Navigation Links
A Novel Method Of Detection Of High Nuclear Grade Localized Renal Cell Carcinoma

Elective nephron-sparing surgery (NSS) is considered appropriate for small renal cell carcinoma (RCC) tumors; however, it is still difficult to detect high nuclear grade RCC preoperatively. //

Although no specific tumor markers have been identified for RCC, immunosuppressive acidic protein (IAP) is a variable predictor of lymph node and distant metastasis in patients with RCC. At present it is impossible to determine the nuclear grade of RCC without removing the kidney.

Researchers from the Department of Urology, Nihon University School of Medicine, Tokyo, Japan evaluated clinicopathologic factors in an effort to identify a potentially useful preoperative predictor of high nuclear grade RCC.

The investigation, published in the October issue of the journal Urology consisted of 181 patients with histologically confirmed clear cell RCC. The positive predictive value, sensitivity, and specificity for detecting nuclear grade RCC were calculated individually for the largest tumor diameter. Hemoglobin, alkaline phosphatase, C-reactive protein (CRP), ferritin, and IAP levels were also determined in all patients preoperatively. Results obtained showed that a higher than normal C-reactive protein and IAP was associated with a 252% and 405% increase in the odds of a high nuclear grade, respectively. In the Stage T1 cases, elevated IAP was also associated with a 989% increase in the odds of a high nuclear grade.

AP level may thus be a useful predictor for detecting high nuclear grade localized RCC preoperatively. The results of this study demonstrated the effectiveness of CRP and IAP measurement as a means to detect high nuclear grade RCC preoperatively.

Although this study included only a small number of cases, the authors believe that the measurement of these acute-phase reactants alone or in combination with other acute-phase reactants can be readily extended to clinical situations in which the maximal tumor diameter and ot her important assessments indicate a need for accurate detection of high nuclear grade RCC preoperatively.

Related medicine news :

2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:

(Date:11/26/2015)... Bangalore, Karnataka (PRWEB) , ... ... ... an innovative online platform for mental health and wellness consultation, has collaborated ... self-empowerment, to holistically address their reader’s queries on topics on mental and ...
(Date:11/25/2015)... Indianapolis, IN (PRWEB) , ... November 25, 2015 ... ... clean water accessible for all, Water For Empowerment ™ attracts volunteers together ... on clean water by empowering women as key stakeholders in the process. The ...
(Date:11/25/2015)... Neb. (PRWEB) , ... November 25, 2015 , ... ... staffing companies, has been recognized once again for its stellar workplace culture with ... to Work.” , Medical Solutions’ Cincinnati office was named a finalist ...
(Date:11/25/2015)... ... , ... Ministers, senior government and UN agencies, representatives from ... Excellence, and public R&D institutions, civil societies and other partners gathered today at ... Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders Meeting. The three- day meeting ...
(Date:11/25/2015)... Angeles, CA (PRWEB) , ... November 25, 2015 , ... ... da Vinci surgical robot is being more and more widely heralded as a breakthrough ... assisted da Vinci method has over traditional laparoscopic surgery is that it can greatly ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 --> ... potential att använda SyMRI för att hitta ... patienter med multipel skleros (MS) eller hjärntumörmetastaser ... AB för att kunna använda SyMRI Research ... SyMRI kan man generera flera konstrastbilder från ...
(Date:11/26/2015)... November 26, 2015 ... adds "Global Repaglinide Industry ... Report on China Repaglinide Market, 2010-2019" ... data and information to its online ... . --> ...
(Date:11/26/2015)... 2015 ) ... "Radioimmunoassay Market by Type (Reagents & Kits, ... Clinical Diagnostic Labs), Application (Research, Clinical Diagnostics), ... report to their offering. --> ... of the "Radioimmunoassay Market by Type ...
Breaking Medicine Technology: