependent Care With IBM ILOG JRules 2Health News:Blood protein may hold key to stopping tumor growth in cancer patients 2
(Date:8/26/2014)... 2014  Actavis plc (NYSE: ACT ), a ... Saunders , CEO and President of Actavis, will provide an ... Stanley Global Healthcare Conference 2014 in New York, ... The presentation will take place on Tuesday, September ... Hyatt New York, 109 East 42 nd Street, ...
(Date:8/26/2014)... Research and Markets  has announced the ... 2014-2018" report to their offering. Intranasal ... the administration of drugs for the treatment of local ... allergic and non-allergic rhinitis and sinusitis. The nose is ... vaccination and systematic drug delivery. Continuous ...
(Date:8/26/2014)... comes to diabetes supplies, innovations are often accused of ... answer a real medical need. Fitting ... shows how long it,s been since your last injection. ... insulin doses. Very easy to use, Timesulin starts automatically ... after an injection. There is no settings or complicated ...
Breaking Medicine Technology:Actavis to Present at Morgan Stanley Global Healthcare Conference 2014 2Global Intranasal Drug Delivery Market 2014-2018: Key Vendors are Becton, Dickinson and Company, GlaxoSmithKline, Johnson & Johnson and Novartis 2Global Intranasal Drug Delivery Market 2014-2018: Key Vendors are Becton, Dickinson and Company, GlaxoSmithKline, Johnson & Johnson and Novartis 3Montméd obtains reimbursement of Timesulin, the smart insulin pen timer cap, by major insurance companies in Canada 2
... The 1000 plate capacity MG-1000 ... workstations. Two people working side by ... in those labs that need it. ... colony counter inside for real-time growth ...
... is the most versatile orthopedic/trauma ... designed for both lower body ... an integrated shoulder attachment. The ... operating table for your most ...
... 1700 Series Outpatient Surgical Table is built ... Skytron's other specialty and general purpose surgical ... features such as 180-degree top rotation for ... side rails will accommodate a wide variety ...
... The schaerer axis ... been specially designed for ... maximum C-arm access. The ... possibilities and the offset ...
Medicine Products: