Navigation Links
A Novel Method Of Detection Of High Nuclear Grade Localized Renal Cell Carcinoma

Elective nephron-sparing surgery (NSS) is considered appropriate for small renal cell carcinoma (RCC) tumors; however, it is still difficult to detect high nuclear grade RCC preoperatively. //

Although no specific tumor markers have been identified for RCC, immunosuppressive acidic protein (IAP) is a variable predictor of lymph node and distant metastasis in patients with RCC. At present it is impossible to determine the nuclear grade of RCC without removing the kidney.

Researchers from the Department of Urology, Nihon University School of Medicine, Tokyo, Japan evaluated clinicopathologic factors in an effort to identify a potentially useful preoperative predictor of high nuclear grade RCC.

The investigation, published in the October issue of the journal Urology consisted of 181 patients with histologically confirmed clear cell RCC. The positive predictive value, sensitivity, and specificity for detecting nuclear grade RCC were calculated individually for the largest tumor diameter. Hemoglobin, alkaline phosphatase, C-reactive protein (CRP), ferritin, and IAP levels were also determined in all patients preoperatively. Results obtained showed that a higher than normal C-reactive protein and IAP was associated with a 252% and 405% increase in the odds of a high nuclear grade, respectively. In the Stage T1 cases, elevated IAP was also associated with a 989% increase in the odds of a high nuclear grade.

AP level may thus be a useful predictor for detecting high nuclear grade localized RCC preoperatively. The results of this study demonstrated the effectiveness of CRP and IAP measurement as a means to detect high nuclear grade RCC preoperatively.

Although this study included only a small number of cases, the authors believe that the measurement of these acute-phase reactants alone or in combination with other acute-phase reactants can be readily extended to clinical situations in which the maximal tumor diameter and ot her important assessments indicate a need for accurate detection of high nuclear grade RCC preoperatively.

Related medicine news :

2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:

(Date:10/12/2015)... Grove Village, IL, USA (PRWEB) , ... October ... ... solutions and high-fidelity personal audio products, will present the latest version of Companion ... insert earphones for audiometry, at the European Union of Hearing Aid Acousticians’ (EUHA) ...
(Date:10/12/2015)... ... October 12, 2015 , ... FEI Behavioral Health, ... from EAP to crisis management, will present a session at the Wisconsin Society ... 14-16, 2015. , FEI’s Chief Operating Officer Daniel Potterton will present an informative ...
(Date:10/12/2015)... FL (PRWEB) , ... October 12, 2015 , ... ... Awareness Month, IQ Formulations today announced its charitable donation to the National Breast ... inspiring hope in those affected by breast cancer through early detection, education, and ...
(Date:10/12/2015)... ... October 12, 2015 , ... SQM Group is proud ... contact channel benchmarking study. Be a part of this insightful and leading-edge ... customer experience, customer journey, contact channel execution and intelligence, workforce optimization, and tools ...
(Date:10/12/2015)... ... October 12, 2015 , ... Holcomb – Kreithen Plastic ... in Florida, announced today that it will host “Plastic Surgery University,” an educational series ... Town Center (“UTC Mall”) in Sarasota, FL on Saturday, October 24, 2015. , ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Leadership of the National Association of Vision Care ... Aspasia Shappet , CEO of MESVision resumed her role as ... at its annual strategic planning meeting in Chicago ... the organization from May 2013 to May of this year. ... a result of the increased demands of his recent appointment ...
(Date:10/12/2015)... , Oct. 12, 2015 A new computer ... children can predict whether they will develop effective language ... to a study in the journal Brain and ... --> In the journal,s Oct. 12 online edition, ... computer program determines how specific regions of the brain ...
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
Breaking Medicine Technology: