Navigation Links
A Novel Target for Type-2 Diabetes Atk2

Researchers at the University of Pennsylvania School of Medicine have discovered a potential new target for treating type 2 diabetes The target is a protein, along with its molecular partner, that regulates fat metabolism.

Over the last 10 years, we have begun to understand the importance of fat metabolism in diabetes, notes lead author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases at Penn and an Investigator of the Howard Hughes Medical Institute.

Type 2 diabetics are at a higher risk for cardiovascular disease because they also have disorders in fat metabolism as a result of obesity and abnormal insulin action. Birnbaum is also the Associate Director of the Type 2 Diabetes Unit for Penns Institute for Diabetes, Obesity, and Metabolism.

When a person eats a meal, the pancreas usually responds by secreting insulin that signals the liver to stop making glucose and burning fat. When a type 2 diabetic eats a meal, insulin cannot stop the manufacture of glucose in the liver, but it can stop the burning of fat stores. This gives the diabetic person a double whammy: fatty acids accumulate from food and from the liver. Consequently, more fat is deposited in tissues and obesity worsens.

Until now there was no clear connection between insulin and the control of fat metabolism. This study shows that when insulin is present, as it is after a meal, the protein Akt2/PKB adds a phosphate group to its molecular partner PGC-1a. When this happens, PGC-1a cannot activate the genes needed for fat metabolism.

The findings suggest that if a drug could induce Akt2/PKB to add the phosphate group (phosphorylation) to PGC-1a, then the liver of a diabetic might be fooled into stopping the oxidation of fat stores. Muscle and fat tissue also burn fat stores, and we are currently investigating whether PGC-1a and Akt2/PKB have the same role in those tissues, says Birnbaum.


'"/>




Page: 1 2

Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel Target for Type Diabetes Atk2

(Date:7/29/2014)... New high priced hepatitis C drugs will ... projected $2.9 to $5.8 billion next year, according to ... today by the Pharmaceutical Care Management Association (PCMA). Milliman ... as much as 8.6 percent in 2015 as a ... Olysio. , The study finds that the majority of ...
(Date:7/29/2014)... Alto, CA (PRWEB) July 29, 2014 ... and well-being in older adults. Once again, the non-profit agency ... Celebration, a free event for seniors. , This event gives ... active and maintain better health. There will be a variety ... and dancing, wellness vendors, tech demonstrations and artists. In addition, ...
(Date:7/29/2014)... kidney transplants receive steady follow-up care, the living ... make follow-up care more accessible, UC San Francisco ... to launch the first program in the country ... to living kidney donors. , UCSF will provide ... than 4,500 Walgreens pharmacies and Healthcare Clinic at ...
(Date:7/29/2014)... Bret Busacker , a partner in ... appointed to the Board of Directors for the American ... experienced business attorney with a focus on employee benefits ... wide spectrum of topics regarding equity and incentive compensation, ... His clients include public and private businesses, governmental entities, ...
(Date:7/29/2014)... Georgia (PRWEB) July 29, 2014 Just ... expanding offices to 4 new states, the exciting FX ... Special FX and one time farmboy from Arkansas, is ... of bringing innovative event technologies to the masses. ... the event packed island of Jamaica. This new ...
Breaking Medicine News(10 mins):Health News:New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2Health News:Avenidas Hosts Third Annual Successful Aging Celebration 2Health News:Caring for donors 2Health News:Caring for donors 3Health News:Holland & Hart Partner Brett Busacker Appointed to Board of Directors for American Red Cross of Greater Idaho 2Health News:Atlanta Special FX Rapidly Expanding Just Opens First International Corporate Office in Jamaica 2
... ... seek pain-relief that doesn,t come in traditional drug-form. With the launch of Oram Plus, developer ... ... has done it again with the development of his new gum disease treatment, Oram Plus., ...
... , ... ... ... ...
... Phoenix magazine, the ... 44-year history in April, both in terms of page count and magazine advertising sales revenue. ... ... economic climate where newspapers and magazines are struggling, Phoenix magazine is setting an ...
... , ... ... ... ...
... An asthma program specifically tailored to teens could help ... fatal complications, Medical College of Georgia researchers say. Black ... times greater than their white counterparts, and Dr. Dennis Ownby, ... and Immunology, believes asthma rates are as bad in rural ...
... ... recorded over a unique Celtic themed musical soundscape. , ... (PRWEB) March 9, 2010 -- Welsh Tree LLC ... ,Celtic Pathways by Jason Evans, in time for Saint Patrick,s Day, Wednesday March 17th. ...
Cached Medicine News:Health News:Oram Plus Set to Take the Pain out of Gum Disease and Cavities, Naturally 2Health News:The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide 2Health News:The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide 3Health News:The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide 4Health News:The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide 5Health News:The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide 6Health News:Phoenix Magazine Sets Magazine Advertising Sales Record With Best Doctors Issue 2Health News:Soft? Firm? When Choosing a Mattress, One Firmness Does Not Fit All 2Health News:Soft? Firm? When Choosing a Mattress, One Firmness Does Not Fit All 3Health News:Soft? Firm? When Choosing a Mattress, One Firmness Does Not Fit All 4Health News:Program could help teens control asthma 2Health News:Welsh Tree LLC Proudly Presents the Release of the Celtic Pathways CD by Jason Evans, in Time for Saint Patrick's Day 2Health News:Welsh Tree LLC Proudly Presents the Release of the Celtic Pathways CD by Jason Evans, in Time for Saint Patrick's Day 3
(Date:7/29/2014)... 29, 2014 Research and Markets ... Devices Market 2014-2018" report to their offering. ... respiratory device is a medical device used to provide ... in breathing and cannot achieve adequate oxygen levels to ... fibrosis, asthma, COPD, and ARDS require the need of ...
(Date:7/29/2014)... MOUNTAIN VIEW, Calif. , July 29, 2014 ... personal emergency response systems (PERS) market, Frost & ... Frost & Sullivan Award for Price Performance Value ... mobile usage directly captures expectations for tech progression ... of US consumers for these solutions. ...
(Date:7/29/2014)... CITY , July 29, 2014  The ... Grand American Hotel in Salt Lake City ... representing some of most respected healthcare organizations in the ... Catalyst , is an industry conference devoted to providing ... analytics,  an essential element of both accountable care initiatives ...
Breaking Medicine Technology:Global Respiratory Devices Market 2014-2018 2Frost & Sullivan Applauds MobileHelp for its Targeted Supplies for the PERS Market 2Frost & Sullivan Applauds MobileHelp for its Targeted Supplies for the PERS Market 3Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 2Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 3Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 4Health Catalyst Adds Keynote Speakers, New Sessions, and Expands Attendee Limit for Healthcare Analytics Summit 2014 5
... July 12 For two weeks beginning July 12 , ecoSTORE USA ... $1 off in-store coupon at 200 select Duane Reade drug stores in ... about why making No Nasty Ch e mic ... important. , , , ...
... GUANGZHOU, China , July 9 /PRNewswire-Asia/ -- ... "the Company"), a leading,manufacturer, developer and distributor of Western ... that its board of directors authorized a stock repurchase ... stock up to a value,of $2.0 million . ...
Cached Medicine Technology:Ecovisors to Advise Duane Reade Shoppers 2Ecovisors to Advise Duane Reade Shoppers 3China Medicine Announces Stock Repurchase Plan 2China Medicine Announces Stock Repurchase Plan 3
Shandon Paraffin Block Cartons...
... A histological embedment block ... This file system incorporates ... embedment block protection, simplified ... error and facilitation of ...
The Modular Storage Drawers provide permanent storage and identification of up to 165 embedding rings or 250 cassettes per drawer....
... The first instrumentation ... efficiently manage the ... Proven technology automatically ... collates cassettes sequentially. ...
Medicine Products: