Navigation Links
A Novel Technique Nudges Genes Into Activity

Researchers at UT Southwestern Medical Center have found a new technique that employs RNA, a tiny chemical cousin of DNA, to turn on genes could lead to therapeutics// for conditions in which nudging a gene awake would help alleviate disease. This gene-activating method provides researchers with a novel research tool to investigate the role that genes play in human health.

In a paper appearing online at Nature Chemical Biology and in an upcoming edition of the journal, lead author Dr. Bethany Janowski, assistant professor of pharmacology at UT Southwestern, and her colleagues describe how they activated certain genes in cultured cells using strands of RNA to perturb the delicately balanced mixture of proteins that surround chromosomal DNA, proteins that control whether genes are turned on or off.

Dr. David Corey, professor of pharmacology and the paper’s senior author, said the results are significant because they demonstrate the most effective and consistent method to date for coaxing genes into making the proteins that carry out all of life’s functions – a process formally called gene expression.

In any medical specialty, Dr. Janowski said, there are conditions where increased gene expression would prove beneficial.

"In some disease states, it’s not that gene expression is completely turned off, but rather, the levels of expression are lower than they should be," she said. As a result, there is an inadequate amount of a particular protein in the body. "If we can bring the level up a few notches, we might actually treat or cure the disease," Dr. Janowski said.

For example, some genes are natural tumor suppressors, and using this method to selectively activate those genes might help the body fend off cancer, Dr. Janowski said.

Genes are segments of DNA housed in chromosomes in the nucleus of every cell and they carry instructions for making proteins. Faulty or mutated genes lead to malfunctioning, missin
'"/>




Page: 1 2 3

Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel Technique Nudges Genes Into Activity

(Date:7/31/2014)... 2014 0-6 Pack Abs has finally been ... therapist expert Dr. James Vegher. Together they have launched ... relieve digestive issues, tone core muscles, improve posture, eliminate achy ... core exercises used to re-train the body in order to ... 0-6 Pack Abs review, Shane Michaels, a fitness ...
(Date:7/31/2014)... In today’s world, a good night’s sleep has become ... apnea (a medical problem where the airway collapses during sleep ... the rest they need to face their daily challenges. ... million people in the United States alone have sleep apnea. ... of those treated, many cannot tolerate their prescribed medical device ...
(Date:7/31/2014)... Vegas, NV (PRWEB) July 31, 2014 Hook Your ... way to get ex’s to feel emotionally hungry for their partner, ... a second chance. This little trick has been taught to ... , After a quick Hook Your Ex review , Shane ... who is suffering pain from a breakup a second chance at ...
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 ... incorporating Pioneer Millworks’ reclaimed wood to create a ... environment. Their newest location features reclaimed barn ... restaurant, with custom selected mixed softwoods flowing throughout ... crafted by Pioneer Millworks’ sister company New ...
(Date:7/31/2014)... US Hair Restoration Founder, Dr. Parsa Mohebi, has recently ... Mohebi Hair Restoration. Since first opening in 2008, US ... and around the world, who traveled to one of its ... patients achieved the full benefits of a variety of hair ... Dr. Mohebi. They have come to understand how his ...
Breaking Medicine News(10 mins):Health News:Zero To Six Pack Abs System Review Exposes Tyler Bramlett And Dr. James Veghers’ New Ab Training Program 2Health News:Zero To Six Pack Abs System Review Exposes Tyler Bramlett And Dr. James Veghers’ New Ab Training Program 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Hook Your Ex Review by Shane Michaels Exposes Steve Pratt And His New Method For Getting Back With The Ex 2Health News:Popular Tavern Restaurant Features Pioneer Millworks’ Reclaimed Wood in New Locations 2Health News:US Hair Restoration Becomes Parsa Mohebi Hair Restoration 2
... new technology called IMRT , , TUESDAY, Feb. 26 (HealthDay ... complex radiation treatment for killing tumors and sparing healthy ... to the next than previously thought, a new study ... and serious problem for the radiation oncology community because ...
... of drugs known as erythropoiesis-stimulating agents (ESAs) is associated with ... deep veins of the legs or in the lungs) and ... the February 27 issue of JAMA. , The ESAs erythropoietin ... with cancer. Some studies have indicated that there may be ...
... blood vessel growth worsens ovarian cancer, but its production can ... a fatty nanoparticle, a research team led by scientists at ... in the Journal of the National Cancer Institute. , "The ... cancer," said senior author Anil Sood, M.D., professor in the ...
... As global energy consumption rises, the ethical stakes of ... with it. , Experts from academia, business and the ... Knoxville, this April to discuss these issues and more. ... the Environment will be held April 10-12 at the ...
... an Insane ... Industry, BEVERLY HILLS, ... is asking the,question why the death of Heath Ledger is being treated ... is being treated with kid gloves, for instance,yet Britney Spears is afforded ...
... Design and Development Capabilities ... to Support Asian Market -, WARSAW, ... independent provider of products to the global orthopedic,device industry and other ... the next three years to expand its Malaysian,operations by increasing manufacturing ...
Cached Medicine News:Health News:Study Finds Variations in Doses of Radiation Therapy 2Health News:Study Finds Variations in Doses of Radiation Therapy 3Health News:Drugs used for cancer-associated anemia linked with increased risk of blood clots, death 2Health News:Researchers identify and shut down protein that fuels ovarian cancer 2Health News:Researchers identify and shut down protein that fuels ovarian cancer 3Health News:Symmetry Medical to Expand Malaysian Operations 2Health News:Symmetry Medical to Expand Malaysian Operations 3
(Date:7/31/2014)... Calif., July 31, 2014 Pharmacyclics, Inc. (the "Company") ... recent developments for the quarter ended June 30, 2014. ... June 30, 2014 Revenue Total revenue for the quarter ... million for the quarter ended June 30, 2013 primarily due ... million. Total revenue for the six months ...
(Date:7/31/2014)... 2014 Nektar Therapeutics (Nasdaq: NKTR ) ... June 30, 2014. Cash and investments in ... compared to $309.1 million at March 31, 2014."The second half ... we look forward to significant milestones for a number of ... Chief Executive Officer of Nektar. "The first of these is ...
(Date:7/31/2014)...   Auxilium Pharmaceuticals , Inc. (NASDAQ: ... announced that the Company will release results for the ... before the opening of the U.S. financial markets. The ... at 8:30 a.m. ET to discuss results and highlights ... to be used during the call will be available ...
Breaking Medicine Technology:Pharmacyclics Reports Second Quarter 2014 Results 2Pharmacyclics Reports Second Quarter 2014 Results 3Pharmacyclics Reports Second Quarter 2014 Results 4Pharmacyclics Reports Second Quarter 2014 Results 5Pharmacyclics Reports Second Quarter 2014 Results 6Pharmacyclics Reports Second Quarter 2014 Results 7Pharmacyclics Reports Second Quarter 2014 Results 8Pharmacyclics Reports Second Quarter 2014 Results 9Pharmacyclics Reports Second Quarter 2014 Results 10Pharmacyclics Reports Second Quarter 2014 Results 11Pharmacyclics Reports Second Quarter 2014 Results 12Pharmacyclics Reports Second Quarter 2014 Results 13Pharmacyclics Reports Second Quarter 2014 Results 14Pharmacyclics Reports Second Quarter 2014 Results 15Pharmacyclics Reports Second Quarter 2014 Results 16Pharmacyclics Reports Second Quarter 2014 Results 17Pharmacyclics Reports Second Quarter 2014 Results 18Pharmacyclics Reports Second Quarter 2014 Results 19Pharmacyclics Reports Second Quarter 2014 Results 20Pharmacyclics Reports Second Quarter 2014 Results 21Pharmacyclics Reports Second Quarter 2014 Results 22Pharmacyclics Reports Second Quarter 2014 Results 23Pharmacyclics Reports Second Quarter 2014 Results 24Pharmacyclics Reports Second Quarter 2014 Results 25Pharmacyclics Reports Second Quarter 2014 Results 26Pharmacyclics Reports Second Quarter 2014 Results 27Pharmacyclics Reports Second Quarter 2014 Results 28Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 2Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 3Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 4Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 5Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 6Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 7Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 8Nektar Therapeutics Reports Financial Results for the Second Quarter of 2014 9
... Corporation has announced the release of its next-generation slide scanners, ... of the original series, the NanoZoomer 2.0 converts a 20 ... a 1.9-gigapixel color image in as little as 1 minute ... on a computer monitor, shared across computer networks, used for ...
... , CRANBURY, N.J., Oct. 7 Cornerstone Pharmaceuticals, Inc., ... research scientist Robert A. Weinberg, Ph.D., a founding member ... Professor of Biology at MIT, has joined the company,s ... discoveries of the first human oncogene (the ras ...
Cached Medicine Technology:New 'Virtual Microscope' System from Hamamatsu Offers Faster Acquisition of High-Resolution Slide Scans 2Cornerstone Pharmaceuticals Adds Acclaimed Cancer Research Pioneer Robert A. Weinberg, Ph.D. to Its Scientific Advisory Board 2Cornerstone Pharmaceuticals Adds Acclaimed Cancer Research Pioneer Robert A. Weinberg, Ph.D. to Its Scientific Advisory Board 3
... used for endophotocoagulation indications, ... uncompromised laser treatment of ... handpieces are compatible with ... (532 nm), OcuLight infrared ...
... The AT555 utilizes a patented hands-free automatic ... staff to take an accurate IOP measurement ... the headrest to the left or right ... head against the comfortable headrest pad. The ...
The Perkins has been established for well over 20 years as a "world standard" for hand held applanation tonometers....
The new TOPCON 8800 Series of auto refractors and auto kerato-refractors satisfies the needs of today's demanding eyecare practice !...
Medicine Products: