Navigation Links
A Newly Identified Immunosuppressive Protein in Rheumatoid Arthritis

A complex autoimmune disease, rheumatoid arthritis (RA) is characterized by chronic inflammation and progressive joint damage. This process begins with hyperplasia//, or excessive increase in size and thickness, of synovial tissue. Along with provoking cartilage and bone destruction, this abnormal tissue growth is resistant to apoptosis, the natural cell death vital to the generation of healthy new cells.

Decoy receptor 3 (DcR3) is a newly identified member of the tumor necrosis factor receptor (TNFR) superfamily. A soluble protein, it is overexpressed in tumor cells, including lung and colon cancers, gastrointestinal tract tumors, and leukemia. It is also expressed in a variety of normal tissue—the colon, lung, stomach, spleen, lymph node, pancreas, and spinal cord. Because rheumatoid synovial cells share traits with tumor cells—both are resistant to apoptosis, both proliferate aggressively— DcR3 might play a role in the destructive course of RA. To investigate this possibility, researchers at Kobe University School of Medicine in Japan conducted the first study of DcR3 expression in RA fibroblast-like synoviocytes (FSL)—cells in the synovial membrane instrumental to the production of cartilage as well as synovial fluid. Featured in the April 2007 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), their findings expose DcR3 as one of the factors culpable for RA's hallmark hyperplasia and its crippling consequences.

For their novel study of DcR3, the researchers isolated and cultured FLS from 19 patients with RA, obtained during total knee replacement surgery. For comparison, FLS was also extracted in a similar manner from 14 patients with osteoarthritis (OA). For all samples, expression of DcR3 in FLS was measured by reverse-transcriptase-polymerase chain reaction and Western blotting. Then, apoptosis was induced by Fas, a protein ligand and member of the tumor necrosis factor (TNF) family. Finally, FLS we
'"/>




Page: 1 2

Related medicine news :

1. Obesity The Major Cause Of The Increase In Newly Diagnosed Diabetes
2. Newly Identified Strains Of Chlamydia Trachomatis – A Gateway To New Disease
3. Newly Cloned Wheat Gene May Boosts Foods Nutrient Contents – Says A Researc
4. Newly Discovered Immune Defense May Be Impaired In CF Airways
5. Differences Between BP Medicines and Newly-Diagnosed Diabetes Identified
6. Moratorium Proposed on Advertisements of Newly Approved Drugs
7. Potential New Cancer Gene Identified
8. Alcohol Dependence Gene Identified
9. More Causes of Bladder Cancer Identified
10. Dyslexia Gene Identified and Called "KIAA0319"
11. New Enzyme Identified For Arthritis
Post Your Comments:
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the business is ... company announces big discounts on its bamboo mats , ... is the world’s leader in bamboo flooring. According to ... 20, 2015. , The bamboo mats are made from ... All the bamboo strips for the mats are boiled ...
(Date:12/25/2014)... When head lice hits a home or school, parents ... rid of it while keeping it from taking over the ... the solution right in their neighborhood: Lice Troopers . ... full spectrum head lice screening and treatment services to families ... Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , ...
(Date:12/25/2014)... Dennis Thompson HealthDay ... Very sick children with complex chronic illnesses can receive effective, ... "medical home," with easy access to a team of dedicated ... less likely to become seriously ill and need either hospitalization ... treatment at an enhanced medical home clinic at the University ...
(Date:12/25/2014)... (HealthDay News) -- Overeating is common during the holidays, but ... an expert says. "Don,t arrive at a party hungry. ... know you,ll be attending a party, but deprivation leads to ... at Northern Westchester Hospital in Mount Kisco, N.Y., said in ... during the day and even to have a snack before ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... on a "fountain of youth" drug that can delay the ... a new study suggests. Seniors received a significant boost ... a genetic signaling pathway linked to aging and immune function, ... The experimental medication, a version of the drug rapamycin, improved ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3
... monoclonal antibodies effective against bird and seasonal flu ... working with researchers at the Dana-Farber Cancer Institute ... reported the identification of human monoclonal antibodies that ... including avian influenza A (H5N1) virus, previous pandemic ...
... the Jobseekers Facelift Giveaway ContestSAN FRANCISCO, May 12 ... Kim has established a Jobseekers Facelift Giveaway Contest. ... jobs, older applicants (those over 40) see facial surgery ... with younger applicants. "Of course, one,s accomplishments should set ...
... a leading innovator of noninvasive physiological monitoring solutions, ... oximeter, announced today the release of its personal ... The all-new GO2 provides patients a proven, cost-effective, ... oxygen saturation to complement their clinician-advised oxygen therapy ...
... those needing to work from home or on ... Ericom Software, a global leader in Application Access ... access solution, PowerTerm WebConnect can significantly reduce the ... during disaster situations, such as an H1N1 pandemic ...
... research grants to help solve some of the biggest ... the Engineering and Physical Sciences Research Council (EPSRC) , ... and treating major public health issues such as cancer, ... grants, worth 16.5m, have been given by the EPSRC, ...
... Bleak, NCPA Says It,s Much Worse DALLAS, May 12 ... today - will likely paint an extremely bleak future ... of trillions of dollars. As bad as those projections ... according to NCPA experts. "The reality is that Medicare ...
Cached Medicine News:Health News:Recent developments at Burnham Institute for Medical Research, May 2009 2Health News:Recent developments at Burnham Institute for Medical Research, May 2009 3Health News:Recent developments at Burnham Institute for Medical Research, May 2009 4Health News:Recent developments at Burnham Institute for Medical Research, May 2009 5Health News:Want to Help Your Job Hunt? Win a Facelift! 2Health News:Nonin Medical's GO2(TM) Personal Fingertip Pulse Oximeter Empowers Patients Worldwide 2Health News:Ericom's Remote Access and Business Continuity Solution Increases Immunity to Productivity Losses -- Combats Swine Flu Scare 2Health News:Ericom's Remote Access and Business Continuity Solution Increases Immunity to Productivity Losses -- Combats Swine Flu Scare 3Health News:$24.4 million for research into future health care solutions 2
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)...   TRU-D SmartUVC LLC, producers of the ... today that the General Services Administration has awarded the ... This newly formed agreement will allow TRU-D ... purchasers, including Department of Veteran Affairs and Department of ... purchasing solutions for the Ebola effort in ...
(Date:12/22/2014)... , Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... the treatment and management of epilepsy, today announced it will ... Conference on Wednesday, January 14, 2015, in San ... President and Chief Executive Officer, will speak at 11:00 AM ... be accessed by clicking on the Investor Relations link on ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... April 27 SI-BONE, Inc. ( Cupertino, California ), ... minimally invasive surgical (MIS) device to treat the sacroiliac (SI) joint ... at upcoming 2010 minimally invasive spine surgery meetings. , ... SI-BONE has been working with ...
... CareFusion Corporation (NYSE: CFN ) today announced plans to release third ... close of trading on the New York Stock Exchange. , ... The company will host a webcast and conference call on May 6 ... to discuss the results for its third quarter, ended on March 31, 2010 ...
Cached Medicine Technology:iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 2iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 3iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 4CareFusion Will Host an Earnings Conference Call on May 6 to Discuss the Results for the Third Quarter of Fiscal 2010 2
Designed for simple operation, the Model 515C pulse oximeter is ideal for use in any clinical setting; from emergency hospital transport to continuous monitoring in Anesthesia, Intensive Care and Gen...
... Models 512 and 513 handheld pulse ... advanced technology is able to process ... and speeds of 100 times per ... improved pulse oximeter performance during motion ...
The new Nellcor N-45 Handheld Pulse Oximeter is compatible with our complete line of OxiMax Pulse Oximetry Sensors, so clinicians have the convenience of Nellcors most advanced sensor technology in a...
... Pulse Oximeters are high performance, easy-to-use ... proven signal processing to track even ... with Oxismart Advanced Signal Processing and ... identify electronic and optical noise, as ...
Medicine Products: