Navigation Links
A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues

In normal subcutaneous tissue, the interstitial fluid pressure (IFP) is negative, and so, when the subcutaneous tissue of an animal is exposed, fluid does not seep out. //By contrast, IFP is often increased in tumor tissue and forms a barrier against efficient drug delivery into the tumor.

Many anticancer drugs and antibodies used for treating patients with cancer are transported from the circulatory system through the interstitial space by convection (i.e. by streaming of a flowing fluid) rather than by diffusion. Increased tumor IFP causes inefficient uptake of therapeutic agents by decreasing convection. Cancer cells are therefore exposed to a lower effective concentration of therapeutic agents than normal cells, reducing treatment efficiency. Decreasing tumor IFP can thus improve drug delivery into the tumor.

There are several techniques described for IFP measurements, however, all of these require experience to use ramified instrumentation and surgical procedures. Drs Ugur Ozerdem, and Alan R. Hargens, from the La Jolla Institute for Molecular Medicine, and the University of California San Diego, USA, have recently developed a simplified procedure using a transducer-tipped catheter and a precision glide needle that allows reliable measurement of IFP in tumor tissues.

This novel procedure, using a polyurethane transducer-tipped catheter (Millar), allows reliable measurement of interstitial fluid pressure (IFP) in cancer tissues. Before and after each use, the transducer is calibrated at 37°C by a water column. After calibration, the transducer is passed through the lumen of a surgical needle. The sensor is kept in the lumen of the needle during penetration into the tumor. The sensor tip is then introduced into the center core of the tumor as the needle sleeve is withdrawn from the tumor surface.

This new technique, described in Microvascular Research (available online 31 August 2005), is simple and provides IFPs equal to those provided by the well-established, wick-in-needle technique. Using this new technique, the authors compared IFP in skin melanoma grafts in NG2 knockout and wild-type mice. Knocking out NG2 proteoglycan on vasculogenic and angiogenic pericytes was found to reduce interstitial fluid pressure in melanoma. This study also demonstrates that IFP is elevated in skin melanoma.

The simplified IFP measurement procedure described in this report will allow the basic researchers and clinicians to apply IFP measurement easily and widely as a useful tool in their research.
'"/>




Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel biopsy technique for prostate cancer
3. Novel computer model for breast cancer
4. Novel research on liver cancer
5. Novel way to fight cancer
6. Novel test for bowel cancer
7. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
8. Novel Therapy for Chronic Problem
9. Blood Sugar Kept In Control By Novel Protein
10. Novel antibiotic dressing developed for improved wound healing
11. United Kingdom Is Lagging In Novelty In The Field Of Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... ... ... Shark Finds and Kevin Harrington, and the Product Managers of AsSeenOnTV.pro are pleased to ... patented product that has solved some of the basic problems golfers have faced since the ... right after a rain shower, might understand the struggle of placing the club down for ...
(Date:2/8/2016)... ... February 08, 2016 , ... Brenntag Specialties, ... the Food & Beverage and Dietary Supplement market segments ... Canada and USA geographies east of the Rocky Mountains since 2012. Consistent ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... A man who has struggled to quit ... Freedom Laser Therapy , was determined to find solutions to his problems – and he ... Inventors Digest is ready to introduce his breakthrough inventions to the world and better ...
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates Insurance ... new community enrichment program, has teamed up with Citizens Opposed to Domestic Abuse in ... intimate abuse. To support all those victimized by the fear of violence in their ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... networking and relationship-marketing firm, announced today that nominations will be accepted February ... (ISE®) West Awards. , Awards include the Information Security Executive® of ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  Echo Therapeutics, ... device company focused on non-invasive continuous glucose ... today announced that it will host a ... 17, 2015 at 9:00 a.m. Eastern Time ... its corporate strategy, advancements in its CGM ...
(Date:2/8/2016)... , Feb. 8, 2016 ... the "Global Skin Protective Equipment Market 2016-2020" ... --> http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced the addition ... 2016-2020" report to their offering. ... ) has announced the addition of the ...
(Date:2/8/2016)... , Feb. 8, 2016   HighPoint ... November Research Group (NRG),s pharmacovigilance technology services division.  ... consulting services and an Oracle Argus Specialized partner, ... to Life Sciences companies. --> ... expands HighPoint,s life sciences capabilities and provides a ...
Breaking Medicine Technology: