Navigation Links
A Protein In Brain Regulates Anxiety And The Consumption Of Alcohol

The researchers from the University of Illinois at Chicago (UIC), have reported in a study conducted on rats, the brain protein that maintains the nerve cells might also regulate anxiety and alcohol consumption. // Their study was published on the 9th August in the Journal of Neuroscience.

Reports have shown that previous studies by the UIC researchers had first recognized a gene that controls anxiety and alcohol consumption. Dr. Subhash Pandey, the professor of psychiatry and anatomy and cell biology at UIC and Jesse Brown VA medical centre and lead author of the paper, said, “We knew that gene, called CREB, controls the expression of a number of important genes in the brain.” In their new study, they further showed that a protein that was made by one of those CREB-controlled genes also affects the anxiety and the drinking behaviour depending on its level in two areas of the brain.

Pandey and his colleagues injected DNA of complementary sequence to the gene of the protein, called brain-derived neurotrophic factor (BDNF), into the brains of rats to block the gene from expressing BDNF. The "anti-sense" DNA was injected into three areas of the amygdala, an area of the brain associated with emotion and fear.

The researchers found that when levels of BDNF in the central and medial areas of the amygdala were lowered, anxiety and alcohol consumption increased. Decreased levels of BDNF in the third area, called the basolateral amygdala, had no effect.

When levels of BDNF in the central and medial amygdala were restored to normal by injecting BDNF, anxiety, and alcohol consumption diminished.

The researchers measured anxiety by observing the rat's exploratory behaviour in a maze. Alcohol consumption was measured by offering the animal’s one drinking bottle with water and one with alcohol, and noting the proportion of alcohol imbibed.

BDNF plays a vital role in the growth and maintenance of neurons. Man y human studies have suggested that variations in the BDNF gene may be associated with alcoholism and anxiety disorders, Pandey said.

“In people, alcoholism is very frequently associated with anxiety disorders," he said. “And it is well established that high levels of anxiety promote alcohol consumption and also play a crucial role in relapse to alcohol drinking.”

Pandey said the new research might suggest a target for drugs to treat or prevent anxiety and alcoholism.

"Our study suggests a molecular, neurochemical mechanism in the amygdala which may be responsible for the association of high levels of anxiety with excessive alcohol-drinking behaviour," he said.

Source: EurekAert
'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming ... set out for each of his children. “The Angel” is the creation of published ... in New York City, and impassioned writer. , When asked of her new book, ...
(Date:1/20/2017)... ... ... Forgive You”: a fine examination of how God handles sin, including how to let ... Stephen Miller, who, for over ten long years has been waiting to release this powerful ... Tobago, he has been serving the Lord for over twenty years, and he has been ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Christmas in ... creation of published author, Sara Seymour, who lives in Lafayette, Indiana where she works ... sips on iced coffees and writes. , Published by Christian Faith Publishing, Sara Seymour’s ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Knowledge is ... be guided by faith. “Knowledge is God’s Lighthouse” is the creation of published author, ... cookbooks, novels, and poetry collections. , “I have been writing since high school ...
(Date:1/20/2017)... ... January 20, 2017 , ... “God's Miracle Man: Against All Odds”: ... creation of published author, Keith C. A. Tucker, son of Minister Delores Pinnock and ... pastured by Reverend Mark Hardy , “While sitting up in bed, I felt a ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... The global immunomodulators market is expected ... to a new study by Grand View Research, ... driven by high R&D investments employed by the ... new and therapeutically advanced drugs. This is believed ... unprecedented rate into the immunomodulators market hence providing ...
(Date:1/19/2017)... , Jan. 19, 2017 Report Details ... ... Opportunities for Leading Companies – our new study reveals ... discusses issues and events affecting the Alzheimer,s disease therapeutics ... to answer these key questions: - How is the ...
(Date:1/19/2017)... 2017 According to a study conducted by ... to witness a CAGR of 6.5% during the forecast period 2016-2024. ... continue to be the leading market for cryotherapy globally during the ... Highlights ... ensuring affordable and adequate supply of gas in order to provide ...
Breaking Medicine Technology: