Navigation Links
A Novel System For Clinical Banking Of Umbilical Cord Blood

Researchers from Italy have designed a closed circuit, where Umbilical cord blood (UCB) collection and RBC depletion are performed, in order to reduce the contamination risk and to speed the nucleated cell separation//.

Their findings appear in the journal Blood Cells, Molecules, and Diseases (available online 19 August 2005) Umbilical cord blood is a source of hematopoietic progenitor cells and is used as an alternative to the bone marrow or peripheral blood for treatment of several onco-hematological diseases.

Because of the limited number of CD34+ hematopoietic stem cells present in UCB units and of the elevated costs of cryopreservation, it is of paramount importance to select the UCB units that are clinically useful before storage and optimize banking efficiency by designing reliable procedures to process and freeze the selected units.

Nucleated cell (NC) and CD34+ cell content provides useful criteria to select UCB units since clinical data documented that the infused cell load (both NC and CD34+ cells) plays an important role in the successful outcome of transplants. By evaluating volume, CD34+ cell content, NC total amount, and NC density of 117 UCB units, the researchers found a significant association between CD34+ cell content and NC density and total amount, indicating these parameters as useful to decide UCB clinical utility.

Furthermore, the author set up a fast procedure to process UCB units for storage. A system for NC separation and volume reduction of UCB samples in a dedicated, germ-free, closed circuit was developed, where plasma and red blood cells (RBC) depletion was obtained by sedimentation in the presence of a 3.5% Polygeline solution. The separation by the closed circuit, where RBC depletion is obtained by Polygeline sedimentation, proved to be faster and provided a higher recovery of stem cells.

Since Polygeline has been clinically used as a plasma expander and no toxic effects on patients were reported, the protocol can be applied in the large-scale banking of UCB.
'"/>




Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... Colorado (PRWEB) , ... February 11, 2016 , ... Colorado ... Review as one of 334 spine surgeons to know in 2016 . The ... in the field of spine surgery. , Dr. Corenman understands the importance of ...
(Date:2/11/2016)... ... February 11, 2016 , ... Talix today announced ... , will be presenting at the 2016 HIMSS Annual Conference & Exhibition, taking ... During his session, “ Coding for Care: Using Data Analytics for Risk Adjustment ...
(Date:2/11/2016)... Rock, AR (PRWEB) , ... February 11, 2016 , ... ... in their community by announcing a new fundraiser in support of a local boy ... also hopes the campaign will bring awareness to, and rally support for, all local ...
(Date:2/11/2016)... ... February 11, 2016 , ... Pixel Film Studios brings the spirit of the ... the Christmas edition of the ProDrop series. Pick and choose from 30 unique designs ... spirit of Christmas using ProDrop's wintry generators. ProDrop Christmas is a Final Cut Pro ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... exhibiting at the American Academy of Dermatology Annual Meeting at the Walter E. ... is to raise awareness for both the condition of hyperhidrosis (excessive sweating) and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 Jeffrey Zucker , ... Trials, will present at this year,s Summit for Clinical Operations ... in Miami, FL. Zucker will discuss ... study execution, supporting SCOPE,s "Improving Site Study Activation and Performance" ... Thursday, Feb. 25 at 11:05 a.m. --> ...
(Date:2/11/2016)... , Feb. 11, 2016  Delcath Systems, Inc. ... medical device company focused on oncology with an ... liver cancers, announces the engagement of Lars ... Global Medical Consultant. Dr. Birgerson will provide strategic ... clinical operations team to help ensure timely facilitation ...
(Date:2/11/2016)... REDWOOD CITY, Calif. , Feb. 11, 2016 /PRNewswire/ ... that a podium presentation will be made at the ... Burn and Wound Care Symposium, which is being ... . This international conference covers the latest advancements in ... endorsed by the American Burn Association, Australian-New Zealand Burns ...
Breaking Medicine Technology: