e solidly the vaccine’s impact on overall clinical course.
Dr. Elke Jaeger of Krankenhaus Nordwest in Frankfurt, Germany, the paper’s primary author, says this study is the first within the CVC to report on the effectiveness of recombinant viral-vector antigen delivery mechanisms. “Our results show this vaccination strategy is effective and requires further investigation.” Dr. Jaeger, a member of the Cancer Vaccine Collaborative, will share the details of her team’s findings with other CVC researchers at their annual meeting in New York City in early October.
In addition to reporting the specific study results, the authors of the PNAS paper also call for a reevaluation of the benchmarks of success currently applied to cancer vaccine studies.
“Many cancer immunologists would argue that the success criteria that have been applied to chemotherapeutic investigational new drugs, for instance, are not necessarily those by which immunotherapies should be judged,” Dr. Old says.
“Yes, the ultimate endpoint would be complete, long-lasting remission, as sometimes happens in these vaccine studies,” Dr. Old says. “However, such cases are at present few and far between. Rather, we are coming to realize and, more importantly, to accept that a more realistic benchmark of clinical success with immunotherapy is disease stabilization—that is, control of cancer’s growth.” According to Dr. Old, from what scientists currently understand about cancer immunosurveillance and immunoediting, vaccine-related stabilization of cancer would correspond to returning the body from a state of tumor escape to a state of tumor equilibrium.
“Disease stabilization as a successful clinical outcome makes sense when talking about immunotherapy,” Dr. O’Donnell-Tormey says, “especially at this early stage in the development of this new approach to treating cancer. We have a long way to go, and the Cancer Vaccine Collaborative is doing a lot to move Page: 1 2 3 4 Related medicine news :1
. Promising Treatment for Diabetes2
. Life after Bypass not so Promising for Women.3
. Promising cure for West Nile Virus
. Deadly Diarrhoea Vaccine – Trail Results Promising5
. Novartis MS Drug Shows Promising Results6
. Sunitinib a Promising Agent for Treatment of Renal Cell Cancer7
. Promising Care Model For Bipolar Disorder8
. Promising Brain Tumor Treatment In The Offing9
. Sea Creatures Toxin Could Lead to Promising Cancer Treatment10
. Vaccine Promising Against Hepatitis E11
. Groups Join Forces to Fund Promising Lung Cancer Research